Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5WW0
DownloadVisualize
BU of 5ww0 by Molmil
Crystal structure of Set7, a novel histone methyltransferase in Schizossacharomyces pombe
Descriptor: SET domain-containing protein 7, SULFATE ION
Authors:Mevius, D.E.H.F, Shen, Y, Morishita, M, Carrozzini, B, Caliandro, R, di Luccio, E.
Deposit date:2016-12-30
Release date:2017-12-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Set7 Is a H3K37 Methyltransferase in Schizosaccharomyces pombe and Is Required for Proper Gametogenesis.
Structure, 27, 2019
6FND
DownloadVisualize
BU of 6fnd by Molmil
Crystal structure of Toxoplasma gondii AKMT
Descriptor: 1,2-ETHANEDIOL, Apical complex lysine methyltransferase, DI(HYDROXYETHYL)ETHER, ...
Authors:Pivovarova, Y, Dong, G.
Deposit date:2018-02-02
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Structure of a Novel Dimeric SET Domain Methyltransferase that Regulates Cell Motility.
J. Mol. Biol., 430, 2018
3KMT
DownloadVisualize
BU of 3kmt by Molmil
Crystal structure of vSET/SAH/H3 ternary complex
Descriptor: A612L protein, Histone H3, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Wei, H, Zhou, M.M.
Deposit date:2009-11-11
Release date:2010-11-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Dimerization of a viral SET protein endows its function.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KMJ
DownloadVisualize
BU of 3kmj by Molmil
Crystal structure of vSET under condition B
Descriptor: A612L protein, SULFATE ION
Authors:Wei, H, Zhou, M.M.
Deposit date:2009-11-10
Release date:2010-11-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Dimerization of a viral SET protein endows its function.
Proc.Natl.Acad.Sci.USA, 107, 2010
2BQZ
DownloadVisualize
BU of 2bqz by Molmil
Crystal structure of a ternary complex of the human histone methyltransferase Pr-SET7 (also known as SET8)
Descriptor: HISTONE H4, S-ADENOSYL-L-HOMOCYSTEINE, SET8 PROTEIN
Authors:Xiao, B, Jing, C, Kelly, G, Walker, P.A, Muskett, F.W, Frenkiel, T.A, Martin, S.R, Sarma, K, Reinberg, D, Gamblin, S.J, Wilson, J.R.
Deposit date:2005-04-28
Release date:2005-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Specificity and Mechanism of the Histone Methyltransferase Pr-Set7
Genes Dev., 19, 2005
4AU7
DownloadVisualize
BU of 4au7 by Molmil
The structure of the Suv4-20h2 ternary complex with histone H4
Descriptor: 1,2-ETHANEDIOL, HISTONE H4 PEPTIDE, HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H2, ...
Authors:Southall, S.M, Cronin, N.B, Wilson, J.R.
Deposit date:2012-05-14
Release date:2013-05-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases.
Nucleic Acids Res., 42, 2014
4BUP
DownloadVisualize
BU of 4bup by Molmil
A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases
Descriptor: GLYCEROL, HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1, S-ADENOSYLMETHIONINE, ...
Authors:Southall, S.M, Cronin, N.B, Wilson, J.R.
Deposit date:2013-06-21
Release date:2013-10-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.166 Å)
Cite:A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases.
Nucleic Acids Res., 42, 2014
2G46
DownloadVisualize
BU of 2g46 by Molmil
structure of vSET in complex with meK27 H3 Pept. and cofactor product SAH
Descriptor: PBCV-1 histone H3-Lys 27 methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, meK27 H3 Peptide
Authors:Qian, C.M, Zheng, L, Zhou, M.M.
Deposit date:2006-02-21
Release date:2006-12-05
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structural insights of the specificity and catalysis of a viral histone H3 lysine 27 methyltransferase.
J.Mol.Biol., 359, 2006
1ZKK
DownloadVisualize
BU of 1zkk by Molmil
Crystal structure of hSET8 in ternary complex with H4 peptide (16-24) and AdoHcy
Descriptor: Histone-lysine N-methyltransferase, H4 lysine-20 specific, Peptide corresponding to residues 15-24 of histone H4, ...
Authors:Couture, J.-F, Collazo, E, Brunzelle, J.S, Trievel, R.C.
Deposit date:2005-05-03
Release date:2005-06-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase
Genes Dev., 19, 2005
4RZ0
DownloadVisualize
BU of 4rz0 by Molmil
Crystal Structure of Plasmodium falciparum putative histone methyltransferase PFL0690c
Descriptor: PFL0690c, UNKNOWN ATOM OR ION
Authors:Jiang, D.Q, Tempel, W, Loppnau, P, Graslund, S, He, H, Ravichandran, M, Seitova, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, Lin, Y.H, Structural Genomics Consortium (SGC)
Deposit date:2014-12-17
Release date:2015-01-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.487 Å)
Cite:Crystal Structure of Plasmodium falciparum putative histone methyltransferase PFL0690c
To be Published
2W5Z
DownloadVisualize
BU of 2w5z by Molmil
Ternary Complex of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and histone peptide.
Descriptor: GLYCEROL, HISTONE PEPTIDE, HISTONE-LYSINE N-METHYLTRANSFERASE HRX, ...
Authors:Southall, S.M, Wong, P.S, Odho, Z, Roe, S.M, Wilson, J.R.
Deposit date:2008-12-15
Release date:2009-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.
Mol.Cell, 33, 2009
2W5Y
DownloadVisualize
BU of 2w5y by Molmil
Binary Complex of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine.
Descriptor: HISTONE-LYSINE N-METHYLTRANSFERASE HRX, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION
Authors:Southall, S.M, Wong, P.S, Odho, Z, Roe, S.M, WIlson, J.R.
