2ZNV
Crystal structure of human AMSH-LP DUB domain in complex with Lys63-linked ubiquitin dimer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | AMSH-like protease | polymer | 178 | 19916.2 | 2 | UniProt (Q96FJ0) Pfam (PF01398) In PDB | Homo sapiens (human) | AMSH-LP, STAM-binding protein-like 1 |
2 | B, E | Ubiquitin | polymer | 76 | 8604.8 | 2 | UniProt (P62991) Pfam (PF00240) UniProt (by SIFTS) (P0CG50) In PDB | Mus musculus (mouse) | |
3 | C, F | Ubiquitin | polymer | 77 | 8691.9 | 2 | UniProt (P62991) Pfam (PF00240) UniProt (by SIFTS) (P0CG50) In PDB | Mus musculus (mouse) | |
4 | A, D | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
5 | A, B, D | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
6 | water | water | 18.0 | 605 | Chemie (HOH) |
Sequence modifications
A, D: 264 - 436 (UniProt: Q96FJ0)
B, E: 1 - 76 (UniProt: P62991)
C, F: 1 - 76 (UniProt: P62991)
PDB | External Database | Details |
---|---|---|
Gly 259 | - | expression tag |
Pro 260 | - | expression tag |
Gly 261 | - | expression tag |
His 262 | - | expression tag |
Met 263 | - | expression tag |
Ala 292 | Glu 292 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Arg 63 | Lys 63 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Asp 77 | - | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 74426.0 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 317.0 | |
All* | Total formula weight | 74743.0 |