1DDV
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CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH BOUND MGLUR PEPTIDE
Descriptor:GLGF-DOMAIN PROTEIN HOMER, METABOTROPIC GLUTAMATE RECEPTOR MGLUR5
Authors:Beneken, J., Tu, J.C., Xiao, B., Worley, P.F., Leahy, D.J.
Deposit date:1999-11-11
Release date:2000-05-10
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition.
Neuron, 26, 2000
1DDW
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HOMER EVH1 DOMAIN UNLIGANDED
Descriptor:GLGF-DOMAIN PROTEIN HOMER
Authors:Beneken, J., Tu, J.C., Xiao, B., Worley, P.F., Leahy, D.J.
Deposit date:1999-11-11
Release date:2000-05-10
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition.
Neuron, 26, 2000
1EGX
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SOLUTION STRUCTURE OF THE ENA-VASP HOMOLOGY 1 (EVH1) DOMAIN OF HUMAN VASODILATOR-STIMULATED PHOSPHOPROTEIN (VASP)
Descriptor:VASODILATOR-STIMULATED PHOSPHOPROTEIN
Authors:Ball, L., Kuhne, R., Hoffmann, B., Hafner, A., Schmieder, P., Volkmer-Engert, R., Hof, M., Wahl, M., Schneider-Mergener, J., Walter, U., Oschkinat, H., Jarchau, T.
Deposit date:2000-02-17
Release date:2000-09-20
Last modified:2012-07-25
Method:SOLUTION NMR
Cite:Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity.
EMBO J., 19, 2000
1EVH
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EVH1 DOMAIN FROM MURINE ENABLED IN COMPLEX WITH ACTA PEPTIDE
Descriptor:PROTEIN (MENA EVH1 DOMAIN), Peptide ACTA
Authors:Prehoda, K.E., Lee, D.J., Lim, W.A.
Deposit date:1999-04-21
Release date:1999-05-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly.
Cell(Cambridge,Mass.), 97, 1999
1I2H
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CRYSTAL STRUCTURE ANALYSIS OF PSD-ZIP45(HOMER1C/VESL-1L)CONSERVED HOMER 1 DOMAIN
Descriptor:PSD-ZIP45(HOMER-1C/VESL-1L)
Authors:Irie, K., Nakatsu, T., Mitsuoka, K., Fujiyoshi, Y., Kato, H.
Deposit date:2001-02-09
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Homer 1 Family Conserved Region Reveals the Interaction Between the EVH1 Domain and Own Proline-rich Motif
J.Mol.Biol., 318, 2002
1I7A
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EVH1 DOMAIN FROM MURINE HOMER 2B/VESL 2
Descriptor:HOMER 2B, PHE-ALA-PHE, CITRATE ANION, ...
Authors:Barzik, M., Carl, U.D., Schubert, W.-D., Wehland, J., Heinz, D.W.
Deposit date:2001-03-08
Release date:2001-08-22
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:The N-terminal domain of Homer/Vesl is a new class II EVH1 domain.
J.Mol.Biol., 309, 2001
1MKE
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STRUCTURE OF THE N-WASP EVH1 DOMAIN-WIP COMPLEX
Descriptor:Fusion protein consisting of Wiskott-Aldrich syndrome protein interacting protein (WIP), GSGSG linker, and Neural Wiskott-Aldrich syndrome protein (N-WASP)
Authors:Volkman, B.F., Prehoda, K.E., Scott, J.A., Peterson, F.C., Lim, W.A.
Deposit date:2002-08-29
Release date:2002-12-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the N-WASP EVH1 Domain-WIP Complex. Insight into the Molecular Basis of Wiskott-Aldrich Syndrome.
Cell(Cambridge,Mass.), 111, 2002
1QC6
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EVH1 DOMAIN FROM ENA/VASP-LIKE PROTEIN IN COMPLEX WITH ACTA PEPTIDE
Descriptor:EVH1 DOMAIN FROM ENA/VASP-LIKE PROTEIN, PHE-GLU-PHE-PRO-PRO-PRO-PRO-THR-ASP-GLU-GLU
Authors:Fedorov, A.A., Fedorov, E.V., Gertler, F.B., Almo, S.C.
Deposit date:1999-05-17
Release date:1999-05-25
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function
Nat.Struct.Biol., 6, 1999
1TJ6
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CRYSTAL STRUCTURE OF THE XENOPUS TROPICALIS SPRED1 EVH-1 DOMAIN
Descriptor:Spred1
Authors:Harmer, N.J., Sivak, J., Amaya, E., Blundell, T.L.
Deposit date:2004-06-03
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:1.65A Crystal structure of the X. tropicalis Spred1 Enabled/Vasodilator-stimulated phosphoprotein homology-1 domain
To be Published
1XOD
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CRYSTAL STRUCTURE OF X. TROPICALIS SPRED1 EVH-1 DOMAIN
Descriptor:Spred1, GLYCEROL
Authors:Harmer, N.J., Sivak, J.M., Amaya, E., Blundell, T.L.
