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1DGK

MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I WITH GLUCOSE AND ADP IN THE ACTIVE SITE

Functional Information from GO Data
ChainGOidnamespacecontents
N0000166molecular_functionnucleotide binding
N0001678biological_processintracellular glucose homeostasis
N0002376biological_processimmune system process
N0002720biological_processpositive regulation of cytokine production involved in immune response
N0003824molecular_functioncatalytic activity
N0004340molecular_functionglucokinase activity
N0004396molecular_functionhexokinase activity
N0005515molecular_functionprotein binding
N0005524molecular_functionATP binding
N0005536molecular_functionglucose binding
N0005737cellular_componentcytoplasm
N0005739cellular_componentmitochondrion
N0005741cellular_componentmitochondrial outer membrane
N0005829cellular_componentcytosol
N0005975biological_processcarbohydrate metabolic process
N0006002biological_processfructose 6-phosphate metabolic process
N0006006biological_processglucose metabolic process
N0006013biological_processmannose metabolic process
N0006096biological_processglycolytic process
N0006954biological_processinflammatory response
N0008152biological_processmetabolic process
N0008865molecular_functionfructokinase activity
N0016020cellular_componentmembrane
N0016301molecular_functionkinase activity
N0016310biological_processphosphorylation
N0016740molecular_functiontransferase activity
N0016773molecular_functionphosphotransferase activity, alcohol group as acceptor
N0019158molecular_functionmannokinase activity
N0019318biological_processhexose metabolic process
N0019637biological_processorganophosphate metabolic process
N0032731biological_processpositive regulation of interleukin-1 beta production
N0042834molecular_functionpeptidoglycan binding
N0045087biological_processinnate immune response
N0045121cellular_componentmembrane raft
N0046835biological_processcarbohydrate phosphorylation
N0047931molecular_functionglucosamine kinase activity
N0051156biological_processglucose 6-phosphate metabolic process
N0061621biological_processcanonical glycolysis
N0072655biological_processestablishment of protein localization to mitochondrion
N0072656biological_processmaintenance of protein location in mitochondrion
N1901135biological_processcarbohydrate derivative metabolic process
Functional Information from PROSITE/UniProt
site_idPS00378
Number of Residues26
DetailsHEXOKINASE_1 Hexokinase domain signature. VGFTFSFPcqqskIDeaiLitWTKrF
ChainResidueDetails
NVAL150-PHE175
NLEU598-PHE623

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1QHA
ChainResidueDetails
NARG30
NARG425

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKC
ChainResidueDetails
NASP84
NTHR863

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1HKC, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA
ChainResidueDetails
NSER155

site_idSWS_FT_FI4
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0000269|PubMed:9735292, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1HKC, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
ChainResidueDetails
NTHR172
NASN208
NASN235
NGLU260
NGLN291

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA
ChainResidueDetails
NASP209

site_idSWS_FT_FI6
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
ChainResidueDetails
NTHR232
NASP413
NSER449
NTHR680
NASP861

site_idSWS_FT_FI7
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:10574795, ECO:0007744|PDB:1QHA
ChainResidueDetails
NASN345

site_idSWS_FT_FI8
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA
ChainResidueDetails
NASP532

site_idSWS_FT_FI9
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
ChainResidueDetails
NSER603

site_idSWS_FT_FI10
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1DGK, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOE, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
ChainResidueDetails
NTHR620
NASN656
NSER682
NGLU708
NGLU742

site_idSWS_FT_FI11
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA
ChainResidueDetails
NASP657

site_idSWS_FT_FI12
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:10686099, ECO:0007744|PDB:1DGK
ChainResidueDetails
NGLY747
NTHR784

site_idSWS_FT_FI13
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:10574795, ECO:0000269|PubMed:10686099, ECO:0000269|PubMed:9493266, ECO:0007744|PDB:1CZA, ECO:0007744|PDB:1HKB, ECO:0007744|PDB:1QHA, ECO:0007744|PDB:4F9O, ECO:0007744|PDB:4FOI, ECO:0007744|PDB:4FPA, ECO:0007744|PDB:4FPB
ChainResidueDetails
NSER897

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:25944712
ChainResidueDetails
NMET1

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P05708
ChainResidueDetails
NSER337

Catalytic Information from CSA
site_idMCSA1
Number of Residues3
DetailsM-CSA 696
ChainResidueDetails
NARG539electrostatic stabiliser, polar interaction
NSER603electrostatic stabiliser, polar interaction
NASP657proton acceptor, proton donor

217705

PDB entries from 2024-03-27

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