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8U9X
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STRUCTURAL BASIS OF TRANSCRIPTION: RNA POLYMERASE II SUBSTRATE BINDING AND METAL COORDINATION AT 3.0 A OF T834P MUTANT USING A FREE-ELECTRON LASER
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ...
Authors:Arjunan, P, Calero, G, Kaplan, C.D.
Deposit date:2023-09-20
Release date:2024-09-18
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural basis of transcription: RNA polymerase II substrate binding and metal coordination using a free-electron laser.
Proc.Natl.Acad.Sci.USA, 121, 2024
8WDK
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The complex structure of Cul2-VCB-Protac-Wee1
Descriptor: (2S,4R)-1-[(2S)-3,3-dimethyl-2-[3-[4-[4-[4-[[3-oxidanylidene-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]-2-prop-2-enyl-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]piperazin-1-yl]butoxy]propanoylamino]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, E3 ubiquitin-protein ligase RBX1, ...
Authors:Wang, P, Zhang, T.T.
Deposit date:2023-09-15
Release date:2024-09-18
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Structure of Cul2-VCB-Protac-Wee1 complex at 3.6 Angstrom resolution.
To Be Published
8U9R
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STRUCTURAL BASIS OF TRANSCRIPTION: RNA POLYMERASE II SUBSTRATE BINDING AND METAL COORDINATION USING A FREE-ELECTRON LASER
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*CP*AP*CP*GP*TP*CP*CP*CP*TP*CP*TP*CP*GP*A)-3'), DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Arjunan, P, Calero, G, Kaplan, C.D.
Deposit date:2023-09-20
Release date:2024-09-18
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Structural basis of transcription: RNA polymerase II substrate binding and metal coordination using a free-electron laser.
Proc.Natl.Acad.Sci.USA, 121, 2024
9B8S
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Human polymerase epsilon bound to PCNA and DNA in the nucleotide exchange state
Descriptor: DNA (5'-D(P*AP*AP*AP*GP*TP*GP*AP*AP*AP*AP*AP*TP*CP*TP*AP*AP*AP*GP*CP*AP*TP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*AP*TP*GP*CP*TP*TP*TP*AP*GP*AP*TP*TP*TP*TP*TP*C)-3'), DNA polymerase epsilon catalytic subunit A, ...
Authors:Wang, F, He, Q, Li, H.
Deposit date:2024-03-31
Release date:2024-09-11
Last modified:2024-09-18
Method:ELECTRON MICROSCOPY (5.01 Å)
Cite:Structures of the human leading strand Pol epsilon- PCNA holoenzyme
Nat Commun, 15, 2024
9JA1
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The RNA polymerase II elongation complex from Saccharomyces cerevisiae
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*GP*CP*TP*CP*CP*TP*TP*CP*TP*CP*CP*CP*AP*TP*CP*CP*TP*CP*TP*CP*GP*AP*T)-3'), DNA (5'-D(P*TP*GP*GP*GP*AP*GP*AP*AP*GP*GP*AP*GP*C)-3'), ...
Authors:Yi, G, Ma, J, Zhang, P.
Deposit date:2024-08-23
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:The RNA polymerase II elongation complex from Saccharomyces cerevisiae
To Be Published
8B3G
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C(N)RL4CSA-UVSSA-E2-ubiquitin complex.
Descriptor: Cullin-4A, DNA damage-binding protein 1, DNA excision repair protein ERCC-8, ...
Authors:Kokic, G, Cramer, P.
Deposit date:2022-09-16
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair.
Nat.Struct.Mol.Biol., 31, 2024
8TWA
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Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA-PolE-DNA complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18, Chromosome transmission fidelity protein 8, ...
Authors:Yuan, Z, Georgescu, R, O'Donnell, M, Li, H.
Deposit date:2023-08-20
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM reveals that Ctf18-RFC collaborates with PolE to load the PCNA clamp onto a leading strand DNA
To Be Published
9EQJ
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Crystal structure of pVHL:EloB:EloC in complex with MP-1-39
Descriptor: (2S,4R)-1-[(2R)-2-[(1-fluoranylcyclopropyl)carbonylamino]-3-methyl-3-[[cis-4-(morpholin-4-ylmethyl)cyclohexyl]methylsulfanyl]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
Authors:Kroupova, A, Pierri, M, Liu, X, Ciulli, A.
