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1A0M
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BU of 1a0m by Molmil
1.1 ANGSTROM CRYSTAL STRUCTURE OF A-CONOTOXIN [TYR15]-EPI
Descriptor: ALPHA-CONOTOXIN [TYR15]-EPI
Authors:Hu, S.-H, Loughnan, M, Miller, R, Weeks, C.M, Blessing, R.H, Alewood, P.F, Lewis, R.J, Martin, J.L.
Deposit date:1997-12-03
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:The 1.1 A resolution crystal structure of [Tyr15]EpI, a novel alpha-conotoxin from Conus episcopatus, solved by direct methods.
Biochemistry, 37, 1998
1AKG
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BU of 1akg by Molmil
ALPHA-CONOTOXIN PNIB FROM CONUS PENNACEUS
Descriptor: ALPHA-CONOTOXIN PNIB
Authors:Hu, S.-H, Martin, J.L.
Deposit date:1997-05-18
Release date:1998-05-20
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structure at 1.1 A resolution of alpha-conotoxin PnIB: comparison with alpha-conotoxins PnIA and GI.
Biochemistry, 36, 1997
4TTL
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BU of 4ttl by Molmil
Racemic structure of cyclic Vc1.1 (cVc1.1-1)
Descriptor: Alpha-conotoxin Vc1A
Authors:Wang, C.K, King, G.J, Craik, D.J.
Deposit date:2014-06-22
Release date:2014-09-10
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.7004 Å)
Cite:Racemic and Quasi-Racemic X-ray Structures of Cyclic Disulfide-Rich Peptide Drug Scaffolds.
Angew.Chem.Int.Ed.Engl., 53, 2014
5CO5
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BU of 5co5 by Molmil
Crystal structure of Ac-AChBP in complex with conotoxin GIC
Descriptor: Alpha-conotoxin GIC, Soluble acetylcholine receptor
Authors:Wang, X.Q, Xu, M.Y, Luo, S.L, Lin, B.
Deposit date:2015-07-19
Release date:2016-07-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of Ac-AChBP in complex with conotoxin GIC
To Be Published
5JME
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BU of 5jme by Molmil
Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin PeIA
Descriptor: Soluble acetylcholine receptor, alpha-conotoxin PeIA from Conus pergrandis
Authors:Bobango, J, Sankaran, B, McIntosh, J.M, Talley, T.T.
Deposit date:2016-04-28
Release date:2016-05-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.336 Å)
Cite:Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin PeIA
To Be Published
7N43
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BU of 7n43 by Molmil
Alpha-conotoxin OmIA with unusual pharmacological properties at alpha7 nicotinic receptors
Descriptor: Acetylcholine-binding protein, Alpha-conotoxin OmIA
Authors:Ho, T.N.T, Abraham, N, Lewis, R.J.
Deposit date:2021-06-03
Release date:2021-12-01
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Unique Pharmacological Properties of alpha-Conotoxin OmIA at alpha 7 nAChRs.
Front Pharmacol, 12, 2021
6M4Z
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BU of 6m4z by Molmil
Co-crystal structure of Ac-AChBPP in complex with alpha-conotoxin [D11A]LvIA
Descriptor: Alpha-conotoxin LvIA, Soluble acetylcholine receptor
Authors:Wang, X.Q, Pan, S, Luo, S.L, Zhu, X.P.
Deposit date:2020-03-09
Release date:2021-03-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:The crystal structure of Ac-AChBP in complex with LvIA analogs reveals the mechanism of its selectivity towards different nAChR subtypes
To Be Published
6M4X
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Co-crystal structure of Ac-AChBPP in complex with [N9A]LvIA
Descriptor: Alpha-conotoxin LvIA, Soluble acetylcholine receptor
Authors:Wang, X.Q, Pan, S, Luo, S.L, Zhu, X.P.
Deposit date:2020-03-09
Release date:2021-03-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.998 Å)
Cite:The crystal structure of Ac-AChBP in complex with LvIA analogs reveals the mechanism of its selectivity towards different nAChR subtypes
To Be Published
5XGL
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BU of 5xgl by Molmil
Co-crystal structure of Ac-AChBPP in complex with alpha-conotoxin LvIA
Descriptor: Alpha-conotoxin LvIA, Soluble acetylcholine receptor
Authors:Wang, X.Q, Xu, M.Y, Luo, S.L, Zhu, X.P.
