1RP5
PBP2x from Streptococcus pneumoniae strain 5259 with reduced susceptibility to beta-lactam antibiotics
Summary for 1RP5
| Entry DOI | 10.2210/pdb1rp5/pdb |
| Related | 1K25 1PMD 1PYY 1QME 1QMF |
| Descriptor | penicillin-binding protein 2x, SULFATE ION (3 entities in total) |
| Functional Keywords | penicillin-binding protein, transpeptidase, antibiotic resistance, peptidoglycan synthesis, cell wall, transmembrane |
| Biological source | Streptococcus pneumoniae |
| Cellular location | Cell membrane; Single-pass membrane protein: P14677 |
| Total number of polymer chains | 2 |
| Total formula weight | 154004.19 |
| Authors | Pernot, L.,Chesnel, L.,Legouellec, A.,Croize, J.,Vernet, T.,Dideberg, O.,Dessen, A. (deposition date: 2003-12-03, release date: 2004-02-03, Last modification date: 2023-08-23) |
| Primary citation | Pernot, L.,Chesnel, L.,Le Gouellec, A.,Croize, J.,Vernet, T.,Dideberg, O.,Dessen, A. A PBP2x from a clinical isolate of Streptococcus pneumoniae exhibits an alternative mechanism for reduction of susceptibility to beta-lactam antibiotics. J.Biol.Chem., 279:16463-16470, 2004 Cited by PubMed: 14734544DOI: 10.1074/jbc.M313492200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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