1A4H | |
1AH6 | |
1AH8 | |
1AJ6 | |
1AM1 | |
1AMW | |
1BGQ | |
1BXD | | NMR STRUCTURE OF THE HISTIDINE KINASE DOMAIN OF THE E. COLI OSMOSENSOR ENVZ | | Descriptor: | PROTEIN (OSMOLARITY SENSOR PROTEIN (ENVZ)), PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Tanaka, T., Saha, S.K., Tomomori, C., Ishima, R., Liu, D., Tong, K.I., Park, H., Dutta, R., Qin, L., Swindells, M.B., Yamazaki, T., Ono, A.M., Kainosho, M., Inouye, M., Ikura, M. | | Deposit date: | 1998-10-02 | | Release date: | 1999-10-02 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ.
Nature, 396, 1998
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1BYQ | | HSP90 N-TERMINAL DOMAIN BOUND TO ADP-MG | | Descriptor: | PROTEIN (HEAT SHOCK PROTEIN 90), MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE | | Authors: | Russo, A.A., Pavletich, N.P. | | Deposit date: | 1998-10-19 | | Release date: | 1998-10-28 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis.
J.Cell Biol., 143, 1998
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1ID0 | | CRYSTAL STRUCTURE OF THE NUCLEOTIDE BOND CONFORMATION OF PHOQ KINASE DOMAIN | | Descriptor: | PHOQ HISTIDINE KINASE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Marina, A., Mott, C., Auyzenberg, A., Waldburger, C.D., Hendrickson, W.A. | | Deposit date: | 2001-04-02 | | Release date: | 2001-10-17 | | Last modified: | 2017-02-01 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural and mutational analysis of the PhoQ histidine kinase catalytic domain. Insight into the reaction mechanism.
J.Biol.Chem., 276, 2001
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1KZN | | CRYSTAL STRUCTURE OF E. COLI 24KDA DOMAIN IN COMPLEX WITH CLOROBIOCIN | | Descriptor: | DNA GYRASE SUBUNIT B, CLOROBIOCIN | | Authors: | Lafitte, D., Lamour, V., Tsvetkov, P.O., Makarov, A.A., Klich, M., Deprez, P., Moras, D., Briand, C., Gilli, R. | | Deposit date: | 2002-02-07 | | Release date: | 2002-06-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose.
Biochemistry, 41, 2002
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1OSF | | HUMAN HSP90 IN COMPLEX WITH 17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDANAMYCIN | | Descriptor: | heat shock 90kDa protein 1, alpha; heat shock 90kD protein 1, alpha, ... | | Authors: | Jez, J.M., Chen, J.C.-H., Rastelli, G., Stroud, R.M., Santi, D.V. | | Deposit date: | 2003-03-19 | | Release date: | 2003-05-27 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal Structure and Molecular Modeling of 17-DMAG in Complex with Human Hsp90
Chem.Biol., 10, 2003
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1QY8 | | CRYSTAL STRUCTURE OF THE N-DOMAIN OF THE ER HSP90 CHAPERONE GRP94 IN COMPLEX WITH RADICICOL | | Descriptor: | Endoplasmin, RADICICOL | | Authors: | Soldano, K.L., Jivan, A., Nicchitta, C.V., Gewirth, D.T. | | Deposit date: | 2003-09-09 | | Release date: | 2003-11-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation
J.Biol.Chem., 278, 2003
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1QYE | | CRYSTAL STRUCTURE OF THE N-DOMAIN OF THE ER HSP90 CHAPERONE GRP94 IN COMPLEX WITH 2-CHLORODIDEOXYADENOSINE | | Descriptor: | Endoplasmin, 2-CHLORODIDEOXYADENOSINE, 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE | | Authors: | Soldano, K.L., Jivan, A., Nicchitta, C.V., Gewirth, D.T. | | Deposit date: | 2003-09-10 | | Release date: | 2003-11-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of the N-terminal Domain of GRP94. Basis for Ligand Specificity and Regulation
J.Biol.Chem., 278, 2003
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1R62 | | CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE TWO-COMPONENT SYSTEM TRANSMITTER PROTEIN NRII (NTRB) | | Descriptor: | Nitrogen regulation protein NR(II) | | Authors: | Song, Y., Peisach, D., Pioszak, A.A., Xu, Z., Ninfa, A.J. | | Deposit date: | 2003-10-14 | | Release date: | 2004-06-15 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal Structure of the C-terminal Domain of the Two-Component System Transmitter Protein Nitrogen Regulator II (NRII; NtrB), Regulator of Nitrogen Assimilation in Escherichia coli.
