1AMO
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THREE-DIMENSIONAL STRUCTURE OF NADPH-CYTOCHROME P450 REDUCTASE: PROTOTYPE FOR FMN-AND FAD-CONTAINING ENZYMES
Descriptor:NADPH-CYTOCHROME P450 REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, ...
Authors:Wang, M., Roberts, D.L., Paschke, R., Shea, T.M., Masters, B.S.S., Kim, J.J.P.
Deposit date:1997-06-17
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes.
Proc.Natl.Acad.Sci.USA, 94, 1997
1DDG
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CRYSTAL STRUCTURE OF SIR-FP60
Descriptor:SULFITE REDUCTASE (NADPH) FLAVOPROTEIN ALPHA-COMPONENT, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION
Authors:Gruez, A., Pignol, D., Zeghouf, M., Coves, J., Fontecave, M., Ferrer, J.L., Fontecilla-Camps, J.C.
Deposit date:1999-11-10
Release date:2000-11-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module.
J.Mol.Biol., 299, 2000
1DDI
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CRYSTAL STRUCTURE OF SIR-FP60
Descriptor:SULFITE REDUCTASE [NADPH] FLAVOPROTEIN ALPHA-COMPONENT, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Gruez, A., Pignol, D., Zeghouf, M., Coves, J., Fontecave, M., Ferrer, J.L., Fontecilla-Camps, J.C.
Deposit date:1999-11-10
Release date:2000-11-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module.
J.Mol.Biol., 299, 2000
1F20
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CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE FAD/NADP+ DOMAIN AT 1.9A RESOLUTION.
Descriptor:NITRIC-OXIDE SYNTHASE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Zhang, J., Martasek, P., Masters, B.S., Kim, J.P.
Deposit date:2000-05-22
Release date:2001-10-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the FAD/NADPH-binding domain of rat neuronal nitric-oxide synthase. Comparisons with NADPH-cytochrome P450 oxidoreductase.
J.Biol.Chem., 276, 2001
1J9Z
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CYPOR-W677G
Descriptor:NADPH-Cytochrome P450 reductase, FLAVIN-ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, ...
Authors:Hubbard, P.A., Shen, A.L., Paschke, R., Kasper, C.B., Kim, J.J.
Deposit date:2001-05-29
Release date:2001-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer.
J.Biol.Chem., 276, 2001
1JA0
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CYPOR-W677X
Descriptor:NADPH-Cytochrome P450 Reductase, FLAVIN-ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, ...
Authors:Hubbard, P.A., Shen, A.L., Paschke, R., Kasper, C.B., Kim, J.J.
Deposit date:2001-05-29
Release date:2001-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer.
J.Biol.Chem., 276, 2001
1JA1
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CYPOR-TRIPLE MUTANT
Descriptor:NADPH-Cytochrome P450 Reductase, FLAVIN-ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, ...
Authors:Hubbard, P.A., Shen, A.L., Paschke, R., Kasper, C.B., Kim, J.J.
Deposit date:2001-05-29
Release date:2001-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer.
J.Biol.Chem., 276, 2001
1TLL
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CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE REDUCTASE MODULE AT 2.3 A RESOLUTION.
Descriptor:Nitric-oxide synthase, brain, SULFITE ION, ...
Authors:Garcin, E.D., Bruns, C.M., Lloyd, S.J., Hosfield, D.J., Tiso, M., Gachhui, R., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2004-06-09
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase
J.Biol.Chem., 279, 2004
2BF4
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A SECOND FMN-BINDING SITE IN YEAST NADPH-CYTOCHROME P450 REDUCTASE SUGGESTS A NOVEL MECHANISM OF ELECTRON TRANSFER BY DIFLAVIN REDUCTASES.
Descriptor:NADPH-CYTOCHROME P450 REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, ...
Authors:Podust, L.M., Lepesheva, G.I., Kim, Y., Yermalitskaya, L.V., Yermalitsky, V.N., Lamb, D.C., Kelly, S.L., Waterman, M.R.
Deposit date:2004-12-03
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A Second Fmn-Binding Site in Yeast Nadph-Cytochrome P450 Reductase Suggests a Mechanism of Electron Transfer by Diflavin Reductases.
Structure, 14, 2006
2BN4
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A SECOND FMN-BINDING SITE IN YEAST NADPH-CYTOCHROME P450 REDUCTASE SUGGESTS A NOVEL MECHANISM OF ELECTRON TRANSFER BY DIFLAVIN REDUCTASE
Descriptor:NADPH CYTOCHROME P450 REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, ...
Authors:Podust, L.M., Lepesheva, G.I., Kim, Y., Yermalitskaya, L.V., Yermalitsky, V.N., Lamb, D.C., Kelly, S.L., Waterman, M.R.
Deposit date:2005-03-18
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:A Second Fmn-Binding Site in Yeast Nadph-Cytochrome P450 Reductase Suggests a Mechanism of Electron Transfer by Diflavin Reductases.
Structure, 14, 2006
2BPO
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CRYSTAL STRUCTURE OF THE YEAST CPR TRIPLE MUTANT: D74G, Y75F, K78A.
Descriptor:NADPH-CYTOCHROM P450 REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, ...
Authors:Yermalitskaya, L.V., Kim, Y., Waterman, M.R., Podust, L.M.
Deposit date:2005-04-21
Release date:2006-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of the Yeast Cpr Triple Mutant: D74G, Y75F, K78A.
To be Published
2QTL
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CRYSTAL STRUCTURE OF THE FAD-CONTAINING FNR-LIKE MODULE OF HUMAN METHIONINE SYNTHASE REDUCTASE
Descriptor:Methionine synthase reductase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Wolthers, K.R., Lou, X., Toogood, H.S., Leys, D., Scrutton, N.S.
