Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1A9X

CARBAMOYL PHOSPHATE SYNTHETASE: CAUGHT IN THE ACT OF GLUTAMINE HYDROLYSIS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
A	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005951	cellular_component	carbamoyl-phosphate synthase complex
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0016597	molecular_function	amino acid binding
A	0016874	molecular_function	ligase activity
A	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B	0004359	molecular_function	glutaminase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005951	cellular_component	carbamoyl-phosphate synthase complex
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006526	biological_process	L-arginine biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0046982	molecular_function	protein heterodimerization activity
C	0000166	molecular_function	nucleotide binding
C	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
C	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005951	cellular_component	carbamoyl-phosphate synthase complex
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006526	biological_process	L-arginine biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0016597	molecular_function	amino acid binding
C	0016874	molecular_function	ligase activity
C	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D	0004359	molecular_function	glutaminase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005951	cellular_component	carbamoyl-phosphate synthase complex
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006526	biological_process	L-arginine biosynthetic process
D	0006541	biological_process	glutamine metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0016874	molecular_function	ligase activity
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0044205	biological_process	'de novo' UMP biosynthetic process
D	0046982	molecular_function	protein heterodimerization activity
E	0000166	molecular_function	nucleotide binding
E	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
E	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005951	cellular_component	carbamoyl-phosphate synthase complex
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006526	biological_process	L-arginine biosynthetic process
E	0006541	biological_process	glutamine metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0016597	molecular_function	amino acid binding
E	0016874	molecular_function	ligase activity
E	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0044205	biological_process	'de novo' UMP biosynthetic process
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F	0004359	molecular_function	glutaminase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005951	cellular_component	carbamoyl-phosphate synthase complex
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006526	biological_process	L-arginine biosynthetic process
F	0006541	biological_process	glutamine metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0016874	molecular_function	ligase activity
F	0019856	biological_process	pyrimidine nucleobase biosynthetic process
F	0044205	biological_process	'de novo' UMP biosynthetic process
F	0046982	molecular_function	protein heterodimerization activity
G	0000166	molecular_function	nucleotide binding
G	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
G	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005951	cellular_component	carbamoyl-phosphate synthase complex
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006526	biological_process	L-arginine biosynthetic process
G	0006541	biological_process	glutamine metabolic process
G	0008652	biological_process	amino acid biosynthetic process
G	0016597	molecular_function	amino acid binding
G	0016874	molecular_function	ligase activity
G	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
G	0019856	biological_process	pyrimidine nucleobase biosynthetic process
G	0044205	biological_process	'de novo' UMP biosynthetic process
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H	0004359	molecular_function	glutaminase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005951	cellular_component	carbamoyl-phosphate synthase complex
H	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006526	biological_process	L-arginine biosynthetic process
H	0006541	biological_process	glutamine metabolic process
H	0008652	biological_process	amino acid biosynthetic process
H	0016874	molecular_function	ligase activity
H	0019856	biological_process	pyrimidine nucleobase biosynthetic process
H	0044205	biological_process	'de novo' UMP biosynthetic process
H	0046982	molecular_function	protein heterodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN G 7901

Chain	Residue
G	HOH851
G	MET6174
G	GLU6299
G	ASN6301
G	ADP7900
G	PO47906

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN G 7902

Chain	Residue
G	HOH874
G	GLN6285
G	GLU6299
G	ADP7900
G	PO47906

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 7903

Chain	Residue
G	GLU6215
G	ASN6236
G	ASP6238
G	ALA6239
G	ILE6242
G	SER6247

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K G 7904

Chain	Residue
G	HOH96
G	HOH851
G	ALA6126
G	GLU6127
G	GLU6299
G	MET6300
G	ASN6301

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 G 7906

Chain	Residue
G	HOH32
G	HOH874
G	MET6174
G	GLY6175
G	HIS6243
G	GLN6285
G	GLU6299
G	ASN6301
G	ARG6303
G	ARG6306
G	ADP7900
G	MN7901
G	MN7902
G	K7942