Biochemistry, 43, 2004
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1S14 | | CRYSTAL STRUCTURE OF ESCHERICHIA COLI TOPOISOMERASE IV PARE 24KDA SUBUNIT | | Descriptor: | Topoisomerase IV subunit B, NOVOBIOCIN | | Authors: | Wei, Y., Gross, C.H. | | Deposit date: | 2004-01-05 | | Release date: | 2004-05-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Antimicrob.Agents Chemother., 48, 2004
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1TBW | | LIGAND INDUCED CONFORMATIONAL SHIFT IN THE N-TERMINAL DOMAIN OF GRP94, OPEN CONFORMATION | | Descriptor: | Endoplasmin, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE, ... | | Authors: | Gewirth, D.T., Immormino, R.M., Dollins, D.E., Shaffer, P.L., Walker, M.A., Soldano, K.L. | | Deposit date: | 2004-05-20 | | Release date: | 2004-08-24 | | Last modified: | 2017-08-09 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
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1TC0 | | LIGAND INDUCED CONFORMATIONAL SHIFTS IN THE N-TERMINAL DOMAIN OF GRP94, OPEN CONFORMATION COMPLEXED WITH THE PHYSIOLOGICAL PARTNER ATP | | Descriptor: | Endoplasmin, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Gewirth, D.T., Immormino, R.M., Dollins, D.E., Shaffer, P.L., Walker, M.A., Soldano, K.L. | | Deposit date: | 2004-05-20 | | Release date: | 2004-08-24 | | Last modified: | 2017-08-09 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
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1TC6 | | LIGAND INDUCED CONFORMATIONAL SHIFT IN THE N-TERMINAL DOMAIN OF GRP94, OPEN CONFORMATION ADP-COMPLEX | | Descriptor: | Endoplasmin, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Gewirth, D.T., Immormino, R.M., Dollins, D.E., Shaffer, P.L., Walker, M.A., Soldano, K.L. | | Deposit date: | 2004-05-20 | | Release date: | 2004-08-24 | | Last modified: | 2017-08-09 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone.
J.Biol.Chem., 279, 2004
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1U0Z | |
1U2O | | CRYSTAL STRUCTURE OF THE N-DOMAIN OF GRP94 LACKING THE CHARGED DOMAIN IN COMPLEX WITH NECA | | Descriptor: | Endoplasmin, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, TETRAETHYLENE GLYCOL, ... | | Authors: | Soldano, K.L., Jivan, A., Nicchitta, C.V., Gewirth, D.T. | | Deposit date: | 2004-07-19 | | Release date: | 2004-08-03 | | Last modified: | 2017-08-23 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation
J.Biol.Chem., 278, 2003
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1UY6 | | HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(3,4,5-TRIMETHOXY-BENZYL)-9H-PURIN-6-YLAMINE | | Descriptor: | HEAT SHOCK PROTEIN HSP 90-ALPHA, 9-BUTYL-8-(3,4,5-TRIMETHOXYBENZYL)-9H-PURIN-6-AMINE | | Authors: | Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E. | | Deposit date: | 2004-03-02 | | Release date: | 2004-07-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
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1UY7 | | HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(4-METHOXY-BENZYL)-9H-PURIN-6-YLAMINE | | Descriptor: | HEAT SHOCK PROTEIN HSP 90-ALPHA, 9-BUTYL-8-(4-METHOXYBENZYL)-9H-PURIN-6-AMINE | | Authors: | Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E. | | Deposit date: | 2004-03-02 | | Release date: | 2004-07-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
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1UY8 | | HUMAN HSP90-ALPHA WITH 9-BUTYL-8-(3-TRIMETHOXY-BENZYL)-9H-PURIN-6YLAMINE | | Descriptor: | HEAT SHOCK PROTEIN HSP 90-ALPHA, 9-BUTYL-8-(3-METHOXYBENZYL)-9H-PURIN-6-AMINE | | Authors: | Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E. | | Deposit date: | 2004-03-02 | | Release date: | 2004-07-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
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1UY9 | | HUMAN HSP90-ALPHA WITH 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H-PURIN-6-YLAMINE | | Descriptor: | HEAT SHOCK PROTEIN HSP 90-ALPHA, 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H- | | Authors: | Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., Hubbard, R.E. | | Deposit date: | 2004-03-02 | | Release date: | 2004-07-01 | | Last modified: | 2017-07-05 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure-Activity Relationships in Purine-Based Inhibitor Binding to Hsp90 Isoforms
Chem.Biol., 11, 2004
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