Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2VFX

Structure of the Symmetric Mad2 Dimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000775	cellular_component	chromosome, centromeric region
A	0000776	cellular_component	kinetochore
A	0000922	cellular_component	spindle pole
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007094	biological_process	mitotic spindle assembly checkpoint signaling
A	0033597	cellular_component	mitotic checkpoint complex
A	0042177	biological_process	negative regulation of protein catabolic process
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044615	cellular_component	nuclear pore nuclear basket
A	0045930	biological_process	negative regulation of mitotic cell cycle
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051301	biological_process	cell division
A	0051783	biological_process	regulation of nuclear division
A	0072686	cellular_component	mitotic spindle
A	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
A	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
A	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
A	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
B	0000775	cellular_component	chromosome, centromeric region
B	0000776	cellular_component	kinetochore
B	0000922	cellular_component	spindle pole
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007094	biological_process	mitotic spindle assembly checkpoint signaling
B	0033597	cellular_component	mitotic checkpoint complex
B	0042177	biological_process	negative regulation of protein catabolic process
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0044615	cellular_component	nuclear pore nuclear basket
B	0045930	biological_process	negative regulation of mitotic cell cycle
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051301	biological_process	cell division
B	0051783	biological_process	regulation of nuclear division
B	0072686	cellular_component	mitotic spindle
B	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
B	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
B	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
B	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
C	0000775	cellular_component	chromosome, centromeric region
C	0000776	cellular_component	kinetochore
C	0000922	cellular_component	spindle pole
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0007094	biological_process	mitotic spindle assembly checkpoint signaling
C	0033597	cellular_component	mitotic checkpoint complex
C	0042177	biological_process	negative regulation of protein catabolic process
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0044615	cellular_component	nuclear pore nuclear basket
C	0045930	biological_process	negative regulation of mitotic cell cycle
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051301	biological_process	cell division
C	0051783	biological_process	regulation of nuclear division
C	0072686	cellular_component	mitotic spindle
C	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
C	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
C	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
C	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
D	0000775	cellular_component	chromosome, centromeric region
D	0000776	cellular_component	kinetochore
D	0000922	cellular_component	spindle pole
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0007094	biological_process	mitotic spindle assembly checkpoint signaling
D	0033597	cellular_component	mitotic checkpoint complex
D	0042177	biological_process	negative regulation of protein catabolic process
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0044615	cellular_component	nuclear pore nuclear basket
D	0045930	biological_process	negative regulation of mitotic cell cycle
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0051301	biological_process	cell division
D	0051783	biological_process	regulation of nuclear division
D	0072686	cellular_component	mitotic spindle
D	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
D	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
D	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
D	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
E	0000775	cellular_component	chromosome, centromeric region
E	0000776	cellular_component	kinetochore
E	0000922	cellular_component	spindle pole
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0007094	biological_process	mitotic spindle assembly checkpoint signaling
E	0033597	cellular_component	mitotic checkpoint complex
E	0042177	biological_process	negative regulation of protein catabolic process
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0044615	cellular_component	nuclear pore nuclear basket
E	0045930	biological_process	negative regulation of mitotic cell cycle
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0051301	biological_process	cell division
E	0051783	biological_process	regulation of nuclear division
E	0072686	cellular_component	mitotic spindle
E	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
E	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
E	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
E	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
F	0000775	cellular_component	chromosome, centromeric region
F	0000776	cellular_component	kinetochore
F	0000922	cellular_component	spindle pole
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0007094	biological_process	mitotic spindle assembly checkpoint signaling
F	0033597	cellular_component	mitotic checkpoint complex
F	0042177	biological_process	negative regulation of protein catabolic process
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0044615	cellular_component	nuclear pore nuclear basket
F	0045930	biological_process	negative regulation of mitotic cell cycle
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0051301	biological_process	cell division
F	0051783	biological_process	regulation of nuclear division
F	0072686	cellular_component	mitotic spindle
F	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
F	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
F	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
F	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
G	0000775	cellular_component	chromosome, centromeric region
G	0000776	cellular_component	kinetochore
G	0000922	cellular_component	spindle pole
