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2A5F

Cholera toxin A1 subunit bound to its substrate, NAD+, and its human protein activator, ARF6

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
ADP-ribosylation factor 6polymer17520110.21UniProt (P62330)
Pfam (PF00025)
Homo sapiens (human)
2B
(B)
Cholera enterotoxin, A chainpolymer19321710.81UniProt (P01555)
Pfam (PF01375)
Vibrio choleraeNAD(+)--diphthamide ADP-ribosyltransferase, Cholera enterotoxin A subunit
3C
(A)
MAGNESIUM IONnon-polymer24.31Chemie (MG)
4D
(A)
GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
5E
(B)
SODIUM IONnon-polymer23.01Chemie (NA)
6F
(B)
NICOTINAMIDE-ADENINE-DINUCLEOTIDEnon-polymer663.41Chemie (NAD)
7G
(B)
GLYCEROLnon-polymer92.11Chemie (GOL)
8H, I
(A, B)
waterwater18.0169Chemie (HOH)
Sequence modifications
A: 2 - 175 (UniProt: P62330)
PDBExternal DatabaseDetails
Met 1-initiating methionine
B: 1 - 192 (UniProt: P01555)
PDBExternal DatabaseDetails
Ser 0-cloning artifact
Asp 110Glu 128engineered mutation
Asp 112Glu 130engineered mutation
Ser 187Cys 205engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight41820.9
Non-Polymers*Number of molecules5
Total formula weight1326.0
All*Total formula weight43146.9
*Water molecules are not included.

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PDB entries from 2024-10-30

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