2WZQ

Insertion Mutant E173GP174 of the NS3 protease-helicase from dengue virus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1620

Chain	Residue
A	ARG388
A	THR409

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1621

Chain	Residue
A	PRO319
A	PRO320
A	GLY321
A	SER322
A	ALA453
A	ASP483
A	LYS516

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860

Chain	Residue	Details
A	HIS51
A	ASP75
A	SER135

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
A	LEU194

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Involved in NS3 ATPase and RTPase activities => ECO:0000250|UniProtKB:P14335

Chain	Residue	Details
A	ARG458
A	ARG461

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P29990

Chain	Residue	Details
A	LYS619

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by host => ECO:0000250|UniProtKB:Q32ZE1

Chain	Residue	Details
A	LYS389

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