2NZ6
Crystal structure of the PTPRJ inactivating mutant C1239S
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Receptor-type tyrosine-protein phosphatase eta | polymer | 316 | 36866.6 | 1 | UniProt (Q12913) Pfam (PF00102) In PDB | Homo sapiens (human) | Protein-tyrosine phosphatase eta, R-PTP-eta, HPTP eta, Protein- tyrosine phosphatase receptor type J, Density-enhanced phosphatase 1, DEP-1, CD148 antigen |
| 2 | A | NICKEL (II) ION | non-polymer | 58.7 | 5 | Chemie (NI) | |||
| 3 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A: 1019 - 1311 (UniProt: Q12913)
| PDB | External Database | Details |
|---|---|---|
| Met -22 | - | cloning artifact |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| Ser -15 | - | cloning artifact |
| Ser -14 | - | cloning artifact |
| Gly -13 | - | cloning artifact |
| Val -12 | - | cloning artifact |
| Asp -11 | - | cloning artifact |
| Leu -10 | - | cloning artifact |
| Gly -9 | - | cloning artifact |
| Thr -8 | - | cloning artifact |
| Glu -7 | - | cloning artifact |
| Asn -6 | - | cloning artifact |
| Leu -5 | - | cloning artifact |
| Tyr -4 | - | cloning artifact |
| Phe -3 | - | cloning artifact |
| Gln -2 | - | cloning artifact |
| Ser -1 | - | cloning artifact |
| Met 0 | - | cloning artifact |
| Ser 1239 | Cys 1239 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36866.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 423.9 | |
| All* | Total formula weight | 37290.4 |