Deposit date:2008-12-15
Release date:2009-02-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.
Mol.Cell, 33, 2009
5T5G
DownloadVisualize
BU of 5t5g by Molmil
human SETD8 in complex with MS2177
Descriptor: 7-(2-aminoethoxy)-6-methoxy-2-(pyrrolidin-1-yl)-N-[5-(pyrrolidin-1-yl)pentyl]quinazolin-4-amine, N-lysine methyltransferase KMT5A, UNKNOWN ATOM OR ION
Authors:Yu, W, Tempel, W, Babault, N, Ma, A, Butler, K.V, Jin, J, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2016-08-30
Release date:2016-09-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
J. Med. Chem., 59, 2016
5TEG
DownloadVisualize
BU of 5teg by Molmil
Crystal structure of hSETD8 in complex with histone H4K20 norleucine mutant peptide and S-Adenosylmethionine
Descriptor: Histone H4 mutant peptide with H4K20norleucine, N-lysine methyltransferase KMT5A, S-ADENOSYLMETHIONINE
Authors:Judge, R.A, Petros, A.M.
Deposit date:2016-09-21
Release date:2016-12-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.
ACS Med Chem Lett, 7, 2016
4O30
DownloadVisualize
BU of 4o30 by Molmil
Crystal structure of ATXR5 in complex with histone H3.1 and AdoHcy
Descriptor: BETA-MERCAPTOETHANOL, DIMETHYL SULFOXIDE, Histone-lysine N-methyltransferase ATXR6, ...
Authors:Bergamin, E, Mongeon, V, Couture, J.F.
Deposit date:2013-12-17
Release date:2014-03-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication.
Science, 343, 2014
7U5V
DownloadVisualize
BU of 7u5v by Molmil
Crystal structure of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and Borealin peptide
Descriptor: Borealin, Histone-lysine N-methyltransferase 2A, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:An, S, Cho, U.S, Oh, H, Sha, L, Xu, J, Kim, S, Yang, W, An, W, Dou, Y.
Deposit date:2022-03-02
Release date:2023-09-27
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Non-canonical MLL1 activity regulates centromeric phase separation and genome stability.
Nat.Cell Biol., 25, 2023
3EP0
DownloadVisualize
BU of 3ep0 by Molmil
Methyltransferase domain of human PR domain-containing protein 12
Descriptor: PR domain zinc finger protein 12
Authors:Amaya, M.F, Zeng, H, Loppnau, P, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Botchkarev, A, Min, J, Plotnikov, A.N, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2008-09-29
Release date:2008-11-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of methyltransferase domain of human PR Domain-containing protein 12.
To be Published
3F9W
DownloadVisualize
BU of 3f9w by Molmil
Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20 / AdoHcy
Descriptor: Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C.
Deposit date:2008-11-14
Release date:2008-11-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural origins for the product specificity of SET domain protein methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3F9Y
DownloadVisualize
BU of 3f9y by Molmil
Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20me1 / AdoHcy
Descriptor: Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C.
Deposit date:2008-11-14
Release date:2008-11-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural origins for the product specificity of SET domain protein methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3F9X
DownloadVisualize
BU of 3f9x by Molmil
Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20me2 / AdoHcy
Descriptor: Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C.
Deposit date:2008-11-14
Release date:2008-11-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural origins for the product specificity of SET domain protein methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3F9Z
DownloadVisualize
BU of 3f9z by Molmil
Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y245F / H4-Lys20 / AdoHcy
Descriptor: Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C.
Deposit date:2008-11-14
Release date:2008-11-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural origins for the product specificity of SET domain protein methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
5H6Z
DownloadVisualize
BU of 5h6z by Molmil
Crystal structure of Set7, a novel histone methyltransferase in Schizossacharomyces pombe
Descriptor: AMMONIUM ION, DI(HYDROXYETHYL)ETHER, SET domain-containing protein 7, ...
Authors:Mevius, D.E.H.F, Shen, Y, Morishita, M, Carrozzini, B, Caliandro, R, di Luccio, E.
Deposit date:2016-11-15
Release date:2017-11-22
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Set7 Is a H3K37 Methyltransferase in Schizosaccharomyces pombe and Is Required for Proper Gametogenesis.
Structure, 27, 2019
5HT6
DownloadVisualize
BU of 5ht6 by Molmil
Crystal structure of the SET domain of the human MLL5 methyltransferase
Descriptor: Histone-lysine N-methyltransferase 2E
Authors:le Maire, A, Mas-y-Mas, S, Dumas, C, Lebedev, A.
Deposit date:2016-01-26
Release date:2016-11-16
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.093 Å)
Cite:The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity.
Plos One, 11, 2016
6U9K
DownloadVisualize
BU of 6u9k by Molmil
MLL1 SET N3861I/Q3867L bound to inhibitor 18 (TC-5153)
Descriptor: 5'-([(3S)-3-amino-3-carboxypropyl]{[1-(3,3-diphenylpropyl)azetidin-3-yl]methyl}amino)-5'-deoxyadenosine, GLYCEROL, Histone-lysine N-methyltransferase, ...
Authors:Petrunak, E.M, Stuckey, J.A.
Deposit date:2019-09-09
Release date:2020-07-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.
Acs Med.Chem.Lett., 11, 2020
6U9N
DownloadVisualize
BU of 6u9n by Molmil
MLL1 SET N3861I/Q3867L bound to inhibitor 14 (TC-5139)
Descriptor: 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(4-chlorophenyl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, Histone-lysine N-methyltransferase, ZINC ION
Authors:Petrunak, E.M, Stuckey, J.A.
Deposit date:2019-09-09
Release date:2020-07-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.
Acs Med.Chem.Lett., 11, 2020

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon