1CP3 | |
1F1J | |
1GQF | |
1I4E | | CRYSTAL STRUCTURE OF THE CASPASE-8/P35 COMPLEX | | Descriptor: | Early 35 kDa protein, Caspase-8 | | Authors: | Xu, G., Cirilli, M., Huang, Y., Rich, R.L., Myszka, D.G., Wu, H. | | Deposit date: | 2001-02-20 | | Release date: | 2001-03-28 | | Last modified: | 2013-09-25 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex.
Nature, 410, 2001
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1JXQ | | STRUCTURE OF CLEAVED, CARD DOMAIN DELETED CASPASE-9 | | Descriptor: | Caspase-9, benzoxycarbonyl-Val-Ala-Asp-fluoromethyl ketone Inhibitor | | Authors: | Renatus, M., Stennicke, H.R., Scott, F.L., Liddington, R.C., Salvesen, G.S. | | Deposit date: | 2001-09-08 | | Release date: | 2001-12-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Dimer formation drives the activation of the cell death protease caspase 9.
Proc.Natl.Acad.Sci.USA, 98, 2001
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1K86 | | CRYSTAL STRUCTURE OF CASPASE-7 | | Descriptor: | caspase-7 | | Authors: | Chai, J., Wu, Q., Shiozaki, E., Srinivasa, S.M., Alnemri, E.S., Shi, Y. | | Deposit date: | 2001-10-23 | | Release date: | 2001-11-21 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding
Cell(Cambridge,Mass.), 107, 2001
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1K88 | | CRYSTAL STRUCTURE OF PROCASPASE-7 | | Descriptor: | procaspase-7 | | Authors: | Chai, J., Wu, Q., Shiozaki, E., Srinivasa, S.M., Alnemri, E.S., Shi, Y. | | Deposit date: | 2001-10-23 | | Release date: | 2001-11-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding
Cell(Cambridge,Mass.), 107, 2001
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1M72 | | CRYSTAL STRUCTURE OF CASPASE-1 FROM SPODOPTERA FRUGIPERDA | | Descriptor: | Caspase-1, Ace-Asp-Glu-Val-Asp-chloromethylketone, 1,2-ETHANEDIOL | | Authors: | Forsyth, C.M., Lemongello, D., Friesen, P.D., Fisher, A.J. | | Deposit date: | 2002-07-18 | | Release date: | 2004-01-20 | | Last modified: | 2013-02-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of an invertebrate caspase.
J.Biol.Chem., 279, 2004
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1NMQ | | EXTENDEND TETHERING: IN SITU ASSEMBLY OF INHIBITORS | | Descriptor: | Caspase-3, 3-(3-{2-[(5-METHANESULFONYL-THIOPHENE-2-CARBONYL)-AMINO]-ETHYLDISULFANYLMETHYL}- BENZENESULFONYLAMINO)-4-OXO-PENTANOIC ACID | | Authors: | Erlanson, D.A., Lam, J., Wiesmann, C., Luong, T.N., Simmons, R.L., DeLano, W., Choong, I.C., Flanagan, M., Lee, D., O'Brian, T. | | Deposit date: | 2003-01-10 | | Release date: | 2003-03-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | In situ assembly of enzyme inhibitors using extended tethering.
Nat.Biotechnol., 21, 2003
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1NMS | | CASPASE-3 TETHERED TO IRREVERSIBLE INHIBITOR | | Descriptor: | Caspase-3, 5-[4-(1-CARBOXYMETHYL-2-OXO-PROPYLCARBAMOYL)-BENZYLSULFAMOYL]-2-HYDROXY-BENZOIC ACID | | Authors: | Erlanson, D.A., Lam, J., Wiesmann, C., Luong, T.N., Simmons, R.L., DeLano, W.L., Choong, I.C., Flanagan, W.M., Lee, D., O'Brian, T. | | Deposit date: | 2003-01-10 | | Release date: | 2003-03-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | In situ assembly of enzyme inhibitors using extended tethering.