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN G 7911

Chain	Residue
G	GLN6829
G	GLU6841
G	ADP7910

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K G 7912

Chain	Residue
G	GLU6841
G	ASN6843
G	ADP7910

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 7913

Chain	Residue
G	GLU6761
G	HIS6781
G	GLU6783
G	GLN6784
G	VAL6787
G	SER6792

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL G 7930

Chain	Residue
G	HOH64
G	GLN6093
G	THR6173
G	MET6174

site_id	AD1
Number of Residues	11
Details	ADP BINDING SITE.

Chain	Residue
A	ARG129
A	GLN285
A	GLU299
A	ARG169
A	GLY176
A	GLU208
A	LEU210
A	GLU215
A	GLY241
A	ILE242
A	HIS243

site_id	AD2
Number of Residues	8
Details	ADP BINDING SITE.

Chain	Residue
A	ARG715
A	HIS754
A	LEU756
A	GLU761
A	GLY786
A	VAL787
A	HIS788
A	GLU841

site_id	AD3
Number of Residues	11
Details	ADP BINDING SITE.

Chain	Residue
C	ARG2129
C	ARG2169
C	GLY2176
C	GLU2208
C	LEU2210
C	GLU2215
C	GLY2241
C	ILE2242
C	HIS2243
C	GLN2285
C	GLU2299

site_id	AD4
Number of Residues	8
Details	ADP BINDING SITE.

Chain	Residue
C	ARG2715
C	HIS2754
C	LEU2756
C	GLU2761
C	GLY2786
C	VAL2787
C	HIS2788
C	GLU2841

site_id	AD5
Number of Residues	11
Details	ADP BINDING SITE.

Chain	Residue
E	ARG4129
E	ARG4169
E	GLY4176
E	GLU4208
E	LEU4210
E	GLU4215
E	GLY4241
E	ILE4242
E	HIS4243
E	GLN4285
E	GLU4299

site_id	AD6
Number of Residues	8
Details	ADP BINDING SITE.

Chain	Residue
E	ARG4715
E	HIS4754
E	LEU4756
E	GLU4761
E	GLY4786
E	VAL4787
E	HIS4788
E	GLU4841

site_id	AD7
Number of Residues	11
Details	ADP BINDING SITE.

Chain	Residue
G	GLN6285
G	GLU6299
G	ARG6129
G	ARG6169
G	GLY6176
G	GLU6208
G	LEU6210
G	GLU6215
G	GLY6241
G	ILE6242
G	HIS6243

site_id	AD8
Number of Residues	8
Details	ADP BINDING SITE.

Chain	Residue
G	ARG6715
G	HIS6754
G	LEU6756
G	GLU6761
G	GLY6786
G	VAL6787
G	HIS6788
G	GLU6841

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 7931

Chain	Residue
G	ASN6289
G	ASN6292
G	ARG6294

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL G 7932

Chain	Residue
G	HOH261
G	ALA6370
G	ASN6371
G	PHE6900
G	PRO6901
G	GLY6902

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL H 7933

Chain	Residue
H	PHE7515
H	ASP7614

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 7934

Chain	Residue
G	ARG6845
G	ALA6847
G	ARG6848

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G 7935

Chain	Residue
G	HOH645
G	TRP6071

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G 7936

Chain	Residue
G	LYS6475
G	ASN6485

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K G 7940

Chain	Residue
G	HOH835
G	ASP6084
G	GLY6112
G	THR6114

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K H 7941

Chain	Residue
H	HOH468
H	HIS7516
H	ASP7612

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K G 7942

Chain	Residue
G	HOH143
G	GLU6217
G	THR6244
G	ASN6283
G	GLN6285
G	SER6307
G	PO47906

