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1A9X

CARBAMOYL PHOSPHATE SYNTHETASE: CAUGHT IN THE ACT OF GLUTAMINE HYDROLYSIS

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004070molecular_functionaspartate carbamoyltransferase activity
A0004087molecular_functioncarbamoyl-phosphate synthase (ammonia) activity
A0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A0004151molecular_functiondihydroorotase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005951cellular_componentcarbamoyl-phosphate synthase complex
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006221biological_processpyrimidine nucleotide biosynthetic process
A0006228biological_processUTP biosynthetic process
A0006526biological_processarginine biosynthetic process
A0006541biological_processglutamine metabolic process
A0006807biological_processnitrogen compound metabolic process
A0008652biological_processamino acid biosynthetic process
A0016597molecular_functionamino acid binding
A0016874molecular_functionligase activity
A0019240biological_processcitrulline biosynthetic process
A0019856biological_processpyrimidine nucleobase biosynthetic process
A0044205biological_process'de novo' UMP biosynthetic process
A0046872molecular_functionmetal ion binding
B0000166molecular_functionnucleotide binding
B0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B0004359molecular_functionglutaminase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005951cellular_componentcarbamoyl-phosphate synthase complex
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006221biological_processpyrimidine nucleotide biosynthetic process
B0006526biological_processarginine biosynthetic process
B0006541biological_processglutamine metabolic process
B0008652biological_processamino acid biosynthetic process
B0016874molecular_functionligase activity
B0019856biological_processpyrimidine nucleobase biosynthetic process
B0044205biological_process'de novo' UMP biosynthetic process
B0046982molecular_functionprotein heterodimerization activity
C0000166molecular_functionnucleotide binding
C0004070molecular_functionaspartate carbamoyltransferase activity
C0004087molecular_functioncarbamoyl-phosphate synthase (ammonia) activity
C0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0004151molecular_functiondihydroorotase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005951cellular_componentcarbamoyl-phosphate synthase complex
C0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
C0006221biological_processpyrimidine nucleotide biosynthetic process
C0006228biological_processUTP biosynthetic process
C0006526biological_processarginine biosynthetic process
C0006541biological_processglutamine metabolic process
C0006807biological_processnitrogen compound metabolic process
C0008652biological_processamino acid biosynthetic process
C0016597molecular_functionamino acid binding
C0016874molecular_functionligase activity
C0019240biological_processcitrulline biosynthetic process
C0019856biological_processpyrimidine nucleobase biosynthetic process
C0044205biological_process'de novo' UMP biosynthetic process
C0046872molecular_functionmetal ion binding
D0000166molecular_functionnucleotide binding
D0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0004359molecular_functionglutaminase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005951cellular_componentcarbamoyl-phosphate synthase complex
D0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
D0006221biological_processpyrimidine nucleotide biosynthetic process
D0006526biological_processarginine biosynthetic process
D0006541biological_processglutamine metabolic process
D0008652biological_processamino acid biosynthetic process
D0016874molecular_functionligase activity
D0019856biological_processpyrimidine nucleobase biosynthetic process
D0044205biological_process'de novo' UMP biosynthetic process
D0046982molecular_functionprotein heterodimerization activity
E0000166molecular_functionnucleotide binding
E0004070molecular_functionaspartate carbamoyltransferase activity
E0004087molecular_functioncarbamoyl-phosphate synthase (ammonia) activity
E0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E0004151molecular_functiondihydroorotase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005951cellular_componentcarbamoyl-phosphate synthase complex
E0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
E0006221biological_processpyrimidine nucleotide biosynthetic process
E0006228biological_processUTP biosynthetic process
E0006526biological_processarginine biosynthetic process
E0006541biological_processglutamine metabolic process
E0006807biological_processnitrogen compound metabolic process
E0008652biological_processamino acid biosynthetic process
E0016597molecular_functionamino acid binding
E0016874molecular_functionligase activity
E0019240biological_processcitrulline biosynthetic process
E0019856biological_processpyrimidine nucleobase biosynthetic process
E0044205biological_process'de novo' UMP biosynthetic process
E0046872molecular_functionmetal ion binding
F0000166molecular_functionnucleotide binding
F0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0004359molecular_functionglutaminase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005951cellular_componentcarbamoyl-phosphate synthase complex
F0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
F0006221biological_processpyrimidine nucleotide biosynthetic process
F0006526biological_processarginine biosynthetic process
F0006541biological_processglutamine metabolic process
F0008652biological_processamino acid biosynthetic process
F0016874molecular_functionligase activity
F0019856biological_processpyrimidine nucleobase biosynthetic process
F0044205biological_process'de novo' UMP biosynthetic process
F0046982molecular_functionprotein heterodimerization activity
G0000166molecular_functionnucleotide binding
G0004070molecular_functionaspartate carbamoyltransferase activity
G0004087molecular_functioncarbamoyl-phosphate synthase (ammonia) activity
G0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G0004151molecular_functiondihydroorotase activity
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005951cellular_componentcarbamoyl-phosphate synthase complex
G0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
G0006221biological_processpyrimidine nucleotide biosynthetic process
G0006228biological_processUTP biosynthetic process
G0006526biological_processarginine biosynthetic process
G0006541biological_processglutamine metabolic process
G0006807biological_processnitrogen compound metabolic process
G0008652biological_processamino acid biosynthetic process
G0016597molecular_functionamino acid binding
G0016874molecular_functionligase activity
G0019240biological_processcitrulline biosynthetic process
G0019856biological_processpyrimidine nucleobase biosynthetic process
G0044205biological_process'de novo' UMP biosynthetic process
G0046872molecular_functionmetal ion binding
H0000166molecular_functionnucleotide binding
H0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H0004359molecular_functionglutaminase activity
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005951cellular_componentcarbamoyl-phosphate synthase complex
H0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
H0006221biological_processpyrimidine nucleotide biosynthetic process
H0006526biological_processarginine biosynthetic process
H0006541biological_processglutamine metabolic process
H0008652biological_processamino acid biosynthetic process
H0016874molecular_functionligase activity
H0019856biological_processpyrimidine nucleobase biosynthetic process
H0044205biological_process'de novo' UMP biosynthetic process
H0046982molecular_functionprotein heterodimerization activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN G 7901
ChainResidue
GHOH851
GMET6174
GGLU6299
GASN6301
GADP7900
GPO47906