Nat.Biotechnol., 21, 2003
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1QX3 | | CONFORMATIONAL RESTRICTIONS IN THE ACTIVE SITE OF UNLIGANDED HUMAN CASPASE-3 | | Descriptor: | Apopain | | Authors: | Ni, C.-Z., Li, C., Wu, J.C., Spada, A.P., Ely, K.R. | | Deposit date: | 2003-09-04 | | Release date: | 2003-10-07 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Conformational restrictions in the active site of unliganded human caspase-3
J.MOL.RECOG., 16, 2003
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1SHJ | | CASPASE-7 IN COMPLEX WITH DICA ALLOSTERIC INHIBITOR | | Descriptor: | Caspase-7, SULFATE ION, 2-(2,4-DICHLORO-PHENOXY)-N-(2-MERCAPTO-ETHYL)-ACETAMIDE | | Authors: | Hardy, J.A., Lam, J., Nguyen, J.T., O'Brien, T., Wells, J.A. | | Deposit date: | 2004-02-25 | | Release date: | 2004-08-17 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Discovery of an allosteric site in the caspases
Proc.Natl.Acad.Sci.USA, 101, 2004
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1SHL | | CASPASE-7 IN COMPLEX WITH FICA ALLOSTERIC INHIBITOR | | Descriptor: | Caspase-7, 5-FLUORO-1H-INDOLE-2-CARBOXYLIC ACID-(2-MERCAPTO-ETHYL)-AMIDE | | Authors: | Hardy, J.A., Lam, J., Nguyen, J.T., O'Brien, T., Wells, J.A. | | Deposit date: | 2004-02-25 | | Release date: | 2004-08-17 | | Last modified: | 2017-08-23 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Discovery of an allosteric site in the caspases
Proc.Natl.Acad.Sci.USA, 101, 2004
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2AR9 | | CRYSTAL STRUCTURE OF A DIMERIC CASPASE-9 | | Descriptor: | Caspase-9, D-MALATE | | Authors: | Chao, Y., Shiozaki, E.N., Srinivassula, S.M., Rigotti, D.J., Fairman, R., Shi, Y. | | Deposit date: | 2005-08-19 | | Release date: | 2005-10-11 | | Last modified: | 2012-02-15 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Engineering a Dimeric Caspase-9: A Re-Evaluation of the Induced Proximity Model for Caspase Activation
PLOS BIOL., 3, 2005
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2FP3 | |
2FUN | | ALTERNATIVE P35-CASPASE-8 COMPLEX | | Descriptor: | Early 35 kDa protein, caspase-8 | | Authors: | Lu, M., Min, T., Eliezer, D., Wu, H. | | Deposit date: | 2006-01-27 | | Release date: | 2006-06-27 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Native chemical ligation in covalent caspase inhibition by p35.
Chem.Biol., 13, 2006
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2J30 | | THE ROLE OF LOOP BUNDLE HYDROGEN BONDS IN THE MATURATION AND ACTIVITY OF (PRO)CASPASE-3 | | Descriptor: | CASPASE-3, ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR | | Authors: | Feeney, B., Pop, C., Swartz, P., Mattos, C., Clark, A.C. | | Deposit date: | 2006-08-17 | | Release date: | 2006-11-08 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of (Pro)Caspase-3.
Biochemistry, 45, 2006
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2J31 | | THE ROLE OF LOOP BUNDLE HYDROGEN BONDS IN THE MATURATION AND ACTIVITY OF(PRO)CASPASE-3 | | Descriptor: | CASPASE-3, ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR | | Authors: | Feeney, B., Pop, C., Swartz, P., Mattos, C., Clark, A.C. | | Deposit date: | 2006-08-17 | | Release date: | 2006-11-08 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of (Pro)Caspase-3.
Biochemistry, 45, 2006
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2J32 | | THE ROLE OF LOOP BUNDLE HYDROGEN BONDS IN THE MATURATION AND ACTIVITY OF(PRO)CASPASE-3 | | Descriptor: | CASPASE-3, ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR | | Authors: | Feeney, B., Pop, C., Swartz, P., Mattos, C., Clark, A.C. | | Deposit date: | 2006-08-17 | | Release date: | 2006-11-08 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of (Pro)Caspase-3.
Biochemistry, 45, 2006
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2J33 | | THE ROLE OF LOOP BUNDLE HYDROGEN BONDS IN THE MATURATION AND ACTIVITY OF (PRO)CASPASE-3 | | Descriptor: | CASPASE-3, ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR | | Authors: | Feeney, B., Pop, C., Swartz, P., Mattos, C., Clark, A.C. | | Deposit date: | 2006-08-17 | | Release date: | 2006-11-08 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of (Pro)Caspase-3.
Biochemistry, 45, 2006
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2K7Z | |
2NN3 | | STRUCTURE OF PRO-SF-CASPASE-1 | | Descriptor: | Caspase-1 | | Authors: | Fisher, A.J., Ni, L. | | Deposit date: | 2006-10-23 | | Release date: | 2007-10-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Pro-sfcapsase-1, structural insights into activation mechanism of caspases
To be Published
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2WDP | | CRYSTAL STRUCTURE OF LIGAND FREE HUMAN CASPASE-6 | | Descriptor: | CASPASE-6, PHOSPHATE ION | | Authors: | Baumgartner, R., Briand, C., Meder, G., Morse, R., Renatus, M. | | Deposit date: | 2009-03-25 | | Release date: | 2009-10-27 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | The Crystal Structure of Caspase-6, a Selective Effector of Axonal Degeneration.
Biochem.J., 423, 2009
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3BIJ | | CRYSTAL STRUCTURE OF PROTEIN GSU0716 FROM GEOBACTER SULFURREDUCENS. NORTHEAST STRUCTURAL GENOMICS TARGET GSR13 | | Descriptor: | Uncharacterized protein GSU0716 | | Authors: | Forouhar, F., Neely, H., Su, M., Seetharaman, J., Benach, J., Conover, K., Fang, Y., Xiao, R., Owen, L.A., Maglaqui, M., Cunningham, K., Baran, M.C., Acton, T.B., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-11-30 | | Release date: | 2007-12-11 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of protein GSU0716 from Geobacter sulfurreducens.
To be Published
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3DEH | | CRYSTAL STRUCTURES OF CASPASE-3 WITH BOUND ISOQUINOLINE-1,3,4-TRIONE DERIVATIVE INHIBITORS | | Descriptor: | Caspase-3, isoquinoline-1,3,4(2H)-trione | | Authors: | Wu, J., Du, J., Li, J., Ding, J. | | Deposit date: | 2008-06-10 | | Release date: | 2008-09-02 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species
J.Biol.Chem., 283, 2008
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