2WZQ

Insertion Mutant E173GP174 of the NS3 protease-helicase from dengue virus

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	NS3 PROTEASE-HELICASE	polymer	619	69576.3	1	UniProt (Q2TN89) Pfam (PF00949) Pfam (PF07652) Pfam (PF20907) UniProt (by SIFTS) (Q2YHF0) In PDB	DENGUE VIRUS
2	C	NS3 PROTEASE-HELICASE	polymer	31	2897.1	1	UniProt (Q2TN89) UniProt (by SIFTS) (Q2YHF0) In PDB	DENGUE VIRUS
3	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
4	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5		water	water		18.0	25	Chemie (HOH)

Sequence modifications

A: 1 - 173 (UniProt: Q2TN89)
A: 175 - 619 (UniProt: Q2TN89)

PDB	External Database	Details
Asp 251	Glu 1724	conflict

A: 174 - 174 (PDB: 2WZQ)
C: 49 - 66 (UniProt: Q2TN89)

PDB	External Database	Details
Asn 58	Ser 1402	conflict
Gly 45	-	expression tag
Ser 46	-	expression tag
Ala 47	-	expression tag
Met 48	-	expression tag
Gly 67	-	expression tag
Gly 68	-	expression tag
Gly 69	-	expression tag
Gly 70	-	expression tag
Ser 71	-	expression tag
Gly 72	-	expression tag
Gly 73	-	expression tag
Gly 74	-	expression tag
Gly 75	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72473.3
Non-Polymers*	Number of molecules	2
	Total formula weight	127.5
All*	Total formula weight	72600.9

*Water molecules are not included.