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN G 7902
ChainResidue
GHOH874
GGLN6285
GGLU6299
GADP7900
GPO47906

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K G 7903
ChainResidue
GGLU6215
GASN6236
GASP6238
GALA6239
GILE6242
GSER6247

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE K G 7904
ChainResidue
GHOH96
GHOH851
GALA6126
GGLU6127
GGLU6299
GMET6300
GASN6301

site_idAC5
Number of Residues14
DetailsBINDING SITE FOR RESIDUE PO4 G 7906
ChainResidue
GHOH32
GHOH874
GMET6174
GGLY6175
GHIS6243
GGLN6285
GGLU6299
GASN6301
GARG6303
GARG6306
GADP7900
GMN7901
GMN7902
GK7942

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MN G 7911
ChainResidue
GGLN6829
GGLU6841
GADP7910

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K G 7912
ChainResidue
GGLU6841
GASN6843
GADP7910

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K G 7913
ChainResidue
GGLU6761
GHIS6781
GGLU6783
GGLN6784
GVAL6787
GSER6792

site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL G 7930
ChainResidue
GHOH64
GGLN6093
GTHR6173
GMET6174

site_idAD1
Number of Residues11
DetailsADP BINDING SITE.
ChainResidue
AARG129
AGLN285
AGLU299
AARG169
AGLY176
AGLU208
ALEU210
AGLU215
AGLY241
AILE242
AHIS243

site_idAD2
Number of Residues8
DetailsADP BINDING SITE.
ChainResidue
AARG715
AHIS754
ALEU756
AGLU761
AGLY786
AVAL787
AHIS788
AGLU841

