8BN6

Pseudomonas aeruginosa DNA gyrase B 24kDa ATPase subdomain complexed with EBL3021

Summary for 8BN6

• Entry DOI: 10.2210/pdb8bn6/pdb
• Descriptor: DNA gyrase subunit B, CALCIUM ION, 2-[[3,4-bis(chloranyl)-5-methyl-1~{H}-pyrrol-2-yl]carbonylamino]-4-morpholin-4-yl-1,3-benzothiazole-6-carboxylic acid, ... (4 entities in total)
• Functional Keywords: dna gyrase, gyrb, inhibitor, antibacterial, isomerase, dna binding protein
• Biological source: Pseudomonas aeruginosa PAO1
• Total number of polymer chains: 1
• Total formula weight: 25072.91

Authors

Durcik, M.,Zega, A.,Zidar, N.,Ilas, J.,Tomasic, T.,Masic, L.P.,Mundy, J.E.A.,Stevenson, C.E.M.,Burton, N.,Lawson, D.M.,Maxwell, A.,Kikelj, D. (deposition date: 2022-11-12, release date: 2023-03-29, Last modification date: 2024-02-07)

• Primary citation: Durcik, M.,Cotman, A.E.,Toplak, Z.,Mozina, S.,Skok, Z.,Szili, P.E.,Czikkely, M.,Maharramov, E.,Vu, T.H.,Piras, M.V.,Zidar, N.,Ilas, J.,Zega, A.,Trontelj, J.,Pardo, L.A.,Hughes, D.,Huseby, D.,Berruga-Fernandez, T.,Cao, S.,Simoff, I.,Svensson, R.,Korol, S.V.,Jin, Z.,Vicente, F.,Ramos, M.C.,Mundy, J.E.A.,Maxwell, A.,Stevenson, C.E.M.,Lawson, D.M.,Glinghammar, B.,Sjostrom, E.,Bohlin, M.,Oreskar, J.,Alver, S.,Janssen, G.V.,Sterk, G.J.,Kikelj, D.,Pal, C.,Tomasic, T.,Peterlin Masic, L.; New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus .; J.Med.Chem., 66:3968-3994, 2023; PubMed: 36877255; DOI: 10.1021/acs.jmedchem.2c01905

Experimental method

X-RAY DIFFRACTION (1.6 Å)