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2NN6

Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40

Functional Information from GO Data
ChainGOidnamespacecontents
A0000178cellular_componentexosome (RNase complex)
A0006396biological_processRNA processing
B0000175molecular_function3'-5'-RNA exonuclease activity
B0000176cellular_componentnuclear exosome (RNase complex)
B0000177cellular_componentcytoplasmic exosome (RNase complex)
B0000178cellular_componentexosome (RNase complex)
B0000460biological_processmaturation of 5.8S rRNA
B0000791cellular_componenteuchromatin
B0000956biological_processnuclear-transcribed mRNA catabolic process
B0003723molecular_functionRNA binding
B0004532molecular_functionRNA exonuclease activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006364biological_processrRNA processing
B0006396biological_processRNA processing
B0006401biological_processRNA catabolic process
B0016075biological_processrRNA catabolic process
B0030307biological_processpositive regulation of cell growth
B0034427biological_processobsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
B0034475biological_processU4 snRNA 3'-end processing
B0035925molecular_functionmRNA 3'-UTR AU-rich region binding
B0043231cellular_componentintracellular membrane-bounded organelle
B0045006biological_processDNA deamination
B0051607biological_processdefense response to virus
B0071028biological_processnuclear mRNA surveillance
B0071044biological_processhistone mRNA catabolic process
B0071051biological_processpoly(A)-dependent snoRNA 3'-end processing
B0101019cellular_componentnucleolar exosome (RNase complex)
B1902494cellular_componentcatalytic complex
C0000176cellular_componentnuclear exosome (RNase complex)
C0000177cellular_componentcytoplasmic exosome (RNase complex)
C0000178cellular_componentexosome (RNase complex)
C0000467biological_processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C0001650cellular_componentfibrillar center
C0003723molecular_functionRNA binding
C0004532molecular_functionRNA exonuclease activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006364biological_processrRNA processing
C0006396biological_processRNA processing
C0006401biological_processRNA catabolic process
C0034427biological_processobsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
C0034473biological_processU1 snRNA 3'-end processing
C0034475biological_processU4 snRNA 3'-end processing
C0034476biological_processU5 snRNA 3'-end processing
C0035925molecular_functionmRNA 3'-UTR AU-rich region binding
C0042802molecular_functionidentical protein binding
C0043231cellular_componentintracellular membrane-bounded organelle
C0043928biological_processobsolete exonucleolytic catabolism of deadenylated mRNA
C0071028biological_processnuclear mRNA surveillance
C0071035biological_processnuclear polyadenylation-dependent rRNA catabolic process
C0071038biological_processTRAMP-dependent tRNA surveillance pathway
C0071042biological_processnuclear polyadenylation-dependent mRNA catabolic process
C0101019cellular_componentnucleolar exosome (RNase complex)
C1902494cellular_componentcatalytic complex
D0000175molecular_function3'-5'-RNA exonuclease activity
D0000176cellular_componentnuclear exosome (RNase complex)
D0000177cellular_componentcytoplasmic exosome (RNase complex)
D0000178cellular_componentexosome (RNase complex)
D0000791cellular_componenteuchromatin
D0003677molecular_functionDNA binding
D0004532molecular_functionRNA exonuclease activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006364biological_processrRNA processing
D0006396biological_processRNA processing
D0006401biological_processRNA catabolic process
D0016075biological_processrRNA catabolic process
D0034427biological_processobsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
D0034475biological_processU4 snRNA 3'-end processing
D0043928biological_processobsolete exonucleolytic catabolism of deadenylated mRNA
D0045006biological_processDNA deamination
D0051607biological_processdefense response to virus
D0071028biological_processnuclear mRNA surveillance
D0071051biological_processpoly(A)-dependent snoRNA 3'-end processing
D0101019cellular_componentnucleolar exosome (RNase complex)
D1902494cellular_componentcatalytic complex
E0000175molecular_function3'-5'-RNA exonuclease activity
E0000176cellular_componentnuclear exosome (RNase complex)
E0000177cellular_componentcytoplasmic exosome (RNase complex)
E0000178cellular_componentexosome (RNase complex)
E0000467biological_processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E0003723molecular_functionRNA binding
E0004532molecular_functionRNA exonuclease activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005730cellular_componentnucleolus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006364biological_processrRNA processing
E0006396biological_processRNA processing
E0006401biological_processRNA catabolic process
E0034427biological_processobsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
E0034473biological_processU1 snRNA 3'-end processing
E0034475biological_processU4 snRNA 3'-end processing
E0034476biological_processU5 snRNA 3'-end processing
E0043928biological_processobsolete exonucleolytic catabolism of deadenylated mRNA
E0071028biological_processnuclear mRNA surveillance
E0071035biological_processnuclear polyadenylation-dependent rRNA catabolic process
E0071038biological_processTRAMP-dependent tRNA surveillance pathway
E0071042biological_processnuclear polyadenylation-dependent mRNA catabolic process
E0101019cellular_componentnucleolar exosome (RNase complex)
E1902494cellular_componentcatalytic complex
F0000176cellular_componentnuclear exosome (RNase complex)
F0000177cellular_componentcytoplasmic exosome (RNase complex)
F0000178cellular_componentexosome (RNase complex)
F0003723molecular_functionRNA binding
F0004532molecular_functionRNA exonuclease activity
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006364biological_processrRNA processing
F0006396biological_processRNA processing
F0006401biological_processRNA catabolic process
F0016075biological_processrRNA catabolic process
F0034427biological_processobsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
F0034475biological_processU4 snRNA 3'-end processing
F0045006biological_processDNA deamination
F0045190biological_processisotype switching
F0045830biological_processpositive regulation of isotype switching
F0071028biological_processnuclear mRNA surveillance
F0071051biological_processpoly(A)-dependent snoRNA 3'-end processing
F0101019cellular_componentnucleolar exosome (RNase complex)
F1902494cellular_componentcatalytic complex
G0000175molecular_function3'-5'-RNA exonuclease activity
G0000176cellular_componentnuclear exosome (RNase complex)
G0000177cellular_componentcytoplasmic exosome (RNase complex)
G0000178cellular_componentexosome (RNase complex)
G0000467biological_processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G0000791cellular_componenteuchromatin
G0003723molecular_functionRNA binding
G0004532molecular_functionRNA exonuclease activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005730cellular_componentnucleolus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006364biological_processrRNA processing
G0006396biological_processRNA processing
G0006401biological_processRNA catabolic process
G0034427biological_processobsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
G0034475biological_processU4 snRNA 3'-end processing
G0043928biological_processobsolete exonucleolytic catabolism of deadenylated mRNA
G0045006biological_processDNA deamination
G0045190biological_processisotype switching
G0045830biological_processpositive regulation of isotype switching
G0071034biological_processCUT catabolic process
G0071035biological_processnuclear polyadenylation-dependent rRNA catabolic process
G0071038biological_processTRAMP-dependent tRNA surveillance pathway
G0071051biological_processpoly(A)-dependent snoRNA 3'-end processing
G0101019cellular_componentnucleolar exosome (RNase complex)
H0000175molecular_function3'-5'-RNA exonuclease activity
H0000176cellular_componentnuclear exosome (RNase complex)
H0000177cellular_componentcytoplasmic exosome (RNase complex)
H0000178cellular_componentexosome (RNase complex)
H0000467biological_processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0003723molecular_functionRNA binding
H0004532molecular_functionRNA exonuclease activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005730cellular_componentnucleolus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006364biological_processrRNA processing
H0006396biological_processRNA processing
H0006401biological_processRNA catabolic process
H0008312molecular_function7S RNA binding
H0030307biological_processpositive regulation of cell growth
H0034427biological_processobsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
H0034475biological_processU4 snRNA 3'-end processing
H0043928biological_processobsolete exonucleolytic catabolism of deadenylated mRNA
H0071034biological_processCUT catabolic process
H0071035biological_processnuclear polyadenylation-dependent rRNA catabolic process
H0071038biological_processTRAMP-dependent tRNA surveillance pathway
H0071051biological_processpoly(A)-dependent snoRNA 3'-end processing
H0101019cellular_componentnucleolar exosome (RNase complex)
I0000176cellular_componentnuclear exosome (RNase complex)
I0000177cellular_componentcytoplasmic exosome (RNase complex)
I0000178cellular_componentexosome (RNase complex)
I0003676molecular_functionnucleic acid binding
I0003723molecular_functionRNA binding
I0004532molecular_functionRNA exonuclease activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005730cellular_componentnucleolus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006364biological_processrRNA processing
I0006396biological_processRNA processing
I0006401biological_processRNA catabolic process
I0101019cellular_componentnucleolar exosome (RNase complex)
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ISER21

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ISER98

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ESER177

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PDB entries from 2024-04-24

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