site_idAD3
Number of Residues11
DetailsADP BINDING SITE.
ChainResidue
CARG2129
CARG2169
CGLY2176
CGLU2208
CLEU2210
CGLU2215
CGLY2241
CILE2242
CHIS2243
CGLN2285
CGLU2299

site_idAD4
Number of Residues8
DetailsADP BINDING SITE.
ChainResidue
CARG2715
CHIS2754
CLEU2756
CGLU2761
CGLY2786
CVAL2787
CHIS2788
CGLU2841

site_idAD5
Number of Residues11
DetailsADP BINDING SITE.
ChainResidue
EARG4129
EARG4169
EGLY4176
EGLU4208
ELEU4210
EGLU4215
EGLY4241
EILE4242
EHIS4243
EGLN4285
EGLU4299

site_idAD6
Number of Residues8
DetailsADP BINDING SITE.
ChainResidue
EARG4715
EHIS4754
ELEU4756
EGLU4761
EGLY4786
EVAL4787
EHIS4788
EGLU4841

site_idAD7
Number of Residues11
DetailsADP BINDING SITE.
ChainResidue
GGLN6285
GGLU6299
GARG6129
GARG6169
GGLY6176
GGLU6208
GLEU6210
GGLU6215
GGLY6241
GILE6242
GHIS6243

site_idAD8
Number of Residues8
DetailsADP BINDING SITE.
ChainResidue
GARG6715
GHIS6754
GLEU6756
GGLU6761
GGLY6786
GVAL6787
GHIS6788
GGLU6841

site_idBC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL G 7931
ChainResidue
GASN6289
GASN6292
GARG6294

site_idBC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CL G 7932
ChainResidue
GHOH261
GALA6370
GASN6371
GPHE6900
GPRO6901
GGLY6902

site_idBC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL H 7933
ChainResidue
HPHE7515
HASP7614

site_idBC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL G 7934
ChainResidue
GARG6845
GALA6847
GARG6848

site_idBC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL G 7935
ChainResidue
GHOH645
GTRP6071

site_idBC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL G 7936
ChainResidue
GLYS6475
GASN6485

site_idBC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE K G 7940
ChainResidue
GHOH835
GASP6084
GGLY6112
GTHR6114

site_idBC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K H 7941
ChainResidue
HHOH468
HHIS7516
HASP7612

site_idBC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE K G 7942
ChainResidue
GHOH143
GGLU6217
GTHR6244
GASN6283
GGLN6285
GSER6307
GPO47906

site_idCC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE K G 7943
ChainResidue
GHOH677
GHOH678
GTHR6143
GALA6144

site_idCC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PO4 A 1981
ChainResidue
AALA798
ALEU801

site_idCC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PO4 A 1982
ChainResidue
AGLU560
AASP592
AGLY593

site_idCC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN C 3901
ChainResidue
CGLU2299
CASN2301
CADP3900
CK3904
CPO43906
CHOH4447

site_idCC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN C 3902
ChainResidue
CGLN2285
CGLU2299
CADP3900
CPO43906
CHOH4661

site_idCC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K C 3903
ChainResidue
CGLU2215
CASN2236
CASP2238
CALA2239
CILE2242
CSER2247

site_idCC7
Number of Residues8
DetailsBINDING SITE FOR RESIDUE K C 3904
ChainResidue
CALA2126
CGLU2127
CGLU2299
CMET2300
CASN2301
CMN3901
CHOH4079
CHOH4632

site_idCC8
Number of Residues14
DetailsBINDING SITE FOR RESIDUE PO4 C 3906
ChainResidue
CMET2174
CGLY2175
CHIS2243
CGLN2285
CGLU2299
CASN2301
CARG2303
CARG2306
CADP3900
CMN3901
CMN3902
CK3942
CHOH4015
CHOH4122

site_idCC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MN C 3911
ChainResidue
CGLN2829
CGLU2841
CADP3910
CHOH4825

site_idCY1
Number of Residues6
DetailsBINDING SITE FOR GLUTAMYL THIOESTERMEDIATE IN SMALL SUBUNIT.
ChainResidue
BSER1547
BGLY1741
BGLY1743
BGLN1773
BGLY1813
BPHE1814

site_idCY2
Number of Residues6
DetailsBINDING SITE FOR GLUTAMYL THIOESTERMEDIATE IN SMALL SUBUNIT.
ChainResidue
DSER3547
DGLY3741
DGLY3743
DGLN3773
DGLY3813
DPHE3814

site_idCY3
Number of Residues6
DetailsBINDING SITE FOR GLUTAMYL THIOESTERMEDIATE IN SMALL SUBUNIT.
ChainResidue
FSER5547
FGLY5741
FGLY5743
FGLN5773
FGLY5813
FPHE5814

site_idCY4
Number of Residues6
DetailsBINDING SITE FOR GLUTAMYL THIOESTERMEDIATE IN SMALL SUBUNIT.
ChainResidue
HSER7547
HGLY7741
HGLY7743
HGLN7773
HGLY7813
HPHE7814

site_idDC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K C 3912
ChainResidue
CGLU2841
CASN2843
CADP3910

site_idDC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K C 3913
ChainResidue
CGLU2761
CHIS2781
CGLU2783
CGLN2784
CVAL2787
CSER2792

site_idDC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL C 3930
ChainResidue
CTHR2173
CMET2174
CHOH4012

site_idDC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL C 3931
ChainResidue
CASN2289
CASN2292
CARG2294

site_idDC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL C 3932
ChainResidue
CALA2370
CASN2371
CPHE2900
CPRO2901
CGLY2902

site_idDC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL D 3933
ChainResidue
CHOH4414
DPHE3515
DASP3614
DHOH3973

site_idDC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL C 3934
ChainResidue
CPHE2578
CARG2845
CALA2847
CARG2848

site_idDC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL C 3935
ChainResidue
CHIS2070
CTRP2071

site_idDC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL C 3936
ChainResidue
CLYS2475
CASN2485

site_idEC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K C 3940
ChainResidue
CASP2084
CGLY2112
CTHR2114

site_idEC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K D 3941
ChainResidue
DHIS3516
DASP3612
DHOH3986

site_idEC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K C 3942
ChainResidue
CGLU2217
CTHR2244
CASN2283
CGLN2285
CPO43906
CHOH4122

site_idEC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K C 3943
ChainResidue
CTHR2143
CALA2144
CHOH4473
CHOH4474
CHOH4648

site_idEC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PO4 C 3980
ChainResidue
CASP2518
CGLN2519

site_idEC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PO4 C 3981
ChainResidue
CASP2592
CGLY2593

site_idEC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PO4 C 3982
ChainResidue
CLEU2801
CHOH4827
CHOH4828

site_idEC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN E 5901
ChainResidue
EGLU4299
EASN4301
EADP5900
EMN5902
EPO45906
EHOH6698

site_idEC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN E 5902
ChainResidue
EGLN4285
EGLU4299
EADP5900
EMN5901
EPO45906
EK5942
EHOH6707

site_idFC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K E 5903
ChainResidue
EGLU4215
EASN4236
EASP4238
EALA4239
EILE4242
ESER4247

site_idFC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE K E 5904
ChainResidue
EALA4126
EGLU4127
EGLU4299
EMET4300
EASN4301
EHOH6083
EHOH6698

site_idFC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE PO4 E 5906
ChainResidue
EMET4174
EGLY4175
EHIS4243
EGLN4285
EGLU4299
EASN4301
EARG4303
EARG4306
EADP5900
EMN5901
EMN5902
EK5942
EHOH6018
EHOH6128

site_idFC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MN E 5911
ChainResidue
EGLN4829
EGLU4841
EADP5910

site_idFC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K E 5912
ChainResidue
EGLU4841
EASN4843
EADP5910