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K G 7943

Chain	Residue
G	HOH677
G	HOH678
G	THR6143
G	ALA6144

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 A 1981

Chain	Residue
A	ALA798
A	LEU801

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 A 1982

Chain	Residue
A	GLU560
A	ASP592
A	GLY593

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 3901

Chain	Residue
C	GLU2299
C	ASN2301
C	ADP3900
C	K3904
C	PO43906
C	HOH4447

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN C 3902

Chain	Residue
C	GLN2285
C	GLU2299
C	ADP3900
C	PO43906
C	HOH4661

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 3903

Chain	Residue
C	GLU2215
C	ASN2236
C	ASP2238
C	ALA2239
C	ILE2242
C	SER2247

site_id	CC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K C 3904

Chain	Residue
C	ALA2126
C	GLU2127
C	GLU2299
C	MET2300
C	ASN2301
C	MN3901
C	HOH4079
C	HOH4632

site_id	CC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 C 3906

Chain	Residue
C	MET2174
C	GLY2175
C	HIS2243
C	GLN2285
C	GLU2299
C	ASN2301
C	ARG2303
C	ARG2306
C	ADP3900
C	MN3901
C	MN3902
C	K3942
C	HOH4015
C	HOH4122

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN C 3911

Chain	Residue
C	GLN2829
C	GLU2841
C	ADP3910
C	HOH4825

site_id	CY1
Number of Residues	6
Details	BINDING SITE FOR GLUTAMYL THIOESTERMEDIATE IN SMALL SUBUNIT.

Chain	Residue
B	SER1547
B	GLY1741
B	GLY1743
B	GLN1773
B	GLY1813
B	PHE1814

site_id	CY2
Number of Residues	6
Details	BINDING SITE FOR GLUTAMYL THIOESTERMEDIATE IN SMALL SUBUNIT.

Chain	Residue
D	SER3547
D	GLY3741
D	GLY3743
D	GLN3773
D	GLY3813
D	PHE3814

site_id	CY3
Number of Residues	6
Details	BINDING SITE FOR GLUTAMYL THIOESTERMEDIATE IN SMALL SUBUNIT.

Chain	Residue
F	SER5547
F	GLY5741
F	GLY5743
F	GLN5773
F	GLY5813
F	PHE5814

site_id	CY4
Number of Residues	6
Details	BINDING SITE FOR GLUTAMYL THIOESTERMEDIATE IN SMALL SUBUNIT.

