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1XSP

Crystal Structure of human DNA polymerase lambda in complex with nicked DNA and pyrophosphate

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0006281biological_processDNA repair
A0016779molecular_functionnucleotidyltransferase activity
A0034061molecular_functionDNA polymerase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA A 576
ChainResidue
AASP427
AASP429
APPV579
AHOH608
AHOH686
PDG7

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA A 577
ChainResidue
PDA5
PHOH40
PHOH172
ASER339
AILE341
AALA344

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA A 578
ChainResidue
ASER463
AHOH613
AHOH691
AHOH738
THOH21
THOH44

site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE NA D 503
ChainResidue
ALYS324
DDG1

site_idAC5
Number of Residues11
DetailsBINDING SITE FOR RESIDUE PPV A 579
ChainResidue
AARG386
AGLY416
ASER417
AARG420
AGLY426
AASP429
ANA576
AHOH584
AHOH631
AHOH686
PDG7

Functional Information from PROSITE/UniProt
site_idPS00522
Number of Residues20
DetailsDNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP
ChainResidueDetails
AGLY416-PRO435

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues56
DetailsRegion: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"14992725","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues9
DetailsRegion: {"description":"Involved in primer binding","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsActive site: {"description":"Schiff-base intermediate with DNA","evidences":[{"source":"PubMed","id":"11457865","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1jms
ChainResidueDetails
AASP490

238895

PDB entries from 2025-07-16

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