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0007094	biological_process	mitotic spindle assembly checkpoint signaling
G	0033597	cellular_component	mitotic checkpoint complex
G	0042177	biological_process	negative regulation of protein catabolic process
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0044615	cellular_component	nuclear pore nuclear basket
G	0045930	biological_process	negative regulation of mitotic cell cycle
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0051301	biological_process	cell division
G	0051783	biological_process	regulation of nuclear division
G	0072686	cellular_component	mitotic spindle
G	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
G	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
G	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
G	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
H	0000775	cellular_component	chromosome, centromeric region
H	0000776	cellular_component	kinetochore
H	0000922	cellular_component	spindle pole
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0007094	biological_process	mitotic spindle assembly checkpoint signaling
H	0033597	cellular_component	mitotic checkpoint complex
H	0042177	biological_process	negative regulation of protein catabolic process
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0044615	cellular_component	nuclear pore nuclear basket
H	0045930	biological_process	negative regulation of mitotic cell cycle
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0051301	biological_process	cell division
H	0051783	biological_process	regulation of nuclear division
H	0072686	cellular_component	mitotic spindle
H	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
H	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
H	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
H	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
I	0000775	cellular_component	chromosome, centromeric region
I	0000776	cellular_component	kinetochore
I	0000922	cellular_component	spindle pole
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005694	cellular_component	chromosome
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0007094	biological_process	mitotic spindle assembly checkpoint signaling
I	0033597	cellular_component	mitotic checkpoint complex
I	0042177	biological_process	negative regulation of protein catabolic process
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0044615	cellular_component	nuclear pore nuclear basket
I	0045930	biological_process	negative regulation of mitotic cell cycle
I	0048471	cellular_component	perinuclear region of cytoplasm
I	0051301	biological_process	cell division
I	0051783	biological_process	regulation of nuclear division
I	0072686	cellular_component	mitotic spindle
I	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
I	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
I	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
I	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
J	0000775	cellular_component	chromosome, centromeric region
J	0000776	cellular_component	kinetochore
J	0000922	cellular_component	spindle pole
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005694	cellular_component	chromosome
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0007094	biological_process	mitotic spindle assembly checkpoint signaling
J	0033597	cellular_component	mitotic checkpoint complex
J	0042177	biological_process	negative regulation of protein catabolic process
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0044615	cellular_component	nuclear pore nuclear basket
J	0045930	biological_process	negative regulation of mitotic cell cycle
J	0048471	cellular_component	perinuclear region of cytoplasm
J	0051301	biological_process	cell division
J	0051783	biological_process	regulation of nuclear division
J	0072686	cellular_component	mitotic spindle
J	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
J	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
J	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
J	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
K	0000775	cellular_component	chromosome, centromeric region
K	0000776	cellular_component	kinetochore
K	0000922	cellular_component	spindle pole
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005694	cellular_component	chromosome
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0007094	biological_process	mitotic spindle assembly checkpoint signaling
K	0033597	cellular_component	mitotic checkpoint complex
K	0042177	biological_process	negative regulation of protein catabolic process
K	0042802	molecular_function	identical protein binding
K	0042803	molecular_function	protein homodimerization activity
K	0044615	cellular_component	nuclear pore nuclear basket
K	0045930	biological_process	negative regulation of mitotic cell cycle
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0051301	biological_process	cell division
K	0051783	biological_process	regulation of nuclear division
K	0072686	cellular_component	mitotic spindle
K	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
K	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
K	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
K	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
L	0000775	cellular_component	chromosome, centromeric region
L	0000776	cellular_component	kinetochore
L	0000922	cellular_component	spindle pole
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005694	cellular_component	chromosome
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0007094	biological_process	mitotic spindle assembly checkpoint signaling
L	0033597	cellular_component	mitotic checkpoint complex
L	0042177	biological_process	negative regulation of protein catabolic process
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0044615	cellular_component	nuclear pore nuclear basket
L	0045930	biological_process	negative regulation of mitotic cell cycle
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0051301	biological_process	cell division
L	0051783	biological_process	regulation of nuclear division
L	0072686	cellular_component	mitotic spindle
L	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
L	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
L	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
L	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A1206