site_idFC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K E 5913
ChainResidue
EGLU4761
EHIS4781
EGLU4783
EGLN4784
EVAL4787
ESER4792

site_idFC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL E 5930
ChainResidue
EGLN4093
ETHR4173
EMET4174
EHOH6013
EHOH6051

site_idFC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL E 5931
ChainResidue
EASN4289
EASN4292
EARG4294

site_idFC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL E 5932
ChainResidue
EALA4370
EASN4371
EPRO4901
EGLY4902

site_idGC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL F 5933
ChainResidue
FPHE5515
FILE5613
FASP5614

site_idGC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL E 5934
ChainResidue
EPHE4578
EALA4847
EARG4848
EHOH6824

site_idGC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL E 5935
ChainResidue
ETRP4071

site_idGC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL E 5936
ChainResidue
ELYS4475
EASN4485
EHOH6286

site_idGC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE K E 5940
ChainResidue
EASP4084
EGLY4112
ETHR4114
EHOH6431

site_idGC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE K F 5941
ChainResidue
EHOH6419
FHOH2588
FHIS5516
FASP5612

site_idGC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE K E 5942
ChainResidue
EGLU4217
ETHR4244
EASN4283
EGLN4285
EMN5902
EPO45906
EHOH6128

site_idGC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K E 5943
ChainResidue
ETHR4143
EALA4144
EHOH6483
EHOH6484
EHOH6485

site_idGC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PO4 E 5980
ChainResidue
ETYR4799
ETHR4800
ELEU4801

site_idHC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE PO4 E 5981
ChainResidue
EGLU4560

site_idHC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PO4 G 7980
ChainResidue
GLYS6475
GGLN6491

site_idHC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO4 G 7981
ChainResidue
GALA6798
GTYR6799
GTHR6800
GLEU6801

site_idHC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PO4 G 7982
ChainResidue
GASP6592
GGLY6593

site_idHC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN A 1901
ChainResidue
AGLU299
AASN301
AADP1900
APO41906
AHOH2674

site_idHC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MN A 1902
ChainResidue
AGLN285
AGLU299
AADP1900
APO41906

site_idHC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K A 1903
ChainResidue
AGLU215
AASN236
AASP238
AALA239
AILE242
ASER247

site_idHC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K A 1904
ChainResidue
AALA126
AGLU127
AGLU299
AMET300
AASN301
AHOH2674

site_idHC9
Number of Residues13
DetailsBINDING SITE FOR RESIDUE PO4 A 1906
ChainResidue
AMET174
AGLY175
AHIS243
AGLN285
AGLU299
AASN301
AARG303
AARG306
AADP1900
AMN1901
AMN1902
AK1942
AHOH2124

site_idIC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MN A 1911
ChainResidue
AGLN829
AGLU841
AADP1910

site_idIC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K A 1912
ChainResidue
AGLU841
AASN843
AADP1910

site_idIC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K A 1913
ChainResidue
AGLU761
AHIS781
AGLU783
AGLN784
AVAL787
ASER792

site_idIC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL A 1930
ChainResidue
AGLN93
ATHR173
AMET174
AHOH2013
AHOH2049

site_idIC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 1931
ChainResidue
AASN289
AASN292
AARG294

site_idIC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL A 1932
ChainResidue
AALA370
AASN371
APHE900
APRO901
AGLY902

site_idIC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL B 1933
ChainResidue
BASP1614
BHOH1972

site_idIC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 1934
ChainResidue
APHE578
AARG845
AALA847
AARG848

site_idIC9
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL A 1935
ChainResidue
ATRP71

site_idJC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL A 1936
ChainResidue
ALYS475
AASN485
APHE488
AHOH2284
AHOH2747

site_idJC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K A 1940
ChainResidue
AASP84
AGLY112
ATHR114
AHOH2426
AHOH2628

site_idJC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K B 1941
ChainResidue
BHIS1516
BASP1612
BHOH1984

site_idJC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE K A 1942
ChainResidue
AGLU217
ATHR244
AASN283
AGLN285
ASER307
APO41906
AHOH2124

