2KUD
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NMR STRUCTURE OF THE PASTA DOMAIN 1 AND 2 OF MYCOBACTERIUM TUBERCULOSIS OF PKNB
Descriptor:Serine/threonine-protein kinase pknB
Authors:Barthe, P., Mukamolova, G., Roumestand, C., Cohen-Gonsaud, M.
Deposit date:2010-02-17
Release date:2010-04-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation
Structure, 18, 2010
2KUE
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NMR STRUCTURE OF THE PASTA DOMAIN 2 AND 3 OF MYCOBACTERIUM TUBERCULOSIS OF PKNB
Descriptor:Serine/threonine-protein kinase pknB
Authors:Barthe, P., Mukamolova, G., Roumestand, C., Cohen-Gonsaud, M.
Deposit date:2010-02-17
Release date:2010-04-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation
Structure, 18, 2010
2KUF
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NMR STRUCTURE OF THE PASTA DOMAIN 3 AND 4 OF MYCOBACTERIUM TUBERCULOSIS OF PKNB
Descriptor:Serine/threonine-protein kinase pknB
Authors:Barthe, P., Mukamolova, G., Roumestand, C., Cohen-Gonsaud, M.
Deposit date:2010-02-17
Release date:2010-04-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation
Structure, 18, 2010
2KUI
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NMR STRUCTURE OF THE PASTA DOMAIN OF MYCOBACTERIUM TUBERCULOSIS OF PKNB
Descriptor:Serine/threonine-protein kinase pknB
Authors:Barthe, P., Mukamolova, G., Roumestand, C., Cohen-Gonsaud, M.
Deposit date:2010-02-17
Release date:2010-04-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation
Structure, 18, 2010
2MGV
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NMR STRUCTURE OF PASTA DOMAIN OF PONA2 FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Bifunctional membrane-associated penicillin-binding protein 1A/1B ponA2
Authors:Calvanese, L., Falcigno, L., Maglione, C., Marasco, D., Ruggiero, A., Squeglia, F., Berisio, R., D'Auria, G.
Deposit date:2013-11-11
Release date:2013-12-25
Last modified:2014-05-07
Method:SOLUTION NMR
Cite:Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis.
Biopolymers, 101, 2014
3M9G
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CRYSTAL STRUCTURE OF THE THREE-PASTA-DOMAIN OF A SER/THR KINASE FROM STAPHYLOCOCCUS AUREUS
Descriptor:Protein kinase, ZINC ION
Authors:Paracuellos, P., Ballandras, A., Robert, X., Creze, C., Cozzone, A.J., Duclos, B., Gouet, P.
Deposit date:2010-03-22
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Extended Conformation of the 2.9-A Crystal Structure of the Three-PASTA Domain of a Ser/Thr Kinase from the Human Pathogen Staphylococcus aureus
J.Mol.Biol., 404, 2010
3OUV
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SEMET DERIVATIVE OF L512M MUTANT OF PASTA DOMAIN 3 OF MYCOBACTERIUM TUBERCULOSIS PKNB
Descriptor:Serine/threonine protein kinase
Authors:Prigozhin, D.M., Chen, T.Y., Alber, T.
Deposit date:2010-09-15
Release date:2011-09-21
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site.
J.Biol.Chem., 291, 2016
3PY9
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X-RAY STRUCTURAL STUDIES OF THE ENTIRE EXTRA-CELLULAR REGION OF THE SER/THR KINASE PRKC FROM STAPHYLOCOCCUS AUREUS
Descriptor:Protein kinase, EUROPIUM ION
Authors:Ruggiero, A., Squeglia, F., Marasco, D., Marchetti, R., Molinaro, A., Berisio, R.
Deposit date:2010-12-12
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray structural studies of the entire extracellular region of the serine/threonine kinase PrkC from Staphylococcus aureus.
Biochem.J., 435, 2011
5E0Y
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CRYSTAL STRUCTURE OF PASTA DOMAIN 4 OF MYCOBACTERIUM TUBERCULOSIS PROTEIN KINASE B
Descriptor:Serine/threonine-protein kinase PknB, ZINC ION
Authors:Prigozhin, D.M., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-09-29
Release date:2016-09-14
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site.
