2NZ6

Crystal structure of the PTPRJ inactivating mutant C1239S

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI A 201

Chain	Residue
A	HIS-18
A	HIS-18
A	HIS-16
A	HIS-16
A	HIS-16
A	HIS-18

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NI A 203

Chain	Residue
A	HIS1206

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NI A 204

Chain	Residue
A	HIS-21
A	HIS-19
A	HIS-20

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI A 205

Chain	Residue
A	HIS-21
A	HIS-19
A	HIS-17
A	LYS1106
A	HIS1277

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI A 206

Chain	Residue
A	HIS-20
A	HIS-20
A	HIS-20
A	HOH96
A	HOH96
A	HOH96

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 207

Chain	Residue
A	HOH45
A	ASP1205
A	SER1239
A	SER1240
A	ALA1241
A	GLY1242
A	VAL1243
A	GLY1244
A	ARG1245
A	TYR1311

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10044","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1d5r

Chain	Residue	Details
A	ARG1245

---