site_idJC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K A 1943
ChainResidue
ATHR143
AALA144
AHOH2478

site_idJC6
Number of Residues23
DetailsBINDING SITE FOR RESIDUE ADP G 7900
ChainResidue
GHOH141
GHOH874
GARG6129
GILE6167
GARG6169
GTHR6173
GMET6174
GGLY6175
GGLY6176
GGLU6208
GLEU6210
GGLU6215
GMET6240
GGLY6241
GILE6242
GHIS6243
GTHR6244
GGLN6285
GGLU6299
GTHR6376
GMN7901
GMN7902
GPO47906

site_idJC7
Number of Residues17
DetailsBINDING SITE FOR RESIDUE ADP G 7910
ChainResidue
GHOH763
GPRO6690
GARG6715
GMET6725
GHIS6754
GPHE6755
GLEU6756
GGLU6761
GALA6785
GGLY6786
GVAL6787
GHIS6788
GSER6789
GGLN6829
GGLU6841
GMN7911
GK7912

site_idJC8
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ORN G 7920
ChainResidue
GHOH85
GHOH418
GHOH903
GGLU6783
GASP6791
GGLU6892
GVAL6893
GLEU6907
GTYR7040
GASP7041
GTHR7042

site_idJC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NET G 7950
ChainResidue
GGLN6022
GGLN6093
GTHR6094
GASN6097

site_idKC1
Number of Residues28
DetailsBINDING SITE FOR RESIDUE ADP C 3900
ChainResidue
CARG2129
CILE2167
CARG2169
CTHR2173
CMET2174
CGLY2175
CGLY2176
CGLU2208
CSER2209
CLEU2210
CILE2211
CGLU2215
CMET2240
CGLY2241
CILE2242
CHIS2243
CTHR2244
CGLN2285
CILE2298
CGLU2299
CTHR2376
CMN3901
CMN3902
CPO43906
CHOH4120
CHOH4447
CHOH4633
CHOH4661

site_idKC2
Number of Residues16
DetailsBINDING SITE FOR RESIDUE ADP C 3910
ChainResidue
CPRO2690
CARG2715
CMET2725
CHIS2754
CPHE2755
CLEU2756
CGLU2761
CALA2785
CGLY2786
CVAL2787
CHIS2788
CSER2789
CGLN2829
CGLU2841
CMN3911
CK3912

site_idKC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ORN C 3920
ChainResidue
CGLU2783
CASP2791
CALA2793
CGLU2892
CVAL2893
CLEU2907
CTYR3040
CASP3041
CTHR3042
CHOH4066
CHOH4068
CHOH4365

site_idKC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NET C 3950
ChainResidue
CTHR2094
CASN2097
CASN2936
CHOH4001

site_idKC5
Number of Residues24
DetailsBINDING SITE FOR RESIDUE ADP E 5900
ChainResidue
EARG4129
EILE4167
EARG4169
EMET4174
EGLY4175
EGLY4176
EGLU4208
ELEU4210
EILE4211
EGLU4215
EMET4240
EGLY4241
EILE4242
EHIS4243
ETHR4244
EGLN4285
EILE4298
EGLU4299
ETHR4376
EMN5901
EMN5902
EPO45906
EHOH6126
EHOH6707

site_idKC6
Number of Residues19
DetailsBINDING SITE FOR RESIDUE ADP E 5910
ChainResidue
EPRO4690
EVAL4713
EARG4715
EMET4725
EHIS4754
EPHE4755
ELEU4756
EGLU4761
EALA4785
EGLY4786
EVAL4787
EHIS4788
ESER4789
EGLN4829
EGLU4841
EPRO4909
EMN5911
EK5912
EHOH6798

site_idKC7
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ORN E 5920
ChainResidue
EGLU4783
EASP4791
EGLU4892
EVAL4893
ELEU4907
ETYR5040
EASP5041
ETHR5042
EHOH6070
EHOH6072
EHOH6370

