2NN6
Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Polymyositis/scleroderma autoantigen 1 | polymer | 358 | 39405.8 | 1 | UniProt (Q86Y41) Pfam (PF01138) Pfam (PF03725) UniProt (by SIFTS) (Q06265) In PDB | Homo sapiens (human) | Ribosomal RNA-processing protein 45, Rrp45, PM/Scl-75 |
| 2 | B | Exosome complex exonuclease RRP41 | polymer | 249 | 26831.5 | 1 | UniProt (Q9NPD3) Pfam (PF01138) Pfam (PF03725) In PDB | Homo sapiens (human) | Ribosomal RNA-processing protein 41, Exosome component 4, p12A |
| 3 | C | Exosome complex exonuclease RRP43 | polymer | 278 | 30285.8 | 1 | UniProt (Q96B26) Pfam (PF01138) Pfam (PF03725) In PDB | Homo sapiens (human) | Ribosomal RNA-processing protein 43, Exosome component 8, p9, Opa-interacting protein 2, OIP2 |
| 4 | D | Exosome complex exonuclease RRP46 | polymer | 237 | 25480.2 | 1 | UniProt (Q9NQT4) Pfam (PF01138) Pfam (PF03725) In PDB | Homo sapiens (human) | Ribosomal RNA-processing protein 46, Exosome component 5, p12B, Chronic myelogenous leukemia tumor antigen 28 |
| 5 | E | Exosome complex exonuclease RRP42 | polymer | 305 | 33479.1 | 1 | UniProt (Q15024) Pfam (PF03725) Pfam (PF01138) In PDB | Homo sapiens (human) | Ribosomal RNA-processing protein 42, Exosome component 7, p8 |
| 6 | F | Exosome component 6 | polymer | 272 | 28267.1 | 1 | UniProt (Q5RKV6) Pfam (PF01138) In PDB | Homo sapiens (human) | Mtr3 |
| 7 | G | Exosome complex exonuclease RRP40 | polymer | 289 | 31227.9 | 1 | UniProt (Q9NQT5) Pfam (PF21261) Pfam (PF21262) Pfam (PF15985) In PDB | Homo sapiens (human) | Ribosomal RNA-processing protein 40, Exosome component 3, p10 |
| 8 | H | Exosome complex exonuclease RRP4 | polymer | 308 | 34590.9 | 1 | UniProt (Q13868) Pfam (PF14382) Pfam (PF21266) Pfam (PF15985) In PDB | Homo sapiens (human) | Ribosomal RNA-processing protein 4, Exosome component 2 |
| 9 | I | 3'-5' exoribonuclease CSL4 homolog | polymer | 209 | 23097.5 | 1 | UniProt (Q9Y3B2) Pfam (PF14382) Pfam (PF10447) In PDB | Homo sapiens (human) | Exosome component 1 |
Sequence modifications
A: 1 - 302 (UniProt: Q86Y41)
B: 1 - 244 (UniProt: Q9NPD3)
C: 1 - 276 (UniProt: Q96B26)
D: 1 - 235 (UniProt: Q9NQT4)
E: 1 - 291 (UniProt: Q15024)
G: 0 - 274 (UniProt: Q9NQT5)
H: 1 - 293 (UniProt: Q13868)
I: 1 - 195 (UniProt: Q9Y3B2)
| PDB | External Database | Details |
|---|---|---|
| Met -16 | - | cloning artifact |
| Gly -15 | - | cloning artifact |
| Ser -14 | - | cloning artifact |
| Ser -13 | - | cloning artifact |
| His -12 | - | cloning artifact |
| His -11 | - | cloning artifact |
| His -10 | - | cloning artifact |
| His -9 | - | cloning artifact |
| His -8 | - | cloning artifact |
| His -7 | - | cloning artifact |
| Ser -6 | - | cloning artifact |
| Gln -5 | - | cloning artifact |
| Asp -4 | - | cloning artifact |
| Pro -3 | - | cloning artifact |
| Asn -2 | - | cloning artifact |
| Ser -1 | - | cloning artifact |
| His 0 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | cloning artifact |
| Ala -3 | - | cloning artifact |
| Asp -2 | - | cloning artifact |
| Pro -1 | - | cloning artifact |
| Met 0 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Asp -1 | - | cloning artifact |
| Pro 0 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | cloning artifact |
| Leu 0 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | cloning artifact |
| Gly -12 | - | cloning artifact |
| Ser -11 | - | cloning artifact |
| Ser -10 | - | cloning artifact |
| His -9 | - | cloning artifact |
| His -8 | - | cloning artifact |
| His -7 | - | cloning artifact |
| His -6 | - | cloning artifact |
| His -5 | - | cloning artifact |
| His -4 | - | cloning artifact |
| Ser -3 | - | cloning artifact |
| Gln -2 | - | cloning artifact |
| Asp -1 | - | cloning artifact |
| Pro 0 | - | cloning artifact |
| Val 274 | Leu 274 | variant |
| PDB | External Database | Details |
|---|---|---|
| Met -14 | - | cloning artifact |
| Gly -13 | - | cloning artifact |
| Ser -12 | - | cloning artifact |
| Ser -11 | - | cloning artifact |
| His -10 | - | cloning artifact |
| His -9 | - | cloning artifact |
| His -8 | - | cloning artifact |
| His -7 | - | cloning artifact |
| His -6 | - | cloning artifact |
| His -5 | - | cloning artifact |
| Ser -4 | - | cloning artifact |
| Gln -3 | - | cloning artifact |
| Asp -2 | - | cloning artifact |
| Pro -1 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Met -14 | - | cloning artifact |
| Gly -13 | - | cloning artifact |
| Ser -12 | - | cloning artifact |
| Ser -11 | - | cloning artifact |
| His -10 | - | cloning artifact |
| His -9 | - | cloning artifact |
| His -8 | - | cloning artifact |
| His -7 | - | cloning artifact |
| His -6 | - | cloning artifact |
| His -5 | - | cloning artifact |
| Ser -4 | - | cloning artifact |
| Gln -3 | - | cloning artifact |
| Asp -2 | - | cloning artifact |
| Pro -1 | - | cloning artifact |
| His 0 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | cloning artifact |
| Gly -12 | - | cloning artifact |
| Ser -11 | - | cloning artifact |
| Ser -10 | - | cloning artifact |
| His -9 | - | cloning artifact |
| His -8 | - | cloning artifact |
| His -7 | - | cloning artifact |
| His -6 | - | cloning artifact |
| His -5 | - | cloning artifact |
| His -4 | - | cloning artifact |
| Ser -3 | - | cloning artifact |
| Gln -2 | - | cloning artifact |
| Asp -1 | - | cloning artifact |
| Pro 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 272665.7 | |
| All* | Total formula weight | 272665.7 |
