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9CMI	Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin, sFab COP-1, and Nanobody Descriptor: Anti-Fab Nanobody, COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, ... Authors: Vecchio, A.J. Deposit date: 2024-07-15 Release date: 2024-08-07 Method: ELECTRON MICROSCOPY (2.83 Å) Cite: Cryo-EM Structures of Clostridium perfringens Enterotoxin Bound to its Human Receptor, Claudin-4 To Be Published
9CMH	Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin Descriptor: Claudin-4, Heat-labile enterotoxin B chain Authors: Vecchio, A.J. Deposit date: 2024-07-15 Release date: 2024-07-24 Method: ELECTRON MICROSCOPY (4 Å) Cite: Cryo-EM Structures of Clostridium perfringens Enterotoxin Bound to its Human Receptor, Claudin-4 To Be Published
9B6A	GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of LBD-TMD-TARPgamma2 Descriptor: Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Nakagawa, T, Greger, I.H. Deposit date: 2024-03-23 Release date: 2024-07-31 Last modified: 2024-09-04 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 2024
9B67	GluA2 flip Q in complex with TARPgamma2 at pH8, class1, structure of LBD-TMD-TARPgamma2 Descriptor: Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Nakagawa, T, Greger, I.H. Deposit date: 2024-03-23 Release date: 2024-07-31 Last modified: 2024-09-04 Method: ELECTRON MICROSCOPY (3.39 Å) Cite: Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 2024
9B64	GluA2 flip Q in complex with TARPgamma2 at pH5, class23, structure of LBD-TMD-TARPgamma2 Descriptor: Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Nakagawa, T, Greger, I.H. Deposit date: 2024-03-23 Release date: 2024-07-31 Last modified: 2024-09-04 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 2024
9B63	GluA2 flip Q in complex with TARPgamma2 at pH5, consensus structure of TMD-TARPgamma2 Descriptor: Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Nakagawa, T, Greger, I.H. Deposit date: 2024-03-23 Release date: 2024-07-31 Last modified: 2024-09-04 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 2024
9B61	GluA2 flip Q in complex with TARPgamma2 at pH5, consensus structure of LBD-TMD-TARPgamma2 Descriptor: Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Nakagawa, T, Greger, I.H. Deposit date: 2024-03-23 Release date: 2024-07-31 Last modified: 2024-09-04 Method: ELECTRON MICROSCOPY (2.81 Å) Cite: Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 2024
9B60	GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of TMD-TARPgamma2 Descriptor: Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Nakagawa, T, Greger, I.H. Deposit date: 2024-03-23 Release date: 2024-07-31 Last modified: 2024-09-04 Method: ELECTRON MICROSCOPY (2.57 Å) Cite: Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 2024
9B5Z	GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of LBD-TMD-TARPgamma2 Descriptor: Isoform Flip of Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Nakagawa, T, Greger, I.H. Deposit date: 2024-03-23 Release date: 2024-07-31 Last modified: 2024-09-04 Method: ELECTRON MICROSCOPY (2.71 Å) Cite: Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 2024
8U5B	Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain and sFab COP-1 Descriptor: COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, Claudin-4, ... Authors: Vecchio, A.J. Deposit date: 2023-09-12 Release date: 2023-09-27 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (5.3 Å) Cite: Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment. Commun Biol, 7, 2024
8U4V	Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-1, and Nanobody Descriptor: Anti-fab nanobody, COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, ... Authors: Vecchio, A.J. Deposit date: 2023-09-11 Release date: 2023-10-25 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (2.99 Å) Cite: Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment. Commun Biol, 7, 2024
8PIV	Homomeric GluA2 flip R/G-unedited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 1 Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor, ... Authors: Zhang, D, Krieger, J.M, Yamashita, K, Greger, I.H. Deposit date: 2023-06-22 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (3.46 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8P3Z	Homomeric GluA2 flip R/G-edited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 2 Descriptor: Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Krieger, J.M, Zhang, D, Yamashita, K, Greger, I.H. Deposit date: 2023-05-18 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (3.46 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8P3Y	Homomeric GluA2 flip R/G-edited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 3 Descriptor: Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Krieger, J.M, Zhang, D, Yamashita, K, Greger, I.H. Deposit date: 2023-05-18 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (3.55 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8P3X	Homomeric GluA2 flip R/G-edited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 1 Descriptor: Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Krieger, J.M, Zhang, D, Yamashita, K, Greger, I.H. Deposit date: 2023-05-18 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (3.36 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8P3W	Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 4 Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ... Authors: Zhang, D, Krieger, J.M, Yamashita, K, Greger, I. Deposit date: 2023-05-18 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (3.53 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8P3V	Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 3 Descriptor: Glutamate receptor 1 flip isoform, Voltage-dependent calcium channel gamma-3 subunit Authors: Zhang, D, Krieger, J.M, Yamashita, K, Greger, I.H. Deposit date: 2023-05-18 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (3.53 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8P3U	Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 2 Descriptor: Glutamate receptor 1 flip isoform, Voltage-dependent calcium channel gamma-3 subunit Authors: Zhang, D, Krieger, J.M, Greger, I.H. Deposit date: 2023-05-18 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (3.77 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8P3T	Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 1 Descriptor: Glutamate receptor 1 flip isoform, Voltage-dependent calcium channel gamma-3 subunit Authors: Zhang, D, Krieger, J, Yamashita, K, Greger, I. Deposit date: 2023-05-18 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (3.39 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8P3S	Homomeric GluA2 flip R/G-unedited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 2 Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ... Authors: Zhang, D, Krieger, J.M, Yamashita, K, Greger, I. Deposit date: 2023-05-18 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (2.95 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8P3Q	Homomeric GluA2 flip R/G-unedited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 3 Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ... Authors: Zhang, D, Krieger, J.M, Yamashita, K, Greger, I. Deposit date: 2023-05-18 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (2.95 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8FQF	GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 150mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na260) Descriptor: CHLORIDE ION, Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Nakagawa, T. Deposit date: 2023-01-06 Release date: 2024-02-28 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (2.29 Å) Cite: The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
8FQB	GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 10mM CaCl2, 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Ca10) Descriptor: CALCIUM ION, CHLORIDE ION, Glutamate receptor 2, ... Authors: Nakagawa, T. Deposit date: 2023-01-05 Release date: 2024-02-28 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (2.36 Å) Cite: The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
8FQ5	GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Na110) Descriptor: CHLORIDE ION, Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Nakagawa, T. Deposit date: 2023-01-05 Release date: 2024-02-28 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (2.34 Å) Cite: The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
8FQ1	GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 150mM CaCl2, 330uM CTZ, and 100mM L-glutamate (Open-Ca150) Descriptor: CALCIUM ION, Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit Authors: Nakagawa, T. Deposit date: 2023-01-05 Release date: 2024-02-28 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (5.59 Å) Cite: The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024

 

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