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1XSP

Crystal Structure of human DNA polymerase lambda in complex with nicked DNA and pyrophosphate

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(T)
5'-D(*CP*GP*GP*CP*CP*GP*TP*AP*CP*TP*G)-3'polymer113350.21
2B
(P)
5'-D(*CP*AP*GP*TP*AP*CP*G)-3'polymer72122.41
3C
(D)
5'-D(P*GP*CP*CP*G)-3'polymer41191.81
4D
(A)
DNA polymerase lambdapolymer33537447.71UniProt (Q9UGP5)
Pfam (PF14716)
Pfam (PF10391)
Pfam (PF14792)
Pfam (PF14791)
Homo sapiens (human)Pol Lambda, DNA polymerase beta-2, Pol beta2
5E, F, G, H
(D, A)
SODIUM IONnon-polymer23.04Chemie (NA)
6I
(A)
PYROPHOSPHATEnon-polymer178.01Chemie (PPV)
7J, K, L, M
(T, P, D, A)
waterwater18.0334Chemie (HOH)
Sequence modifications
A: 242 - 575 (UniProt: Q9UGP5)
PDBExternal DatabaseDetails
Met 241-initiating methionine
Ala 543Cys 543engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight44112.1
Non-Polymers*Number of molecules5
Total formula weight269.9
All*Total formula weight44382.1
*Water molecules are not included.

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PDB entries from 2025-07-23

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