Chain	Residue
H	SER7547
H	GLY7741
H	GLY7743
H	GLN7773
H	GLY7813
H	PHE7814

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K C 3912

Chain	Residue
C	GLU2841
C	ASN2843
C	ADP3910

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 3913

Chain	Residue
C	GLU2761
C	HIS2781
C	GLU2783
C	GLN2784
C	VAL2787
C	SER2792

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 3930

Chain	Residue
C	THR2173
C	MET2174
C	HOH4012

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 3931

Chain	Residue
C	ASN2289
C	ASN2292
C	ARG2294

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 3932

Chain	Residue
C	ALA2370
C	ASN2371
C	PHE2900
C	PRO2901
C	GLY2902

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 3933

Chain	Residue
C	HOH4414
D	PHE3515
D	ASP3614
D	HOH3973

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 3934

Chain	Residue
C	PHE2578
C	ARG2845
C	ALA2847
C	ARG2848

site_id	DC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 3935

Chain	Residue
C	HIS2070
C	TRP2071

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 3936

Chain	Residue
C	LYS2475
C	ASN2485

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K C 3940

Chain	Residue
C	ASP2084
C	GLY2112
C	THR2114

site_id	EC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K D 3941

Chain	Residue
D	HIS3516
D	ASP3612
D	HOH3986

site_id	EC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 3942

Chain	Residue
C	GLU2217
C	THR2244
C	ASN2283
C	GLN2285
C	PO43906
C	HOH4122

site_id	EC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K C 3943

Chain	Residue
C	THR2143
C	ALA2144
C	HOH4473
C	HOH4474
C	HOH4648

site_id	EC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 C 3980

Chain	Residue
C	ASP2518
C	GLN2519

site_id	EC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 C 3981

Chain	Residue
C	ASP2592
C	GLY2593

site_id	EC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 C 3982

Chain	Residue
C	LEU2801
C	HOH4827
C	HOH4828

site_id	EC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 5901

Chain	Residue
E	GLU4299
E	ASN4301
E	ADP5900
E	MN5902
E	PO45906
E	HOH6698

site_id	EC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN E 5902

Chain	Residue
E	GLN4285
E	GLU4299
E	ADP5900
E	MN5901
E	PO45906
E	K5942
E	HOH6707

site_id	FC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 5903

Chain	Residue
E	GLU4215
E	ASN4236
E	ASP4238
E	ALA4239
E	ILE4242
E	SER4247

site_id	FC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K E 5904

Chain	Residue
E	ALA4126
E	GLU4127
E	GLU4299
E	MET4300
E	ASN4301
E	HOH6083
E	HOH6698

site_id	FC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 E 5906

Chain	Residue
E	MET4174
E	GLY4175
E	HIS4243
E	GLN4285
E	GLU4299
E	ASN4301
E	ARG4303
E	ARG4306
E	ADP5900
E	MN5901
E	MN5902
E	K5942
E	HOH6018
E	HOH6128

site_id	FC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN E 5911

Chain	Residue
E	GLN4829
E	GLU4841
E	ADP5910

site_id	FC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K E 5912

Chain	Residue
E	GLU4841
E	ASN4843
E	ADP5910

site_id	FC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 5913

Chain	Residue
E	GLU4761
E	HIS4781
E	GLU4783
E	GLN4784
E	VAL4787
E	SER4792

site_id	FC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL E 5930

Chain	Residue
E	GLN4093
E	THR4173
E	MET4174
E	HOH6013
E	HOH6051

site_id	FC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 5931

Chain	Residue
E	ASN4289
E	ASN4292
E	ARG4294

site_id	FC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E 5932

Chain	Residue
E	ALA4370
E	ASN4371
E	PRO4901
E	GLY4902

site_id	GC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL F 5933

Chain	Residue
F	PHE5515
F	ILE5613
F	ASP5614

site_id	GC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E 5934

Chain	Residue
E	PHE4578
E	ALA4847
E	ARG4848
E	HOH6824

site_id	GC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 5935

Chain	Residue
E	TRP4071

site_id	GC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 5936

Chain	Residue
E	LYS4475
E	ASN4485
E	HOH6286

site_id	GC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K E 5940

Chain	Residue
E	ASP4084
E	GLY4112
E	THR4114
E	HOH6431

site_id	GC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K F 5941

Chain	Residue
E	HOH6419
F	HOH2588
F	HIS5516
F	ASP5612

site_id	GC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K E 5942

Chain	Residue
E	GLU4217
E	THR4244
E	ASN4283
E	GLN4285
E	MN5902
E	PO45906
E	HOH6128

site_id	GC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K E 5943

Chain	Residue
E	THR4143
E	ALA4144
E	HOH6483
E	HOH6484
E	HOH6485

site_id	GC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 E 5980

Chain	Residue
E	TYR4799
E	THR4800
E	LEU4801

site_id	HC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PO4 E 5981

Chain	Residue
E	GLU4560

site_id	HC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 G 7980

Chain	Residue
G	LYS6475
G	GLN6491

site_id	HC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 G 7981

Chain	Residue
G	ALA6798
G	TYR6799
G	THR6800
G	LEU6801

site_id	HC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 G 7982

Chain	Residue
G	ASP6592
G	GLY6593

site_id	HC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 1901

Chain	Residue
A	GLU299
A	ASN301
A	ADP1900
A	PO41906
A	HOH2674

site_id	HC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN A 1902

Chain	Residue
A	GLN285
A	GLU299
A	ADP1900
A	PO41906

site_id	HC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 1903

Chain	Residue
A	GLU215
A	ASN236
A	ASP238
A	ALA239
A	ILE242
A	SER247

site_id	HC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 1904

Chain	Residue
A	ALA126
A	GLU127
A	GLU299
A	MET300
A	ASN301
A	HOH2674

site_id	HC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PO4 A 1906

Chain	Residue
A	MET174
A	GLY175
A	HIS243
A	GLN285
A	GLU299
A	ASN301
A	ARG303
A	ARG306
A	ADP1900
A	MN1901
A	MN1902
A	K1942
A	HOH2124