Deposit date:2007-08-02
Release date:2007-11-13
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanism of Coenzyme Binding to Human Methionine Synthase Reductase Revealed through the Crystal Structure of the FNR-like Module and Isothermal Titration Calorimetry
Biochemistry, 46, 2007
2QTZ
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CRYSTAL STRUCTURE OF THE NADP+-BOUND FAD-CONTAINING FNR-LIKE MODULE OF HUMAN METHIONINE SYNTHASE REDUCTASE
Descriptor:Methionine synthase reductase, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Wolthers, K.R., Lou, X., Toogood, H.S., Leys, D., Scrutton, N.S.
Deposit date:2007-08-02
Release date:2007-11-13
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanism of Coenzyme Binding to Human Methionine Synthase Reductase Revealed through the Crystal Structure of the FNR-like Module and Isothermal Titration Calorimetry
Biochemistry, 46, 2007
3ES9
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NADPH-CYTOCHROME P450 REDUCTASE IN AN OPEN CONFORMATION
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Hamdane, D., Xia, C., Im, S.-C., Zhang, H., Kim, J.-J., Waskell, L.
Deposit date:2008-10-05
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450
J.Biol.Chem., 284, 2009
3FJO
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STRUCTURE OF CHIMERIC YH CPR
Descriptor:NADPH-cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Morera, S., Aigrain, L., Truan, G.
Deposit date:2008-12-15
Release date:2009-06-16
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the open conformation of a functional chimeric NADPH cytochrome P450 reductase
Embo Rep., 10, 2009
3OJW
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DISULFIDE CROSSLINKED CYTOCHROME P450 REDUCTASE INACTIVE
Descriptor:NADPH-cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Xia, C., Hamdane, D., Shen, A., Choi, V., Kasper, C., Zhang, H., Im, S.-C., Waskell, L., Kim, J.-J.P.
Deposit date:2010-08-23
Release date:2011-02-23
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding.
J.Biol.Chem., 286, 2011
3OJX
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DISULFIDE CROSSLINKED CYTOCHROME P450 REDUCTASE INACTIVE
Descriptor:NADPH-Cytochrome P450 Reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Hamdane, D., Shen, A., Choi, V., Kasper, C., Zhang, H., Im, S.-C., Waskell, L., Kim, J.-J.P.
Deposit date:2010-08-23
Release date:2011-02-23
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding.
J.Biol.Chem., 286, 2011
3QE2
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CRYSTAL STRUCTURE OF HUMAN NADPH-CYTOCHROME P450 REDUCTASE
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN-ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, ...
Authors:Xia, C., Marohnic, C., Panda, S.P., Masters, B.S., Kim, J.-J.P.
Deposit date:2011-01-19
Release date:2011-08-03
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency.
Proc.Natl.Acad.Sci.USA, 108, 2011
3QFC
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CRYSTAL STRUCTURE OF HUMAN NADPH-CYTOCHROME P450 (V492E MUTANT)
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN-ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, ...
Authors:Xia, C., Marohnic, C., Panda, S.P., Masters, B.S., Kim, J.-J.P.
Deposit date:2011-01-21
Release date:2011-08-03
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency.
Proc.Natl.Acad.Sci.USA, 108, 2011
3QFR
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CRYSTAL STRUCTURE OF HUMAN NADPH-CYTOCHROME P450 REDUCTASE (R457H MUTANT)
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN-ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, ...
Authors:Xia, C., Marohnic, C., Panda, S.P., Masters, B.S., Kim, J.-J.P.
Deposit date:2011-01-22
Release date:2011-08-03
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency.
Proc.Natl.Acad.Sci.USA, 108, 2011
3QFS
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CRYSTAL STRUCTURE OF NADPH-CYTOCHROME P450 REDUCTASE (FAD/NADPH DOMAIN)
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Xia, C., Marohnic, C., Panda, S.P., Masters, B.S., Kim, J.-J.P.
Deposit date:2011-01-22
Release date:2011-08-17
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency.
Proc.Natl.Acad.Sci.USA, 108, 2011
3QFT
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CRYSTAL STRUCTURE OF NADPH-CYTOCHROME P450 REDUCTASE (FAD/NADPH DOMAIN AND R457H MUTANT)
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Xia, C., Marohnic, C., Panda, S.P., Masters, B.S., Kim, J.-J.P.
Deposit date:2011-01-22
Release date:2011-08-17
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency.
Proc.Natl.Acad.Sci.USA, 108, 2011
3WKT
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COMPLEX STRUCTURE OF AN OPEN FORM OF NADPH-CYTOCHROME P450 REDUCTASE AND HEME OXYGENASE-1
Descriptor:NADPH-cytochrome P450 reductase, Heme oxygenase 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Sugishima, M., Sato, H., Higashimoto, Y., Harada, J., Wada, K., Fukuyama, K., Noguchi, M.
Deposit date:2013-10-31
Release date:2014-01-29
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Structural basis for the electron transfer from an open form of NADPH-cytochrome P450 oxidoreductase to heme oxygenase.
Proc.Natl.Acad.Sci.USA, 111, 2014
4Y7C
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RAT CYPOR MUTANT - G141DEL/E142N
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.P.
Deposit date:2015-02-13
Release date:2016-02-24
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone.
J.Biol.Chem., 291, 2016
4Y9R
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RAT CYPOR MUTANT - G141DEL
Descriptor:NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Kim, J.J.P.
Deposit date:2015-02-17
Release date:2016-03-02
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone.
J.Biol.Chem., 291, 2016
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