1DGK
MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I WITH GLUCOSE AND ADP IN THE ACTIVE SITE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (N) | HEXOKINASE TYPE I | polymer | 917 | 102557.0 | 1 | UniProt (P19367) Pfam (PF00349) Pfam (PF03727) | Homo sapiens (human) | HK I, BRAIN FORM HEXOKINASE |
| 2 | B, C (N) | alpha-D-glucopyranose | non-polymer | 180.2 | 2 | Chemie (GLC) | |||
| 3 | D (N) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | E, F (N) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 5 | G (N) | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
N: 1 - 917 (UniProt: P19367)
| PDB | External Database | Details |
|---|---|---|
| Glu 240 | Ala 280 | engineered mutation |
| Arg 243 | Ala 283 | engineered mutation |
| Tyr 284 | Gly 284 | engineered mutation |
| Ala 536 | Thr 536 | engineered mutation |
| Asp 730 | Asn 730 | conflict |
| Leu 776 | Met 776 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 102557.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1309.7 | |
| All* | Total formula weight | 103866.7 |