site_idKC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NET E 5950
ChainResidue
EGLN4022
ETHR4094
EASN4097
EHOH6004

site_idKC9
Number of Residues21
DetailsBINDING SITE FOR RESIDUE ADP A 1900
ChainResidue
AARG129
AILE167
AARG169
AMET174
AGLY175
AGLY176
AGLU208
ALEU210
AGLU215
AMET240
AGLY241
AILE242
AHIS243
ATHR244
AGLN285
AGLU299
ATHR376
AMN1901
AMN1902
APO41906
AHOH2672

site_idLC1
Number of Residues20
DetailsBINDING SITE FOR RESIDUE ADP A 1910
ChainResidue
APRO690
AARG715
AMET725
AHIS754
APHE755
ALEU756
AGLU761
AALA785
AGLY786
AVAL787
AHIS788
ASER789
AGLN829
AGLU841
AMN1911
AK1912
AHOH2561
AHOH2810
AHOH2845
AHOH2846

site_idLC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ORN A 1920
ChainResidue
AGLU783
AASP791
AALA793
AGLU892
ALEU907
ATYR1040
AASP1041
ATHR1042
AHOH2070
AHOH2370

site_idLC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE NET A 1950
ChainResidue
AGLN22
ATHR94

site_idOR1
Number of Residues5
DetailsORNITHINE BINDING SITE.
ChainResidue
AASP791
AGLU783
AGLU892
ATYR1040
ATHR1042

site_idOR2
Number of Residues5
DetailsORNITHINE BINDING SITE.
ChainResidue
CASP2791
CGLU2783
CGLU2892
CTYR3040
CTHR3042

site_idOR3
Number of Residues5
DetailsORNITHINE BINDING SITE.
ChainResidue
EASP4791
EGLU4783
EGLU4892
ETYR5040
ETHR5042

site_idOR4
Number of Residues5
DetailsORNITHINE BINDING SITE.
ChainResidue
GASP6791
GGLU6783
GGLU6892
GTYR7040
GTHR7042

Functional Information from PROSITE/UniProt
site_idPS00866
Number of Residues15
DetailsCPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. FPCIIRPSftmGGsG
ChainResidueDetails
APHE164-GLY178
ATYR710-ALA724

site_idPS00867
Number of Residues8
DetailsCPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. VIEMNPRV
ChainResidueDetails
AVAL297-VAL304
ALEU839-ALA846

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209
ChainResidueDetails
BCYG1769
DCYG3769
FCYG5769
HCYG7769
AHIS243
ATHR244
AALA716
APHE755
AASP757
AVAL762
AVAL787
AHIS788
ASER789
AGLY790
CARG2130
CPRO2170
CGLY2176
CSER2177
CSER2209
CILE2211
CTYR2216
CILE2242
CHIS2243
CTHR2244
CALA2716
CPHE2755
CASP2757
CVAL2762
CVAL2787
CHIS2788
CSER2789
CGLY2790
EARG4130
EPRO4170
EGLY4176
ESER4177
ESER4209
EILE4211
ETYR4216
EILE4242
EHIS4243
ETHR4244
EALA4716
EPHE4755
EASP4757
EVAL4762
EVAL4787
EHIS4788
ESER4789
EGLY4790
GARG6130
GPRO6170
GGLY6176
GSER6177
GSER6209
GILE6211
GTYR6216
GILE6242
GHIS6243
GTHR6244
GALA6716
GPHE6755
GASP6757
GVAL6762
GVAL6787
GHIS6788
GSER6789
GGLY6790
ASER209
AILE211
ATYR216
AILE242

site_idSWS_FT_FI2
Number of Residues8
DetailsACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01209
ChainResidueDetails
HASN7853
HGLU7855
BASN1853
BGLU1855
DASN3853
DGLU3855
FASN5853
FGLU5855

site_idSWS_FT_FI3
Number of Residues32
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01209, ECO:0000269|PubMed:10587438, ECO:0007744|PDB:1C3O
ChainResidueDetails
DSER3547
DGLY3741
DGLY3743
DLEU3770
DGLN3773
DASN3811
DGLY3813
DPHE3814
FSER5547
FGLY5741
FGLY5743
FLEU5770
FGLN5773
FASN5811
FGLY5813
FPHE5814
HSER7547
HGLY7741
HGLY7743
HLEU7770
HGLN7773
HASN7811
HGLY7813
HPHE7814
BSER1547
BGLY1741
BGLY1743
BLEU1770
BGLN1773
BASN1811
BGLY1813
BPHE1814

