1PYY
Double mutant PBP2x T338A/M339F from Streptococcus pneumoniae strain R6 at 2.4 A resolution
Summary for 1PYY
Entry DOI | 10.2210/pdb1pyy/pdb |
Related | 1K25 1PMD 1QME 1QMF |
Related PRD ID | PRD_900045 |
Descriptor | Penicillin-binding protein 2X, 6-O-octanoyl-beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, SULFATE ION, ... (5 entities in total) |
Functional Keywords | penicillin-binding protein, antibiotic resistance, peptidoglycan synthesis, cell wall, transmembrane, transpeptidase |
Biological source | Streptococcus pneumoniae |
Cellular location | Cell membrane; Single-pass membrane protein: P59676 |
Total number of polymer chains | 1 |
Total formula weight | 77476.65 |
Authors | Chesnel, L.,Pernot, L.,Lemaire, D.,Champelovier, D.,Croize, J.,Dideberg, O.,Vernet, T.,Zapun, A. (deposition date: 2003-07-09, release date: 2003-09-30, Last modification date: 2023-08-16) |
Primary citation | Chesnel, L.,Pernot, L.,Lemaire, D.,Champelovier, D.,Croize, J.,Dideberg, O.,Vernet, T.,Zapun, A. The Structural Modifications Induced by the M339F Substitution in PBP2x from Streptococcus pneumoniae Further Decreases the Susceptibility to beta-Lactams of Resistant Strains J.Biol.Chem., 278:44448-44456, 2003 Cited by PubMed: 12923202DOI: 10.1074/jbc.M305948200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.42 Å) |
Structure validation
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