2BBZ

Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0030430	cellular_component	host cell cytoplasm
A	0033668	biological_process	symbiont-mediated suppression of host apoptosis
A	0042025	cellular_component	host cell nucleus
A	0042981	biological_process	regulation of apoptotic process
A	0052150	biological_process	symbiont-mediated perturbation of host apoptosis
A	0060545	biological_process	positive regulation of necroptotic process
A	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
A	0140321	biological_process	symbiont-mediated suppression of host autophagy
A	2001234	biological_process	negative regulation of apoptotic signaling pathway
B	0005515	molecular_function	protein binding
B	0030430	cellular_component	host cell cytoplasm
B	0033668	biological_process	symbiont-mediated suppression of host apoptosis
B	0042025	cellular_component	host cell nucleus
B	0042981	biological_process	regulation of apoptotic process
B	0052150	biological_process	symbiont-mediated perturbation of host apoptosis
B	0060545	biological_process	positive regulation of necroptotic process
B	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
B	0140321	biological_process	symbiont-mediated suppression of host autophagy
B	2001234	biological_process	negative regulation of apoptotic signaling pathway
C	0005515	molecular_function	protein binding
C	0030430	cellular_component	host cell cytoplasm
C	0033668	biological_process	symbiont-mediated suppression of host apoptosis
C	0042025	cellular_component	host cell nucleus
C	0042981	biological_process	regulation of apoptotic process
C	0052150	biological_process	symbiont-mediated perturbation of host apoptosis
C	0060545	biological_process	positive regulation of necroptotic process
C	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
C	0140321	biological_process	symbiont-mediated suppression of host autophagy
C	2001234	biological_process	negative regulation of apoptotic signaling pathway
D	0005515	molecular_function	protein binding
D	0030430	cellular_component	host cell cytoplasm
D	0033668	biological_process	symbiont-mediated suppression of host apoptosis
D	0042025	cellular_component	host cell nucleus
D	0042981	biological_process	regulation of apoptotic process
D	0052150	biological_process	symbiont-mediated perturbation of host apoptosis
D	0060545	biological_process	positive regulation of necroptotic process
D	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
D	0140321	biological_process	symbiont-mediated suppression of host autophagy
D	2001234	biological_process	negative regulation of apoptotic signaling pathway

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	280
Details	Domain: {"description":"DED 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00065","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16317000","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	320
Details	Domain: {"description":"DED 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00065","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16317000","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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