site_id	IC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN A 1911

Chain	Residue
A	GLN829
A	GLU841
A	ADP1910

site_id	IC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K A 1912

Chain	Residue
A	GLU841
A	ASN843
A	ADP1910

site_id	IC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 1913

Chain	Residue
A	GLU761
A	HIS781
A	GLU783
A	GLN784
A	VAL787
A	SER792

site_id	IC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 1930

Chain	Residue
A	GLN93
A	THR173
A	MET174
A	HOH2013
A	HOH2049

site_id	IC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1931

Chain	Residue
A	ASN289
A	ASN292
A	ARG294

site_id	IC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 1932

Chain	Residue
A	ALA370
A	ASN371
A	PHE900
A	PRO901
A	GLY902

site_id	IC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 1933

Chain	Residue
B	ASP1614
B	HOH1972

site_id	IC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1934

Chain	Residue
A	PHE578
A	ARG845
A	ALA847
A	ARG848

site_id	IC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1935

Chain	Residue
A	TRP71

site_id	JC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 1936

Chain	Residue
A	LYS475
A	ASN485
A	PHE488
A	HOH2284
A	HOH2747

site_id	JC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 1940

Chain	Residue
A	ASP84
A	GLY112
A	THR114
A	HOH2426
A	HOH2628

site_id	JC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K B 1941

Chain	Residue
B	HIS1516
B	ASP1612
B	HOH1984

site_id	JC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K A 1942

Chain	Residue
A	GLU217
A	THR244
A	ASN283
A	GLN285
A	SER307
A	PO41906
A	HOH2124

site_id	JC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K A 1943

Chain	Residue
A	THR143
A	ALA144
A	HOH2478

site_id	JC6
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ADP G 7900

Chain	Residue
G	HOH141
G	HOH874
G	ARG6129
G	ILE6167
G	ARG6169
G	THR6173
G	MET6174
G	GLY6175
G	GLY6176
G	GLU6208
G	LEU6210
G	GLU6215
G	MET6240
G	GLY6241
G	ILE6242
G	HIS6243
G	THR6244
G	GLN6285
G	GLU6299
G	THR6376
G	MN7901
G	MN7902
G	PO47906

site_id	JC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP G 7910

Chain	Residue
G	HOH763
G	PRO6690
G	ARG6715
G	MET6725
G	HIS6754
G	PHE6755
G	LEU6756
G	GLU6761
G	ALA6785
G	GLY6786
G	VAL6787
G	HIS6788
G	SER6789
G	GLN6829
G	GLU6841
G	MN7911
G	K7912

site_id	JC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ORN G 7920

Chain	Residue
G	HOH85
G	HOH418
G	HOH903
G	GLU6783
G	ASP6791
G	GLU6892
G	VAL6893
G	LEU6907
G	TYR7040
G	ASP7041
G	THR7042

site_id	JC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NET G 7950

Chain	Residue
G	GLN6022
G	GLN6093
G	THR6094
G	ASN6097

site_id	KC1
Number of Residues	28
Details	BINDING SITE FOR RESIDUE ADP C 3900

Chain	Residue
C	ARG2129
C	ILE2167
C	ARG2169
C	THR2173
C	MET2174
C	GLY2175
C	GLY2176
C	GLU2208
C	SER2209
C	LEU2210
C	ILE2211
C	GLU2215
C	MET2240
C	GLY2241
C	ILE2242
C	HIS2243
C	THR2244
C	GLN2285
C	ILE2298
C	GLU2299
C	THR2376
C	MN3901
C	MN3902
C	PO43906
C	HOH4120
C	HOH4447
C	HOH4633
C	HOH4661

