2VFX

Structure of the Symmetric Mad2 Dimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A	polymer	206	23516.7	12	UniProt (Q13257) Pfam (PF02301) In PDB	HOMO SAPIENS (HUMAN)	MITOTIC ARREST DEFICIENT 2, MAD2-LIKE 1, HSMAD2
2	K, E, L, A, F...	MAGNESIUM ION	non-polymer		24.3	8	Chemie (MG)
3	C, I, J, D, K...	CHLORIDE ION	non-polymer		35.5	37	Chemie (CL)
4	E, L, A	2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL	non-polymer		354.4	3	Chemie (PE4)
5	C, K, F, G, B...	3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL	non-polymer		634.8	6	Chemie (PE3)
6	I	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
7		water	water		18.0	1591	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 0 - 0 (PDB: 2VFX)
A, B, C, D, E, F, G, H, I, J, K, L: 1 - 205 (UniProt: Q13257)

PDB	External Database	Details
Ala 13	Leu 13	engineered mutation
Ser 79	Cys 79	engineered mutation
Ser 106	Cys 106	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	282200.7
Non-Polymers*	Number of molecules	55
	Total formula weight	6484.1
All*	Total formula weight	288684.8

*Water molecules are not included.