2QTL
Crystal Structure of the FAD-containing FNR-like Module of Human Methionine Synthase Reductase
Summary for 2QTL
Entry DOI | 10.2210/pdb2qtl/pdb |
Related | 2QTZ |
Descriptor | Methionine synthase reductase, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total) |
Functional Keywords | alpha-beta-alpha structural motif, flattened antiparallel beta barrel, flexible hinge region, connecting domain, fad-binding region, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Isoform B: Cytoplasm. Isoform C: Cytoplasm. Isoform A: Cytoplasm : Q9UBK8 |
Total number of polymer chains | 1 |
Total formula weight | 60858.07 |
Authors | Wolthers, K.R.,Lou, X.,Toogood, H.S.,Leys, D.,Scrutton, N.S. (deposition date: 2007-08-02, release date: 2007-11-13, Last modification date: 2022-12-21) |
Primary citation | Wolthers, K.R.,Lou, X.,Toogood, H.S.,Leys, D.,Scrutton, N.S. Mechanism of Coenzyme Binding to Human Methionine Synthase Reductase Revealed through the Crystal Structure of the FNR-like Module and Isothermal Titration Calorimetry Biochemistry, 46:11833-11844, 2007 Cited by PubMed: 17892308DOI: 10.1021/bi701209p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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