J.Biol.Chem., 291, 2016
5E0Z
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CRYSTAL STRUCTURE OF PASTA DOMAINS 3 AND 4 OF MYCOBACTERIUM TUBERCULOSIS PROTEIN KINASE B
Descriptor:Serine/threonine-protein kinase PknB
Authors:Prigozhin, D.M., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-09-29
Release date:2016-09-14
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site.
J.Biol.Chem., 291, 2016
5E10
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CRYSTAL STRUCTURE OF PASTA DOMAINS 1 AND 2 OF MYCOBACTERIUM TUBERCULOSIS PROTEIN KINASE B
Descriptor:Serine/threonine-protein kinase PknB
Authors:Prigozhin, D.M., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-09-29
Release date:2016-09-14
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site.
J.Biol.Chem., 291, 2016
5E12
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CRYSTAL STRUCTURE OF PASTA DOMAINS 2, 3 AND 4 OF MYCOBACTERIUM TUBERCULOSIS PROTEIN KINASE B
Descriptor:Serine/threonine-protein kinase PknB, CITRATE ANION
Authors:Prigozhin, D.M., TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-09-29
Release date:2016-09-14
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.208 Å)
Cite:Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site.
J.Biol.Chem., 291, 2016
5NOD
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PASTA SUBUNIT 4 OF STREPTOCOCCUS PNEUMONIAE STKP CRYSTALLIZED WITH PEG AND SUCCINATE
Descriptor:Serine/threonine-protein kinase StkP
Authors:GALISSON, F., GUEGUEN-CHAIGNON, V., GOUET, P., GRANGEASSE, C., ZUCCHINI, L.
Deposit date:2017-04-12
Release date:2017-11-08
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:PASTA repeats of the protein kinase StkP interconnect cell constriction and separation of Streptococcus pneumoniae.
Nat Microbiol, 3, 2018
1K25
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PBP2X FROM A HIGHLY PENICILLIN-RESISTANT STREPTOCOCCUS PNEUMONIAE CLINICAL ISOLATE
Descriptor:low-affinity PENICILLIN-BINDING PROTEIN 2X
Authors:Dessen, A., Mouz, N., Hopkins, J., Dideberg, O.
Deposit date:2001-09-26
Release date:2001-10-31
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations.
J.Biol.Chem., 276, 2001
1PMD
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PENICILLIN-BINDING PROTEIN 2X (PBP-2X)
Descriptor:PEPTIDOGLYCAN SYNTHESIS MULTIFUNCTIONAL ENZYME
Authors:Pares, S., Mouz, N., Dideberg, O.
Deposit date:1996-02-05
Release date:1997-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme.
Nat.Struct.Biol., 3, 1996
1PYY
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DOUBLE MUTANT PBP2X T338A/M339F FROM STREPTOCOCCUS PNEUMONIAE STRAIN R6 AT 2.4 A RESOLUTION
Descriptor:Penicillin-binding protein 2X, SULFATE ION, N-OCTANOYLSUCROSE, ...
Authors:Chesnel, L., Pernot, L., Lemaire, D., Champelovier, D., Croize, J., Dideberg, O., Vernet, T., Zapun, A.
Deposit date:2003-07-09
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:The Structural Modifications Induced by the M339F Substitution in PBP2x from Streptococcus pneumoniae Further Decreases the Susceptibility to beta-Lactams of Resistant Strains
J.Biol.Chem., 278, 2003
1QME
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PENICILLIN-BINDING PROTEIN 2X (PBP-2X)
Descriptor:PENICILLIN-BINDING PROTEIN 2X, SULFATE ION
Authors:Gordon, E.J., Mouz, N., Duee, E., Dideberg, O.
Deposit date:1999-09-28
Release date:2000-05-25
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Crystal Structure of the Penicillin-Binding Protein 2X from Streptococcus Pneumoniae and its Acyl-Enzyme Form: Implication in Drug Resistance.
J.Mol.Biol., 299, 2000
1QMF
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PENICILLIN-BINDING PROTEIN 2X (PBP-2X) ACYL-ENZYME COMPLEX
Descriptor:PENICILLIN-BINDING PROTEIN 2X, 2-[CARBOXY-(2-FURAN-2-YL-2-METHOXYIMINO-ACETYLAMINO)-METHYL]-5-METHYL-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, CEFUROXIME (OCT-3-ENE FORM)
Authors:Gordon, E.J., Mouz, N., Duee, E., Dideberg, O.
