1A9X

CARBAMOYL PHOSPHATE SYNTHETASE: CAUGHT IN THE ACT OF GLUTAMINE HYDROLYSIS

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G	CARBAMOYL PHOSPHATE SYNTHETASE (LARGE CHAIN)	polymer	1073	117956.7	4	UniProt (P00968) Pfam (PF02786) Pfam (PF02787) Pfam (PF02142) In PDB	Escherichia coli
2	B, D, F, H	CARBAMOYL PHOSPHATE SYNTHETASE (SMALL CHAIN)	polymer	379	41254.5	4	UniProt (P00907) Pfam (PF00988) Pfam (PF00117) Pfam (PF07722) UniProt (by SIFTS) (P0A6F1) In PDB	Escherichia coli
3	C, E, G, A	PHOSPHATE ION	non-polymer		95.0	15	Chemie (PO4)
4	G, C, E, A	MANGANESE (II) ION	non-polymer		54.9	12	Chemie (MN)
5	A, F, H, B, D...	POTASSIUM ION	non-polymer		39.1	32	Chemie (K)
6	F, H, B, D, G...	CHLORIDE ION	non-polymer		35.5	28	Chemie (CL)
7	E, G, A, C	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	8	Chemie (ADP)
8	E, G, A, C	L-ornithine	non-polymer		132.2	4	Chemie (ORN)
9	E, G, A, C	TETRAETHYLAMMONIUM ION	non-polymer		130.3	4	Chemie (NET)
10		water	water		18.0	4528	Chemie (HOH)

Sequence modifications

A, C, E, G: 2 - 1073 (UniProt: P00968)

PDB	External Database	Details
Asn 46	Leu 45	conflict
Ala 716	Pro 715	conflict

B, D, F, H: 1502 - 1880 (UniProt: P00907)

PDB	External Database	Details
Gln 1683	Glu 183	conflict
Cyg 1769	Cys 269	modified residue
Asn 1853	His 353	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	636844.7
Non-Polymers*	Number of molecules	103
	Total formula weight	8794.9
All*	Total formula weight	645639.6

*Water molecules are not included.