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8
ChainResidueDetails
APHE830
CPHE2830
EPHE4830
GPHE6830

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8
ChainResidueDetails
AVAL842
CVAL2842
EVAL4842
GVAL6842

site_idSWS_FT_FI6
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390
ChainResidueDetails
APRO844
CPRO2844
EPRO4844
GPRO6844

Catalytic Information from CSA
site_idMCSA1
Number of Residues3
DetailsM-CSA 435
ChainResidueDetails
BCYG1769covalent catalysis, proton shuttle (general acid/base)
BASN1853proton shuttle (general acid/base)
BGLU1855steric role
ATYR216steric role
ATHR244proton shuttle (general acid/base)
AVAL284electrostatic stabiliser
APHE286metal ligand
AMET300metal ligand
APRO302metal ligand
AVAL304electrostatic stabiliser
AALA716electrostatic stabiliser
AGLY722electrostatic stabiliser
AARG723electrostatic stabiliser
AVAL762steric role
APHE830metal ligand
AVAL842metal ligand
APRO844metal ligand
ATHR849electrostatic stabiliser

site_idMCSA2
Number of Residues3
DetailsM-CSA 435
ChainResidueDetails
DCYG3769covalent catalysis, proton shuttle (general acid/base)
DASN3853proton shuttle (general acid/base)
DGLU3855steric role
CTYR2216steric role
CTHR2244proton shuttle (general acid/base)
CVAL2284electrostatic stabiliser
CPHE2286metal ligand
CMET2300metal ligand
CPRO2302metal ligand
CVAL2304electrostatic stabiliser
CALA2716electrostatic stabiliser
CGLY2722electrostatic stabiliser
CARG2723electrostatic stabiliser
CVAL2762steric role
CPHE2830metal ligand
CVAL2842metal ligand
CPRO2844metal ligand
CTHR2849electrostatic stabiliser

site_idMCSA3
Number of Residues3
DetailsM-CSA 435
ChainResidueDetails
FCYG5769covalent catalysis, proton shuttle (general acid/base)
FASN5853proton shuttle (general acid/base)
FGLU5855steric role
ETYR4216steric role
ETHR4244proton shuttle (general acid/base)
EVAL4284electrostatic stabiliser
EPHE4286metal ligand
EMET4300metal ligand
EPRO4302metal ligand
EVAL4304electrostatic stabiliser
EALA4716electrostatic stabiliser
EGLY4722electrostatic stabiliser
EARG4723electrostatic stabiliser
EVAL4762steric role
EPHE4830metal ligand
EVAL4842metal ligand
EPRO4844metal ligand
ETHR4849electrostatic stabiliser

site_idMCSA4
Number of Residues3
DetailsM-CSA 435
ChainResidueDetails
HCYG7769covalent catalysis, proton shuttle (general acid/base)
HASN7853proton shuttle (general acid/base)
HGLU7855steric role
GPHE6286metal ligand
GTYR6216steric role
GTHR6244proton shuttle (general acid/base)
GVAL6284electrostatic stabiliser
GMET6300metal ligand
GPRO6302metal ligand
GVAL6304electrostatic stabiliser
GALA6716electrostatic stabiliser
GGLY6722electrostatic stabiliser
GARG6723electrostatic stabiliser
GVAL6762steric role
GPHE6830metal ligand
GVAL6842metal ligand
GPRO6844metal ligand
GTHR6849electrostatic stabiliser

217705

PDB entries from 2024-03-27

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