Deposit date:1999-09-28
Release date:2000-05-25
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Crystal Structure of the Penicillin Binding Protein 2X from Streptococcus Pneumoniae and its Acyl-Enzyme Form: Implication in Drug Resistance
J.Mol.Biol., 299, 2000
1RP5
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PBP2X FROM STREPTOCOCCUS PNEUMONIAE STRAIN 5259 WITH REDUCED SUSCEPTIBILITY TO BETA-LACTAM ANTIBIOTICS
Descriptor:penicillin-binding protein 2x, SULFATE ION
Authors:Pernot, L., Chesnel, L., Legouellec, A., Croize, J., Vernet, T., Dideberg, O., Dessen, A.
Deposit date:2003-12-03
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A PBP2x from a clinical isolate of Streptococcus pneumoniae exhibits an alternative mechanism for reduction of susceptibility to beta-lactam antibiotics.
J.Biol.Chem., 279, 2004
2Z2L
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PENICILLIN-BINDING PROTEIN 2X (PBP2X) FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:Penicillin-binding protein 2X, SULFATE ION
Authors:Yamada, M., Watanabe, T., Takeuchi, Y.
Deposit date:2007-05-23
Release date:2007-09-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal Structure of Cefditoren Complexed with Streptococcus pneumoniae Penicillin-Binding Protein 2X: Structural Basis for its High Antimicrobial Activity
Antimicrob.Agents Chemother., 51, 2007
2Z2M
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CEFDITOREN-ACYLATED PENICILLIN-BINDING PROTEIN 2X (PBP2X) FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:Penicillin-binding protein 2X, SULFATE ION, (2R)-2-[(1R)-1-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}-2-OXOETHYL]-5-[(Z)-2-(4-METHYL-1,3-THIAZOL-5-YL)VINYL]-3,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC ACID
Authors:Yamada, M., Watanabe, T., Takeuchi, Y.
Deposit date:2007-05-23
Release date:2007-09-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Cefditoren Complexed with Streptococcus pneumoniae Penicillin-Binding Protein 2X: Structural Basis for its High Antimicrobial Activity
Antimicrob.Agents Chemother., 51, 2007
2ZC3
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PENICILLIN-BINDING PROTEIN 2X (PBP 2X) ACYL-ENZYME COMPLEX (BIAPENEM) FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:Penicillin-binding protein 2X, (4R,5S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylate, SULFATE ION
Authors:Yamada, M., Watanabe, T., Takeuchi, Y.
Deposit date:2007-11-02
Release date:2008-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae
Antimicrob.Agents Chemother., 52, 2008
2ZC4
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PENICILLIN-BINDING PROTEIN 2X (PBP 2X) ACYL-ENZYME COMPLEX (TEBIPENEM) FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:Penicillin-binding protein 2X, (4R,5S)-3-(1-(4,5-dihydrothiazol-2-yl)azetidin-3-ylthio)-5-((2S,3R)-3-hydroxy-1-oxobutan-2-yl)-4-methyl-4,5- dihydro-1H-pyrrole-2-carboxylic acid, SULFATE ION
Authors:Yamada, M., Watanabe, T., Takeuchi, Y.
Deposit date:2007-11-02
Release date:2008-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae
Antimicrob.Agents Chemother., 52, 2008
5OAU
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PENICILLIN-BINDING PROTEIN 2X (PBP2X) FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:Penicillin-binding protein 2X
Authors:Bernardo-Garcia, N., Hermoso, J.A.
Deposit date:2017-06-23
Release date:2018-05-30
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae.
ACS Chem. Biol., 13, 2018
5OIZ
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PENICILLIN-BINDING PROTEIN 2X (PBP2X) FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH OXACILLIN
Descriptor:Penicillin-binding protein 2X, (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carboxylic acid
Authors:Bernardo-Garcia, N., Hermoso, J.A.
Deposit date:2017-07-20
Release date:2018-05-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae.
ACS Chem. Biol., 13, 2018
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