Deposit date:2017-04-14
Release date:2018-06-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.439 Å)
Cite:The crystal structure of Ac-AChBP in complex with alpha-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes
Protein Cell, 8, 2017
2GCZ
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BU of 2gcz by Molmil
Solution Structure of alpha-Conotoxin OmIA
Descriptor: Alpha-conotoxin OmIA
Authors:Chi, S.-W, Kim, D.-H, Olivera, B.M, McIntosh, J.M, Han, K.-H.
Deposit date:2006-03-15
Release date:2006-07-25
Last modified:2020-06-24
Method:SOLUTION NMR
Cite:Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes
Biochem.Biophys.Res.Commun., 345, 2006
7KNN
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BU of 7knn by Molmil
Solution structure of the alpha-conotoxin analogue [2-8]-alkyne Vc1.1
Descriptor: Alpha-conotoxin Vc1a
Authors:MacRaild, C.A, Robinson, S.D, Chhabra, S, Norton, R.S.
Deposit date:2020-11-05
Release date:2021-09-15
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Alkyne-Bridged alpha-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models.
J.Med.Chem., 64, 2021
1DG2
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BU of 1dg2 by Molmil
SOLUTION CONFORMATION OF A-CONOTOXIN AUIB
Descriptor: A-CONOTOXIN AUIB
Authors:Cho, J.-H, Mok, K.H, Olivera, B.M, McIntosh, J.M, Park, K.-H, Han, K.-H.
Deposit date:1999-11-23
Release date:2000-02-25
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance solution conformation of alpha-conotoxin AuIB, an alpha(3)beta(4) subtype-selective neuronal nicotinic acetylcholine receptor antagonist.
J.Biol.Chem., 275, 2000
1IEN
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BU of 1ien by Molmil
SOLUTION STRUCTURE OF TIA
Descriptor: PROTEIN TIA
Authors:Sharpe, I.A, Gehrmann, J, Loughnan, M.L, Thomas, L, Adams, D.A, Atkins, A, Palant, E, Craik, D.J, Adams, D.J, Alewood, P.F, Lewis, R.J.
Deposit date:2001-04-10
Release date:2002-04-03
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter.
Nat.Neurosci., 4, 2001
6CGX
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BU of 6cgx by Molmil
Backbone cyclised conotoxin Vc1.1 mutant - D11A, E14A
Descriptor: Alpha-conotoxin Vc1A
Authors:Clark, R.J.
Deposit date:2018-02-21
Release date:2018-05-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure-Activity Studies Reveal the Molecular Basis for GABAB-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by alpha-Conotoxin Vc1.1.
ACS Chem. Biol., 13, 2018
5UG3
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BU of 5ug3 by Molmil
NMR SOLUTION STRUCTURE OF ALPHA-CONOTOXIN GID MUTANT A10V
Descriptor: Alpha-conotoxin GID
Authors:Hussein, A.K, Leffler, A.E, Zebroski, H.A, Powell, S.R, Kuryatov, A, Filipenko, P, Gorson, J, Heizmann, A, Lyskov, S, Nicke, A, Lindstrom, J, Rudy, B, Bonneau, R, Holford, M, Poget, S.F.
Deposit date:2017-01-06
Release date:2017-09-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UG5
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BU of 5ug5 by Molmil
NMR SOLUTION STRUCTURE OF THE ALPHA-CONOTOXIN GID MUTANT V13Y
Descriptor: Alpha-conotoxin GID
Authors:Hussein, A, Leffler, A.E, Kuryatov, A, Zebroski, H.A, Powell, S.R, Filipenko, P, Gorson, J, Heizmann, A, Lyskov, S, Nicke, A, Lindstrom, J, Rudy, B, Bonneau, R, Holford, M, Poget, S.F.
Deposit date:2017-01-06
Release date:2017-09-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
2MG6
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BU of 2mg6 by Molmil
Non-reducible analogues of alpha-conotoxin Vc1.1: [3,16]-trans dicarba Vc1.1
Descriptor: Alpha-conotoxin Vc1A
Authors:Robinson, S.D, Macraild, C.A, Van Lierop, B.J, Robinson, A.J, Norton, R.S.
Deposit date:2013-10-28
Release date:2013-12-18
Method:SOLUTION NMR
Cite:Dicarba alpha-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors.
Acs Chem.Biol., 8, 2013
2LR9
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BU of 2lr9 by Molmil
High-resolution solution NMR structure of the rho-conotoxin TIA.