Deposit date:2024-03-21
Release date:2024-08-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity.
Bioorg.Med.Chem.Lett., 110, 2024
9EQM
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Crystal structure of pVHL:EloB:EloC in complex with MP-1-21
Descriptor: (2S,4R)-1-[(2R)-2-[(1-fluoranylcyclopropyl)carbonylamino]-3-methyl-3-[[trans-4-(morpholin-4-ylmethyl)cyclohexyl]methylsulfanyl]butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
Authors:Kroupova, A, Pierri, M, Liu, X, Ciulli, A.
Deposit date:2024-03-21
Release date:2024-08-28
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity.
Bioorg.Med.Chem.Lett., 110, 2024
8T5V
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Influenza PA-N Endonuclease A36V mutant with Baloxavir
Descriptor: Baloxavir acid, MANGANESE (II) ION, Polymerase acidic protein
Authors:Kohlbrand, A.J, Cohen, S.M.
Deposit date:2023-06-14
Release date:2024-08-28
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants.
Biochemistry, 63, 2024
9F1C
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Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ...
Authors:Yudin, D, Scaiola, A, Ban, N.
Deposit date:2024-04-18
Release date:2024-08-21
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:NAC guides a ribosomal multienzyme complex for nascent protein processing.
Nature, 2024
9F1B
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Mammalian ternary complex of a translating 80S ribosome, NAC and NatA/E
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ...
Authors:Yudin, D, Scaiola, A, Ban, N.
Deposit date:2024-04-18
Release date:2024-08-21
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:NAC guides a ribosomal multienzyme complex for nascent protein processing.
Nature, 2024
9F1D
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Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E-HYPK
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ...
Authors:Yudin, D, Scaiola, A, Ban, N.
Deposit date:2024-04-18
Release date:2024-08-21
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (3.26 Å)
Cite:NAC guides a ribosomal multienzyme complex for nascent protein processing.
Nature, 2024
9F6I
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Human DNA Polymerase epsilon bound to T-C mismatched DNA (Post-Insertion state)
Descriptor: 2',3'-dideoxyadenosine triphosphate, CALCIUM ION, DNA nascent strand, ...
Authors:Roske, J.J, Yeeles, J.T.P.
Deposit date:2024-05-01
Release date:2024-08-07
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon.
Nat.Struct.Mol.Biol., 2024
9B9L
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BU of 9b9l by Molmil
RPRD1B C-terminal interacting domain bound to a pThr4 CTD peptide
Descriptor: Regulation of nuclear pre-mRNA domain-containing protein 1B, SER-PRO-THR-SER-PRO-SER-TYR-SER-PRO-TPO-SER-PRO-SER-TYR-SER
Authors:Moreno, R.Y, Zhang, Y.J.
Deposit date:2024-04-02
Release date:2024-08-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Thr4 phosphorylation primes Ser2 phosphorylation on RNA polymerase II and mediates regulation in elongation and 3'end processing
To Be Published
9F6D
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Human DNA polymerase epsilon bound to DNA and PCNA (open conformation)
Descriptor: 2',3'-dideoxyadenosine triphosphate, DNA nascent strand, DNA polymerase epsilon catalytic subunit A, ...
Authors:Roske, J.J, Yeeles, J.T.P.
Deposit date:2024-05-01
Release date:2024-08-07
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon.
Nat.Struct.Mol.Biol., 2024
9F6L
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Human DNA Polymerase epsilon bound to T-C mismatched DNA (Mismatch Excision state)
Descriptor: CALCIUM ION, DNA nascent strand, DNA polymerase epsilon catalytic subunit A, ...
Authors:Roske, J.J, Yeeles, J.T.P.
Deposit date:2024-05-01
Release date:2024-08-07
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon.
