2QOS

Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site on C8

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (C)	Complement component 8, gamma polypeptide	polymer	173	19171.6	1	UniProt (Q14CU0) Pfam (PF00061) UniProt (by SIFTS) (P07360)	Homo sapiens (human)
2	B (A)	Complement component C8 alpha chain	polymer	11	1388.5	1	UniProt (P07357)		Complement component 8 subunit alpha
3	C, D (C, A)	water	water		18.0	164	Chemie (HOH)

Sequence modifications

C: 10 - 182 (UniProt: Q14CU0)

PDB	External Database	Details
Ala 40	Cys 60	engineered mutation

A: 158 - 168 (UniProt: P07357)

PDB	External Database	Details
Ala 164	Cys 194	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	20560.2
All*	Total formula weight	20560.2

*Water molecules are not included.