3EQY
Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Mdm4 protein | polymer | 85 | 9575.3 | 2 | UniProt (O15151) In PDB | Homo sapiens | p53-binding protein Mdm4, Mdm2-like p53-binding protein, Protein Mdmx, Double minute 4 protein |
2 | C, D | 12-mer peptide inhibitor | polymer | 12 | 1427.6 | 2 | |||
3 | A, B | GUANIDINE | non-polymer | 59.1 | 2 | Chemie (GAI) | |||
4 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
5 | water | water | 18.0 | 260 | Chemie (HOH) |
Sequence modifications
A, B: 24 - 108 (UniProt: O15151)
PDB | External Database | Details |
---|---|---|
Ala 68 | Gln 68 | engineered mutation |
Ala 69 | Gln 69 | engineered mutation |
Ala 70 | Glu 70 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 22005.7 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 498.0 | |
All* | Total formula weight | 22503.7 |