7U5V

Crystal structure of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and Borealin peptide

Summary for 7U5V

• Entry DOI: 10.2210/pdb7u5v/pdb
• Descriptor: Histone-lysine N-methyltransferase 2A, Borealin, ZINC ION, ... (4 entities in total)
• Functional Keywords: mll1-set, borealin, histone methyltransferase, non-histone substrate, gene regulation
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 19542.93

Authors

An, S.,Cho, U.S.,Oh, H.,Sha, L.,Xu, J.,Kim, S.,Yang, W.,An, W.,Dou, Y. (deposition date: 2022-03-02, release date: 2023-09-27, Last modification date: 2024-04-10)

• Primary citation: Sha, L.,Yang, Z.,An, S.,Yang, W.,Kim, S.,Oh, H.,Xu, J.,Yin, J.,Wang, H.,Lenz, H.J.,An, W.,Cho, U.S.,Dou, Y.; Non-canonical MLL1 activity regulates centromeric phase separation and genome stability.; Nat.Cell Biol., 25:1637-1649, 2023; PubMed: 37945831; DOI: 10.1038/s41556-023-01270-1

Experimental method

X-RAY DIFFRACTION (2.59 Å)