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3WGX
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BU of 3wgx by Molmil
Crystal structure of ERp46 Trx2 in a complex with Prx4 C-term
Descriptor: GLYCEROL, Peroxiredoxin-4, Thioredoxin domain-containing protein 5
Authors:Inaba, K, Suzuki, M, Kojima, R.
Deposit date:2013-08-13
Release date:2014-06-25
Method:X-RAY DIFFRACTION (0.92 Å)
Cite:Radically different thioredoxin domain arrangement of ERp46, an efficient disulfide bond introducer of the mammalian PDI family
Structure, 22, 2014
5YKJ
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BU of 5ykj by Molmil
Structural basis of the thiol resolving mechanism in yeast mitochondrial 1-Cys peroxiredoxin via glutathione/thioredoxin systems
Descriptor: GLYCEROL, Peroxiredoxin PRX1, mitochondrial, ...
Authors:Li, C.C, Yang, J, Yang, M.J, Liu, L, Peng, C.T, Li, T, He, L.H, Song, Y.J, Zhu, Y.B, Zhao, N.L, Zhao, C, Bao, R.
Deposit date:2017-10-14
Release date:2018-10-24
Last modified:2019-11-06
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Structural basis of the thiol resolving mechanism in yeast mitochondrial 1-Cys peroxiredoxin via glutathione/thioredoxin systems
To be published
8X71
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BU of 8x71 by Molmil
Crystal structure of Peroxiredoxin I in complex with compound 19-064
Descriptor: Peroxiredoxin-1, methyl 3-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]oxetane-3-carboxylate
Authors:Zhang, H, Luo, C.
Deposit date:2023-11-22
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors.
J.Med.Chem., 67, 2024
2V2G
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BU of 2v2g by Molmil
Crystal Structure of the C45S mutant of the Peroxiredoxin 6 of Arenicola Marina. Monoclinic form
Descriptor: BENZOIC ACID, GLYCEROL, PEROXIREDOXIN 6
Authors:Smeets, A, Declercq, J.P.
Deposit date:2007-06-05
Release date:2008-04-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The Crystal Structure of the C45S Mutant of Annelid Arenicola Marina Peroxiredoxin 6 Supports its Assignment to the Mechanistically Typical 2- Cys Subfamily without Any Formation of Toroid- Shaped Decamers.
Protein Sci., 17, 2008
8X73
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BU of 8x73 by Molmil
Crystal structure of Peroxiredoxin I in complex with compound 19-069
Descriptor: Peroxiredoxin-1, methyl (2~{S})-2-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]-3-oxidanyl-propanoate
Authors:Zhang, H, Luo, C.
Deposit date:2023-11-22
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors.
J.Med.Chem., 67, 2024
3A2V
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BU of 3a2v by Molmil
Peroxiredoxin (C207S) from Aeropyrum pernix K1 complexed with hydrogen peroxide
Descriptor: PEROXIDE ION, Probable peroxiredoxin
Authors:Nakamura, T, Kado, Y, Yamaguchi, F, Ishikawa, K, Matsumura, H, Inoue, T.
Deposit date:2009-06-04
Release date:2009-10-27
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of peroxiredoxin from Aeropyrum pernix K1 complexed with its substrate, hydrogen peroxide
J.Biochem., 147, 2010
7KIZ
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BU of 7kiz by Molmil
reduced human peroxiredoxin 2
Descriptor: Peroxiredoxin-2
Authors:Kean, K.M, Karplus, P.A.
Deposit date:2020-10-25
Release date:2021-03-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2.
J.Biol.Chem., 296, 2021
1QMV
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BU of 1qmv by Molmil
thioredoxin peroxidase B from red blood cells
Descriptor: PEROXIREDOXIN-2
Authors:Isupov, M.N, Littlechild, J.A, Lebedev, A.A, Errington, N, Vagin, A.A, Schroder, E.
Deposit date:1999-10-07
Release date:2000-07-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of Decameric 2-Cys Peroxiredoxin from Human Erythrocytes at 1.7 A Resolution.
Structure, 8, 2000
2ZCT
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BU of 2zct by Molmil
Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate
Descriptor: Probable peroxiredoxin
Authors:Nakamura, T, Hagihara, Y, Abe, M, Inoue, T, Yamamoto, T, Matsumura, H.
Deposit date:2007-11-12
Release date:2008-05-27
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate
Proc.Natl.Acad.Sci.Usa, 105, 2008
4XRA
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BU of 4xra by Molmil
Salmonella typhimurium AhpC T43S mutant
Descriptor: Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, POTASSIUM ION, ...
Authors:Perkins, A, Brereton, A.E, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A.
Deposit date:2015-01-20
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
Antioxid.Redox Signal., 28, 2018
7WET
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BU of 7wet by Molmil
Crystal structure of Peroxiredoxin I in complex with the inhibitor Cela
Descriptor: (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid, Peroxiredoxin-1
Authors:Zhang, H, Luo, C.
Deposit date:2021-12-24
Release date:2022-12-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1.
Signal Transduct Target Ther, 8, 2023
2C0D
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BU of 2c0d by Molmil
Structure of the mitochondrial 2-cys peroxiredoxin from Plasmodium falciparum
Descriptor: THIOREDOXIN PEROXIDASE 2
Authors:Boucher, I.W, Brannigan, J.A, Wilkinson, A.J, Brzozowski, A.M, Muller, S.
Deposit date:2005-09-01
Release date:2006-11-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural and Biochemical Characterisation of a Mitochondrial Peroxiredoxin from Plasmodium Falciparum
Mol.Microbiol., 61, 2006
6KRK
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BU of 6krk by Molmil
Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) 0Cys mutant
Descriptor: CITRIC ACID, Peroxiredoxin
Authors:Himiyama, T, Nakamura, T.
