9F6J

Human DNA Polymerase epsilon bound to T-C mismatched DNA (Polymerase Arrest state)

Summary for 9F6J

Entry DOI	10.2210/pdb9f6j/pdb
EMDB information	50226
Descriptor	DNA polymerase epsilon catalytic subunit A, DNA nascent strand, DNA template strand, ... (4 entities in total)
Functional Keywords	dna, polymerase, epsilon, pcna, leading strand, human, replication, replisome, proofreading
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	157436.42
Authors	Roske, J.J.,Yeeles, J.T.P. (deposition date: 2024-05-01, release date: 2024-08-07, Last modification date: 2024-08-21)
Primary citation	Roske, J.J.,Yeeles, J.T.P. Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon. Nat.Struct.Mol.Biol., 2024 Cited by PubMed: 39112807 DOI: 10.1038/s41594-024-01370-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.9 Å)

Structure validation