2R5P
Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Indinavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Protease | polymer | 99 | 10751.8 | 4 | UniProt (Q50CM2) Pfam (PF00077) UniProt (by SIFTS) (O12158) | Human immunodeficiency virus 1 | |
| 2 | E, F, I, J (A, B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 3 | G (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | H, K (B, D) | N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE | non-polymer | 613.8 | 2 | Chemie (MK1) | |||
| 5 | L, M, N, O (A, B, C, D) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 99 (UniProt: Q50CM2)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
| Ile 33 | Leu 33 | engineered mutation |
| Ala 37 | Asn 37 | conflict |
| Ile 63 | Leu 63 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43007.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1392.4 | |
| All* | Total formula weight | 44399.5 |
