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2A5F

Cholera toxin A1 subunit bound to its substrate, NAD+, and its human protein activator, ARF6

Functional Information from GO Data
ChainGOidnamespacecontents
A0001726cellular_componentruffle
A0001889biological_processliver development
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006886biological_processintracellular protein transport
A0007155biological_processcell adhesion
A0007399biological_processnervous system development
A0010975biological_processregulation of neuron projection development
A0010976biological_processpositive regulation of neuron projection development
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016192biological_processvesicle-mediated transport
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0030139cellular_componentendocytic vesicle
A0030154biological_processcell differentiation
A0030496cellular_componentmidbody
A0030838biological_processpositive regulation of actin filament polymerization
A0030866biological_processcortical actin cytoskeleton organization
A0031527cellular_componentfilopodium membrane
A0031901cellular_componentearly endosome membrane
A0031996molecular_functionthioesterase binding
A0032154cellular_componentcleavage furrow
A0032456biological_processendocytic recycling
A0034394biological_processprotein localization to cell surface
A0035020biological_processregulation of Rac protein signal transduction
A0035591molecular_functionsignaling adaptor activity
A0036010biological_processprotein localization to endosome
A0042995cellular_componentcell projection
A0048261biological_processnegative regulation of receptor-mediated endocytosis
A0048488biological_processsynaptic vesicle endocytosis
A0050714biological_processpositive regulation of protein secretion
A0051301biological_processcell division
A0051489biological_processregulation of filopodium assembly
A0051549biological_processpositive regulation of keratinocyte migration
A0055037cellular_componentrecycling endosome
A0055038cellular_componentrecycling endosome membrane
A0060998biological_processregulation of dendritic spine development
A0070062cellular_componentextracellular exosome
A0072659biological_processprotein localization to plasma membrane
A0090162biological_processestablishment of epithelial cell polarity
A0090543cellular_componentFlemming body
A0097178biological_processruffle assembly
A0097284biological_processhepatocyte apoptotic process
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099562biological_processmaintenance of postsynaptic density structure
A0120183biological_processpositive regulation of focal adhesion disassembly
A1902217biological_processerythrocyte apoptotic process
A1903078biological_processpositive regulation of protein localization to plasma membrane
A1903438biological_processpositive regulation of mitotic cytokinetic process
A1905345biological_processprotein localization to cleavage furrow
A1905606biological_processregulation of presynapse assembly
A1990090biological_processcellular response to nerve growth factor stimulus
A2000009biological_processnegative regulation of protein localization to cell surface
A2000171biological_processnegative regulation of dendrite development
B0005615cellular_componentextracellular space
B0090729molecular_functiontoxin activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 231
ChainResidue
ATHR27
ATHR44
AGTP230
AHOH274
AHOH291

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NA B 1326
ChainResidue
BHOH1641
BTHR90
BTYR150
BLEU153
BHOH1597

site_idAC3
Number of Residues23
DetailsBINDING SITE FOR RESIDUE GTP A 230
ChainResidue
AASP22
AALA23
AALA24
AGLY25
ALYS26
ATHR27
ATHR28
ATHR41
ATHR44
AGLY65
AGLY66
AASN122
ALYS123
AASP125
ALEU126
ACYS155
AALA156
ATHR157
AMG231
AHOH274
AHOH276
AHOH291
AHOH1108

site_idAC4
Number of Residues19
DetailsBINDING SITE FOR RESIDUE NAD B 1536
ChainResidue
BARG7
BALA8
BASP9
BSER10
BARG11
BMET23
BPRO24
BARG25
BSER61
BTHR62
BSER63
BVAL72
BLEU77
BASP110
BASP112
BHOH242
BHOH293
BHOH295
BGOL1114

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 1114
ChainResidue
BARG7
BHIS44
BVAL53
BASP57
BTYR59
BVAL60
BSER61
BNAD1536

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
BASP112
AILE42
AVAL64
ALYS123
AALA156

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:16099990
ChainResidueDetails
BARG7
BMET23

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: N6-myristoyl lysine => ECO:0000269|PubMed:32103017
ChainResidueDetails
AVAL4

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1xtc
ChainResidueDetails
BSER61
BARG7
BASP112
BASP110

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1xtc
ChainResidueDetails
AGLN67

site_idMCSA1
Number of Residues4
DetailsM-CSA 919
ChainResidueDetails
BARG7electrostatic stabiliser
BSER61electrostatic stabiliser
BASP110proton shuttle (general acid/base)
BASP112electrostatic stabiliser

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PDB entries from 2024-10-30

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