7U5V
Crystal structure of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and Borealin peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase 2A | polymer | 159 | 18002.8 | 1 | UniProt (Q03164) Pfam (PF00856) | Homo sapiens (human) | Lysine N-methyltransferase 2A,ALL-1,CXXC-type zinc finger protein 7,Myeloid/lymphoid or mixed-lineage leukemia,Myeloid/lymphoid or mixed-lineage leukemia protein 1,Trithorax-like protein,Zinc finger protein HRX |
| 2 | B (C) | Borealin | polymer | 9 | 1090.3 | 1 | UniProt (Q53HL2) | Homo sapiens | Cell division cycle-associated protein 8,Dasra-B,hDasra-B,Pluripotent embryonic stem cell-related gene 3 protein |
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) |
Sequence modifications
A: 3811 - 3969 (UniProt: Q03164)
| PDB | External Database | Details |
|---|---|---|
| Ala 3822 | His 3822 | conflict |
| Ala 3824 | Lys 3824 | conflict |
| Ala 3825 | Lys 3825 | conflict |
| Ala 3826 | Thr 3826 | conflict |
| Ala 3828 | Lys 3828 | conflict |
| Ala 3829 | Glu 3829 | conflict |
| Ala 3945 | Lys 3945 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 19093.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 449.8 | |
| All* | Total formula weight | 19542.9 |
