2BBZ

Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Viral CASP8 and FADD-like apoptosis regulator	polymer	249	28038.9	4	UniProt (Q98325) Pfam (PF01335) In PDB	Molluscum contagiosum virus subtype 1	v-CFLAR, Viral FLICE-inhibitory protein, v-FLIP
2		water	water		18.0	52	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 241 (UniProt: Q98325)

PDB	External Database	Details
Leu 242	-	expression tag
Glu 243	-	expression tag
His 244	-	expression tag
His 245	-	expression tag
His 246	-	expression tag
His 247	-	expression tag
His 248	-	expression tag
His 249	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	112155.7
All*	Total formula weight	112155.7

*Water molecules are not included.