1RRV

X-ray crystal structure of TDP-vancosaminyltransferase GtfD as a complex with TDP and the natural substrate, desvancosaminyl vancomycin.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	GLYCOSYLTRANSFERASE GTFD	polymer	416	43905.9	2	UniProt (Q9AFC7) Pfam (PF03033) Pfam (PF06722)	AMYCOLATOPSIS ORIENTALIS
2	C, D (C, D)	DESVANCOSAMINYL VANCOMYCIN	polymer	7	1150.0	2	NOR (NOR00681) BIRD (PRD_000205)	AMYCOLATOPSIS ORIENTALIS
3	E, I (A, B)	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
4	F, J (A, B)	THYMIDINE-5'-DIPHOSPHATE	non-polymer		402.2	2	Chemie (TYD)
5	G, H, K (A, B)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
6	L, M (C, D)	beta-D-glucopyranose	non-polymer		180.2	2	BIRD (PRD_000205) Chemie (BGC)
7	N, O, P, Q (A, B, C, D)	water	water		18.0	500	Chemie (HOH)

Sequence modifications

A, B: 1 - 408 (UniProt: Q9AFC7)

PDB	External Database	Details
Leu 195	Cys 195	cloning artifact
Leu 196	Trp 196	cloning artifact
Ala 197	Pro 197	cloning artifact
Leu 409	-	cloning artifact
Glu 410	-	cloning artifact
His 411	-	expression tag
His 412	-	expression tag
His 413	-	expression tag
His 414	-	expression tag
His 415	-	expression tag
His 416	-	expression tag

A, B: 409 - 416 (PDB: 1RRV)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	90111.7
Non-Polymers*	Number of molecules	9
	Total formula weight	1519.2
All*	Total formula weight	91630.9

*Water molecules are not included.