3EQY

Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Mdm4 protein	polymer	85	9575.3	2	UniProt (O15151)	Homo sapiens	p53-binding protein Mdm4, Mdm2-like p53-binding protein, Protein Mdmx, Double minute 4 protein
2	C, D (C, D)	12-mer peptide inhibitor	polymer	12	1427.6	2
3	E, H (A, B)	GUANIDINE	non-polymer		59.1	2	Chemie (GAI)
4	F, G, I, J (A, B)	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
5	K, L, M, N (A, B, C, D)	water	water		18.0	260	Chemie (HOH)

Sequence modifications

A, B: 24 - 108 (UniProt: O15151)

PDB	External Database	Details
Ala 68	Gln 68	engineered mutation
Ala 69	Gln 69	engineered mutation
Ala 70	Glu 70	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	22005.7
Non-Polymers*	Number of molecules	6
	Total formula weight	498.0
All*	Total formula weight	22503.7

*Water molecules are not included.