Deposit date:2019-08-22
Release date:2020-07-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Disassembly of the ring-type decameric structure of peroxiredoxin from Aeropyrum pernix K1 by amino acid mutation.
Protein Sci., 29, 2020
6KRM
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BU of 6krm by Molmil
Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) 0Cys F46A mutant
Descriptor: CITRIC ACID, Peroxiredoxin
Authors:Himiyama, T, Nakamura, T.
Deposit date:2019-08-22
Release date:2020-07-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Disassembly of the ring-type decameric structure of peroxiredoxin from Aeropyrum pernix K1 by amino acid mutation.
Protein Sci., 29, 2020
5OVQ
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BU of 5ovq by Molmil
Crystal Structure of the peroxiredoxin (AhpC2) from the Hyperthermophilic bacteria Aquifex aeolicus VF
Descriptor: Peroxiredoxin, UNKNOWN LIGAND
Authors:Warkentin, E, Peng, G.
Deposit date:2017-08-29
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural properties of the peroxiredoxin AhpC2 from the hyperthermophilic eubacterium Aquifex aeolicus.
Biochim Biophys Acta Gen Subj, 1862, 2018
2PN8
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BU of 2pn8 by Molmil
Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase)
Descriptor: Peroxiredoxin-4
Authors:Pilka, E.S, Kavanagh, K.L, Cooper, C, von Delft, F, Sundstrom, M, Arrowsmith, C.A, Weigelt, J, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2007-04-24
Release date:2007-05-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase).
To be Published
3VWV
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BU of 3vwv by Molmil
crystal structure of N-terminally truncated peroxiredoxin 4 from M. musculus
Descriptor: ACETIC ACID, PENTAETHYLENE GLYCOL, Peroxiredoxin-4
Authors:Inaba, K, Suzuki, M.
Deposit date:2012-09-03
Release date:2013-09-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding
Sci Rep, 3, 2013
7WEU
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BU of 7weu by Molmil
Crystal structure of Peroxiredoxin I in complex with compound 19-048
Descriptor: Peroxiredoxin-1, UNKNOWN LIGAND
Authors:Zhang, H, Luo, C.
Deposit date:2021-12-24
Release date:2022-12-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1.
Signal Transduct Target Ther, 8, 2023
4MA9
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BU of 4ma9 by Molmil
Wild type Salmonella Alkyl Hydroperoxide Reductase C in its substrate-ready conformation
Descriptor: Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, GLYCEROL, ...
Authors:Perkins, A, Karplus, P.A.
Deposit date:2013-08-15
Release date:2013-11-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:The sensitive balance between the fully folded and locally unfolded conformations of a model peroxiredoxin.
Biochemistry, 52, 2013
6KRP
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BU of 6krp by Molmil
Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) 0Cys W88A mutant
Descriptor: CITRIC ACID, Peroxiredoxin
Authors:Himiyama, T, Nakamura, T.
Deposit date:2019-08-22
Release date:2020-07-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Disassembly of the ring-type decameric structure of peroxiredoxin from Aeropyrum pernix K1 by amino acid mutation.
Protein Sci., 29, 2020
4MAB
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BU of 4mab by Molmil
Resolving Cys to Ala variant of Salmonella Alkyl Hydroperoxide Reductase C in its substrate-ready conformation
Descriptor: Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, GLYCEROL, ...
Authors:Perkins, A, Nelson, K.J, Williams, J.R, Poole, L.B, Karplus, P.A.
Deposit date:2013-08-15
Release date:2013-11-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The sensitive balance between the fully folded and locally unfolded conformations of a model peroxiredoxin.
Biochemistry, 52, 2013
3A2X
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BU of 3a2x by Molmil
Peroxiredoxin (C50S) from Aeropyrum pernix K1 (acetate-bound form)
Descriptor: ACETATE ION, Probable peroxiredoxin
Authors:Nakamura, T, Kado, Y, Yamaguchi, F, Matsumura, H, Ishikawa, K, Inoue, T.
Deposit date:2009-06-04
Release date:2009-10-27
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of peroxiredoxin from Aeropyrum pernix K1 complexed with its substrate, hydrogen peroxide
J.Biochem., 147, 2010
3QPM
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BU of 3qpm by Molmil
Crystal structure of peroxiredoxin Prx4 from Pseudosciaena crocea
Descriptor: GLYCEROL, Peroxiredoxin
Authors:Lian, F.M, Teng, Y.B, Jiang, Y.L, He, Y.X, Chen, Y, Zhou, C.Z.
Deposit date:2011-02-14
Release date:2012-02-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The N-terminal beta-sheet of peroxiredoxin Prx4 in the large yellow croaker Pseudosciaena crocea is critical for its peroxidase and anti-bacterial activities
To be Published
5UKA
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BU of 5uka by Molmil
Salmonella typhimurium AhpC E49Q mutant
Descriptor: Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, POTASSIUM ION, ...
Authors:Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A.
Deposit date:2017-01-20
Release date:2018-01-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
Antioxid.Redox Signal., 28, 2018
3TJJ
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BU of 3tjj by Molmil
Crystal structure of human peroxiredoxin IV C245A mutant in sulfenylated form
Descriptor: Peroxiredoxin-4
Authors:Cao, Z, Tavender, T.J, Roszak, A.W, Cogdell, R.J, Bulleid, N.J.
Deposit date:2011-08-24
Release date:2011-10-12
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal Structure of Reduced and of Oxidized Peroxiredoxin IV Enzyme Reveals a Stable Oxidized Decamer and a Non-disulfide-bonded Intermediate in the Catalytic Cycle.
J.Biol.Chem., 286, 2011

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PDB entries from 2024-09-18

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