Chain	Residue
A	ASP205
A	HOH2139
A	HOH2143
A	HOH2144
D	ASP205

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B1206

Chain	Residue
B	ASP205
B	HOH2126
B	HOH2130

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C1206

Chain	Residue
C	HOH2119
I	ASP205
I	HOH2133
I	HOH2137
C	ASP205

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG E1206

Chain	Residue
E	ASP205
E	HOH2129
E	HOH2131
H	ASP205
H	HOH2117
H	HOH2118

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG F1206

Chain	Residue
F	ASP205
F	HOH2126
F	HOH2129
F	HOH2130
J	ASP205

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG G1206

Chain	Residue
G	ASP205
G	HOH2125
G	HOH2129
G	HOH2130

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG K1206

Chain	Residue
K	ASP205
K	HOH2134
K	HOH2138
K	HOH2139

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG L1206

Chain	Residue
L	ASP205
L	HOH2121
L	HOH2125
L	HOH2127

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL E1207

Chain	Residue
E	ARG99
E	PHE174
E	ILE175
H	LYS192
H	HOH2061

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E3102

Chain	Residue
B	ARG99
B	ILE175
E	LYS192
E	HOH2069

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL I3103

Chain	Residue
I	LYS192
I	HOH2073
L	ARG99
L	PHE174
L	ILE175

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL J3104

Chain	Residue
J	LYS192
J	HOH2074
K	ARG99
K	ILE175

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL D1206

Chain	Residue
D	LYS192
D	HOH2077
G	ARG99
G	PHE174
G	ILE175

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL I1206

Chain	Residue
C	LYS192
I	ARG99
I	PHE174
I	ILE175

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A1207

Chain	Residue
A	ARG99
A	ILE175
G	LYS192

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL J1206

Chain	Residue
F	LYS192
F	HOH2066
J	ARG99
J	PHE174
J	ILE175

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL F1207

Chain	Residue
F	ARG99
F	ILE175
K	LYS192
K	HOH2076

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL D1207

Chain	Residue
A	LYS192
A	HOH2077
D	ARG99
D	PHE174
D	ILE175

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL B3111

Chain	Residue
B	LYS192
B	HOH2074
H	ARG99
H	PHE174
H	ILE175

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G1207

Chain	Residue
A	SER178
G	SER185
G	LYS192

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL L1207

Chain	Residue
C	ARG99
C	PHE174
C	ILE175
L	LYS192
L	HOH2069

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C1207

Chain	Residue
C	ALA137
C	HOH2079

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E1208

Chain	Residue
E	SER178
H	SER185
H	LYS192

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D1208

Chain	Residue
A	LYS192
A	HOH2131
D	SER178
A	SER185

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL J1207

Chain	Residue
F	SER185
F	LYS192
J	SER178

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL B1207

Chain	Residue
B	ARG182
B	SER185
B	LYS192
H	SER178
H	HOH2095

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL K1207

Chain	Residue
F	SER178
K	SER185
K	LYS192

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D1209

Chain	Residue
D	SER185
D	LYS192
G	SER178

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL L1208

Chain	Residue
I	SER185
I	LYS192
L	SER178

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C1208

Chain	Residue
C	SER178
L	SER185
L	LYS192

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL I1207

Chain	Residue
C	SER185
C	LYS192
I	SER178

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL K1208

Chain	Residue
J	SER185
J	LYS192
K	SER178

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B1208

Chain	Residue
B	SER178
E	SER185
E	LYS192

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C1209

Chain	Residue
C	ARG99
C	GLN101
C	HOH2059

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL I1208

Chain	Residue
I	ALA137
I	HOH2038
I	HOH2092
L	ALA137

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B1209

Chain	Residue
E	ALA137
E	HOH2090

site_id	EC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E1209

Chain	Residue
E	SER40

site_id	EC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D1210

Chain	Residue
D	ALA137
D	HOH2037

site_id	EC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL J1208

Chain	Residue
J	ALA137
K	HOH2093

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PE4 L1209

Chain	Residue
L	TYR33
L	GLN34
L	GLY36
L	LEU145
L	VAL147
L	HOH2128

site_id	EC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PE3 C1210

Chain	Residue
C	GLN34
C	LEU145
C	VAL147
C	HOH2120
C	HOH2121

site_id	EC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PE3 F1208

Chain	Residue
F	TYR33
F	ARG35
F	GLY36
F	LEU145
F	HOH2131

site_id	EC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PE3 H3104

Chain	Residue
H	GLN34
H	ARG35
H	GLY36
H	LEU145
H	VAL147

site_id	EC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PE3 G1208

Chain	Residue
G	GLN34
G	LEU145

site_id	EC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PE3 B1210

Chain	Residue
B	GLN34
B	ARG35
B	LEU145
B	VAL147
B	HOH2020
B	HOH2132

site_id	FC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG I1209

Chain	Residue
I	TYR33
I	GLN34
I	ARG35
I	LEU145

site_id	FC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PE3 K1209

Chain	Residue
K	TYR33
K	GLN34
K	GLY36
K	LEU145

site_id	FC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PE4 A1210

Chain	Residue
A	GLN34
A	ARG35
A	GLY36
A	LEU145
A	VAL147
A	SER148
A	HOH2145

site_id	FC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PE4 E1210

Chain	Residue
E	TYR33
E	GLY36
E	LEU145
E	HOH2018

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	Region: {"description":"Required for assuming the closed conformation and for interaction with CDC20"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Dhillon A.S.","Kolch W."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	36
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	24
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"12574116","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"12574116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	366
Details	Domain: {"description":"HORMA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00109","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)