site_id	KC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP C 3910

Chain	Residue
C	PRO2690
C	ARG2715
C	MET2725
C	HIS2754
C	PHE2755
C	LEU2756
C	GLU2761
C	ALA2785
C	GLY2786
C	VAL2787
C	HIS2788
C	SER2789
C	GLN2829
C	GLU2841
C	MN3911
C	K3912

site_id	KC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ORN C 3920

Chain	Residue
C	GLU2783
C	ASP2791
C	ALA2793
C	GLU2892
C	VAL2893
C	LEU2907
C	TYR3040
C	ASP3041
C	THR3042
C	HOH4066
C	HOH4068
C	HOH4365

site_id	KC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NET C 3950

Chain	Residue
C	THR2094
C	ASN2097
C	ASN2936
C	HOH4001

site_id	KC5
Number of Residues	24
Details	BINDING SITE FOR RESIDUE ADP E 5900

Chain	Residue
E	ARG4129
E	ILE4167
E	ARG4169
E	MET4174
E	GLY4175
E	GLY4176
E	GLU4208
E	LEU4210
E	ILE4211
E	GLU4215
E	MET4240
E	GLY4241
E	ILE4242
E	HIS4243
E	THR4244
E	GLN4285
E	ILE4298
E	GLU4299
E	THR4376
E	MN5901
E	MN5902
E	PO45906
E	HOH6126
E	HOH6707

site_id	KC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ADP E 5910

Chain	Residue
E	PRO4690
E	VAL4713
E	ARG4715
E	MET4725
E	HIS4754
E	PHE4755
E	LEU4756
E	GLU4761
E	ALA4785
E	GLY4786
E	VAL4787
E	HIS4788
E	SER4789
E	GLN4829
E	GLU4841
E	PRO4909
E	MN5911
E	K5912
E	HOH6798

site_id	KC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ORN E 5920

Chain	Residue
E	GLU4783
E	ASP4791
E	GLU4892
E	VAL4893
E	LEU4907
E	TYR5040
E	ASP5041
E	THR5042
E	HOH6070
E	HOH6072
E	HOH6370

site_id	KC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NET E 5950

Chain	Residue
E	GLN4022
E	THR4094
E	ASN4097
E	HOH6004

site_id	KC9
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ADP A 1900

Chain	Residue
A	ARG129
A	ILE167
A	ARG169
A	MET174
A	GLY175
A	GLY176
A	GLU208
A	LEU210
A	GLU215
A	MET240
A	GLY241
A	ILE242
A	HIS243
A	THR244
A	GLN285
A	GLU299
A	THR376
A	MN1901
A	MN1902
A	PO41906
A	HOH2672

site_id	LC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP A 1910

Chain	Residue
A	PRO690
A	ARG715
A	MET725
A	HIS754
A	PHE755
A	LEU756
A	GLU761
A	ALA785
A	GLY786
A	VAL787
A	HIS788
A	SER789
A	GLN829
A	GLU841
A	MN1911
A	K1912
A	HOH2561
A	HOH2810
A	HOH2845
A	HOH2846

site_id	LC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN A 1920

Chain	Residue
A	GLU783
A	ASP791
A	ALA793
A	GLU892
A	LEU907
A	TYR1040
A	ASP1041
A	THR1042
A	HOH2070
A	HOH2370

site_id	LC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NET A 1950

Chain	Residue
A	GLN22
A	THR94

site_id	OR1
Number of Residues	5
Details	ORNITHINE BINDING SITE.

Chain	Residue
A	ASP791
A	GLU783
A	GLU892
A	TYR1040
A	THR1042

site_id	OR2
Number of Residues	5
Details	ORNITHINE BINDING SITE.

Chain	Residue
C	ASP2791
C	GLU2783
C	GLU2892
C	TYR3040
C	THR3042

site_id	OR3
Number of Residues	5
Details	ORNITHINE BINDING SITE.

Chain	Residue
E	ASP4791
E	GLU4783
E	GLU4892
E	TYR5040
E	THR5042

site_id	OR4
Number of Residues	5
Details	ORNITHINE BINDING SITE.

Chain	Residue
G	ASP6791
G	GLU6783
G	GLU6892
G	TYR7040
G	THR7042

Functional Information from PROSITE/UniProt

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. FPCIIRPSftmGGsG

Chain	Residue	Details
A	PHE164-GLY178
A	TYR710-ALA724

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. VIEMNPRV

Chain	Residue	Details
A	VAL297-VAL304
A	LEU839-ALA846

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	780
Details	Domain: {"description":"ATP-grasp 1","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	544
Details	Domain: {"description":"MGS-like","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1604
Details	Region: {"description":"Carboxyphosphate synthetic domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	596
Details	Region: {"description":"Oligomerization domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	544
Details	Region: {"description":"Allosteric domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C30","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C3O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KEE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T36","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10587438","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	8
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10587438","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
B	LEU1770	covalent catalysis, proton shuttle (general acid/base)
A	ARG303	electrostatic stabiliser
A	ARG715	electrostatic stabiliser
A	GLU761	steric role
A	GLN829	metal ligand
A	GLU841	metal ligand
A	ASN843	metal ligand
A	ARG848	electrostatic stabiliser
B	SER1857	proton shuttle (general acid/base)
B	GLY1859	steric role
A	GLU215	steric role
A	HIS243	proton shuttle (general acid/base)
A	ASN283	electrostatic stabiliser
A	GLN285	metal ligand
A	GLU299	metal ligand
A	ASN301	metal ligand

site_id	MCSA2
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
D	LEU3770	covalent catalysis, proton shuttle (general acid/base)
C	ARG2303	electrostatic stabiliser
C	ARG2715	electrostatic stabiliser
C	GLU2761	steric role
C	GLN2829	metal ligand
C	GLU2841	metal ligand
C	ASN2843	metal ligand
C	ARG2848	electrostatic stabiliser
D	SER3857	proton shuttle (general acid/base)
D	GLY3859	steric role
C	GLU2215	steric role
C	HIS2243	proton shuttle (general acid/base)
C	ASN2283	electrostatic stabiliser
C	GLN2285	metal ligand
C	GLU2299	metal ligand
C	ASN2301	metal ligand

site_id	MCSA3
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
F	LEU5770	covalent catalysis, proton shuttle (general acid/base)
E	ARG4303	electrostatic stabiliser
E	ARG4715	electrostatic stabiliser
E	GLU4761	steric role
E	GLN4829	metal ligand
E	GLU4841	metal ligand
E	ASN4843	metal ligand
E	ARG4848	electrostatic stabiliser
F	SER5857	proton shuttle (general acid/base)
F	GLY5859	steric role
E	GLU4215	steric role
E	HIS4243	proton shuttle (general acid/base)
E	ASN4283	electrostatic stabiliser
E	GLN4285	metal ligand
E	GLU4299	metal ligand
E	ASN4301	metal ligand

site_id	MCSA4
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
H	LEU7770	covalent catalysis, proton shuttle (general acid/base)
G	ARG6303	electrostatic stabiliser
G	ARG6715	electrostatic stabiliser
G	GLU6761	steric role
G	GLN6829	metal ligand
G	GLU6841	metal ligand
G	ASN6843	metal ligand
G	ARG6848	electrostatic stabiliser
H	SER7857	proton shuttle (general acid/base)
H	GLY7859	steric role
G	GLU6215	steric role
G	HIS6243	proton shuttle (general acid/base)
G	ASN6283	electrostatic stabiliser
G	GLN6285	metal ligand
G	GLU6299	metal ligand
G	ASN6301	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)