Nat.Struct.Mol.Biol., 2024
9F6J
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BU of 9f6j by Molmil
Human DNA Polymerase epsilon bound to T-C mismatched DNA (Polymerase Arrest state)
Descriptor: DNA nascent strand, DNA polymerase epsilon catalytic subunit A, DNA template strand, ...
Authors:Roske, J.J, Yeeles, J.T.P.
Deposit date:2024-05-01
Release date:2024-08-07
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon.
Nat.Struct.Mol.Biol., 2024
9F6F
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BU of 9f6f by Molmil
Human DNA polymerase epsilon bound to DNA and PCNA (closed conformation)
Descriptor: 2',3'-dideoxyadenosine triphosphate, DNA nascent strand, DNA polymerase epsilon catalytic subunit A, ...
Authors:Roske, J.J, Yeeles, J.T.P.
Deposit date:2024-05-01
Release date:2024-08-07
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon.
Nat.Struct.Mol.Biol., 2024
9F6K
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BU of 9f6k by Molmil
Human DNA Polymerase epsilon bound to T-C mismatched DNA (Frayed Substrate state)
Descriptor: DNA nascent strand, DNA polymerase epsilon catalytic subunit A, DNA template strand, ...
Authors:Roske, J.J, Yeeles, J.T.P.
Deposit date:2024-05-01
Release date:2024-08-07
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon.
Nat.Struct.Mol.Biol., 2024
9F6E
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BU of 9f6e by Molmil
Human DNA polymerase epsilon bound to DNA and PCNA (ajar conformation)
Descriptor: 2',3'-dideoxyadenosine triphosphate, DNA nascent strand, DNA polymerase epsilon catalytic subunit A, ...
Authors:Roske, J.J, Yeeles, J.T.P.
Deposit date:2024-05-01
Release date:2024-08-07
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (3.74 Å)
Cite:Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon.
Nat.Struct.Mol.Biol., 2024
8VJ0
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BU of 8vj0 by Molmil
Neutron Structure of Oxidized Trp161Phe MnSOD
Descriptor: MANGANESE (II) ION, Superoxide dismutase [Mn], mitochondrial
Authors:Azadmanesh, J, Slobodnik, K, Struble, L.R, Lutz, W.E, Weiss, K.L, Myles, D.A.A, Kroll, T, Borgstahl, G.E.O.
Deposit date:2024-01-05
Release date:2024-07-31
Method:NEUTRON DIFFRACTION (2.3 Å)
Cite:Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition.
Biorxiv, 2024
8VJ4
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X-ray Counterpart to the Neutron Structure of Peroxide-Soaked Trp161Phe MnSOD
Descriptor: HYDROGEN PEROXIDE, MANGANESE (II) ION, Superoxide dismutase [Mn], ...
Authors:Azadmanesh, J, Slobodnik, K, Struble, L.R, Lutz, W.E, Weiss, K.L, Myles, D.A.A, Kroll, T, Borgstahl, G.E.O.
Deposit date:2024-01-05
Release date:2024-07-31
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition.
Biorxiv, 2024
8VJ8
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X-ray Counterpart to Neutron Structure of Reduced Trp161Phe MnSOD
Descriptor: MANGANESE (II) ION, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Azadmanesh, J, Slobodnik, K, Struble, L.R, Lutz, W.E, Weiss, K.L, Myles, D.A.A, Kroll, T, Borgstahl, G.E.O.
Deposit date:2024-01-05
Release date:2024-07-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition.
Biorxiv, 2024
8VHW
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BU of 8vhw by Molmil
Neutron Structure of Peroxide-Soaked Trp161Phe MnSOD
Descriptor: HYDROGEN PEROXIDE, MANGANESE (II) ION, Superoxide dismutase [Mn], ...
Authors:Azadmanesh, J, Slobodnik, K, Struble, L.R, Lutz, W.E, Coates, L, Weiss, K.L, Myles, D.A.A, Kroll, T, Borgstahl, G.E.O.
Deposit date:2024-01-02
Release date:2024-07-31
Method:NEUTRON DIFFRACTION (2.3 Å)
Cite:Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition.
Biorxiv, 2024

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PDB entries from 2024-09-18

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