Descriptor: Rho-conotoxin TIA
Authors:Rosengren, K, Lewis, R.J.
Deposit date:2012-03-27
Release date:2012-05-02
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Conopeptide rho-TIA defines a new allosteric site on the extracellular surface of the alpha 1B-adrenoceptor.
J.Biol.Chem., 288, 2013
2MFY
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BU of 2mfy by Molmil
Non-reducible analogues of alpha-conotoxin Vc1.1: [2,8]-trans dicarba Vc1.1
Descriptor: Alpha-conotoxin Vc1A
Authors:Robinson, S.D, Macraild, C.A, Van Lierop, B.J, Robinson, A.J, Norton, R.S.
Deposit date:2013-10-24
Release date:2013-12-18
Method:SOLUTION NMR
Cite:Dicarba alpha-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors.
Acs Chem.Biol., 8, 2013
2MFX
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BU of 2mfx by Molmil
Non-reducible analogues of alpha-conotoxin Vc1.1: [2,8]-cis dicarba Vc1.1
Descriptor: Alpha-conotoxin Vc1A
Authors:Robinson, S.D, Macraild, C.A, Van Lierop, B.J, Robinson, A.J, Norton, R.S.
Deposit date:2013-10-24
Release date:2013-12-18
Method:SOLUTION NMR
Cite:Dicarba alpha-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors.
Acs Chem.Biol., 8, 2013
2MDQ
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BU of 2mdq by Molmil
A Novel 4/7-Conotoxin LvIA from Conus lividus that Selectively Blocks 3 2 vs. 6/3 2 3 Nicotinic Acetylcholine Receptors
Descriptor: Alpha-conotoxin-like
Authors:Schroeder, C.I.
Deposit date:2013-09-16
Release date:2014-02-12
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:A novel alpha 4/7-conotoxin LvIA from Conus lividus that selectively blocks alpha 3 beta 2 vs. alpha 6/ alpha 3 beta 2 beta 3 nicotinic acetylcholine receptors.
Faseb J., 28, 2014
1MII
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BU of 1mii by Molmil
SOLUTION STRUCTURE OF ALPHA-CONOTOXIN MII
Descriptor: PROTEIN (ALPHA CONOTOXIN MII)
Authors:Hill, J.M, Oomen, C.J, Miranda, L.P, Bingham, J.P, Alewood, P.F, Craik, D.J.
Deposit date:1998-10-05
Release date:1998-10-21
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Three-dimensional solution structure of alpha-conotoxin MII by NMR spectroscopy: effects of solution environment on helicity.
Biochemistry, 37, 1998
2LZ5
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BU of 2lz5 by Molmil
Solution structure of a Novel Alpha-Conotoxin TxIB
Descriptor: Conotoxin_TxIB
Authors:Luo, S, Zhangsun, D, Wu, Y, Zhu, X, Hu, Y, McIntyre, M, Christensen, S, Akcan, M, Craik, D, McIntosh, J.
Deposit date:2012-09-23
Release date:2012-12-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Characterization of a novel alpha-conotoxin from conus textile that selectively targets alpha6/alpha3beta2beta3 nicotinic acetylcholine receptors.
J.Biol.Chem., 288, 2013
2MD6
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NMR SOLUTION STRUCTURE OF ALPHA CONOTOXIN LO1A FROM Conus longurionis
Descriptor: ALPHA CONOTOXIN LO1A
Authors:Maiti, M, Lescrinier, E, Herdewijn, P, Lebbe, E.K.M, Peigneur, S, D'Souza, L, Tytgat, J.
Deposit date:2013-09-01
Release date:2014-03-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure-Function Elucidation of a New alpha-Conotoxin, Lo1a, from Conus longurionis.
J.Biol.Chem., 289, 2014
2M3I
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Characterization of a Novel Alpha4/6-Conotoxin TxIC from Conus textile that Potently Blocks alpha3beta4 Nicotinic Acetylcholine Receptors
Descriptor: Alpha-conotoxin
Authors:Luo, S, Zhangsun, D, Zhu, X, Wu, Y, Hu, Y, Christensen, S, Akcan, M, Craik, D.J, McIntosh, J.M.
Deposit date:2013-01-20
Release date:2013-12-04
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Characterization of a Novel alpha-Conotoxin TxID from Conus textile That Potently Blocks Rat alpha 3 beta 4 Nicotinic Acetylcholine Receptors.
J.Med.Chem., 56, 2013

 

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