Deposit date:2004-10-06
Release date:2005-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:1.15A Crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family
Febs Lett., 579, 2005
2IFS
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STRUCTURE OF THE N-WASP EVH1 DOMAIN IN COMPLEX WITH AN EXTENDED WIP PEPTIDE
Descriptor:Wiskott-Aldrich Syndrome Protien interacting protein and Neural Wiskott-Aldrich syndrome protein chimera
Authors:Volkman, B.F., Peterson, F.C., Deng, Q.
Deposit date:2006-09-21
Release date:2007-01-16
Last modified:2012-11-14
Method:SOLUTION NMR
Cite:Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP.
J.Biol.Chem., 282, 2007
2IYB
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STRUCTURE OF COMPLEX BETWEEN THE 3RD LIM DOMAIN OF TES AND THE EVH1 DOMAIN OF MENA
Descriptor:PROTEIN ENABLED HOMOLOG, TESTIN, ZINC ION
Authors:Briggs, D.C., McDonald, N.Q.
Deposit date:2006-07-14
Release date:2007-10-16
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding.
Mol. Cell, 28, 2007
2JP2
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SOLUTION STRUCTURE AND RESONANCE ASSIGNMENT OF THE N-TERMINAL EVH1 DOMAIN FROM THE HUMAN SPRED2 PROTEIN (SPROUTY-RELATED PROTEIN WITH EVH1 DOMAIN ISOFORM 2)
Descriptor:Sprouty-related, EVH1 domain-containing protein 2
Authors:Fossi, M., Zimmermann, J., Jarchau, T., Lemak, A., Walter, U., Wiegelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Oschkinat, H., Ball, L.J., Structural Genomics Consortium (SGC)
Deposit date:2007-04-18
Release date:2007-05-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain
J.Biomol.NMR, 29, 2004
4MY6
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ENAH-EVH1 IN COMPLEX WITH PEPTIDOMIMETIC LOW-MOLECULAR WEIGHT INHIBITOR AC-[2-CL-F]-[PROM-2]-[PROM-1]-OH
Descriptor:Protein enabled homolog, (3aR,5aS,8S,10aS)-1-[(3S,6R,8aS)-1'-[(2S)-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8a-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-10-oxidanylidene-2,3,3a,5a,8,10a-hexahydrodipyrrolo[3,2-b:3',1'-f]azepine-8-carboxylic acid, BROMIDE ION
Authors:Barone, M., Roske, Y., Kuehne, R.
Deposit date:2013-09-27
Release date:2014-10-15
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.
Proc.Natl.Acad.Sci.USA, 112, 2015
5N91
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ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-PPPP-OH
Descriptor:Protein enabled homolog, Ac-[2-Cl-F]-PPPP-OH, NITRATE ION
Authors:Barone, M., Roske, Y.
Deposit date:2017-02-24
Release date:2017-06-28
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:ENAH EVH1 in complex with Ac-[2-Cl-F]-PPPP-OH
To be published
5N9C
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ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-PP-[PROM-1]-OH
Descriptor:Protein enabled homolog, Ac-[2-Cl-F]-PP-[ProM-1]-OH, SULFATE ION, ...
Authors:Barone, M., Roske, Y.
Deposit date:2017-02-24
Release date:2017-06-14
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.
Proc. Natl. Acad. Sci. U.S.A., 112, 2015
5N9P
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ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-PP-[PROM-1]-NH2
Descriptor:Protein enabled homolog, Ac-[2-Cl-F]-PP-[ProM-1]-NH2, CHLORIDE ION
Authors:Barone, M., Roske, Y.
Deposit date:2017-02-26
Release date:2017-06-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.
Proc. Natl. Acad. Sci. U.S.A., 112, 2015
5NAJ
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ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-[PROM-1]-[PROM-1]-OH
Descriptor:Protein enabled homolog, (3~{S},7~{R},10~{R},13~{S})-4-[[(3~{S},7~{R},10~{R},13~{S})-4-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-en-13-yl]carbonyl]-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid, SULFATE ION, ...
Authors:Barone, M., Roske, Y.
Deposit date:2017-02-28
Release date:2017-05-24
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-1]-[ProM-1]-OH
To be published
5NBF
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ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-[PROM-2]-[PROM-3]-OH
Descriptor:Protein enabled homolog, (3~{S},6~{S},7~{R},9~{a}~{R})-6-[[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonylamino]-7-methyl-5-oxidanylidene-1,2,3,6,7,9~{a}-hexahydropyrrolo[1,2-a]azepine-3-carboxylic acid, SULFATE ION, ...
Authors:Barone, M., Roske, Y.
Deposit date:2017-03-01
Release date:2017-05-24
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-3]-OH
To be published
5NBX
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ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-PP-[PROM-9]-OH
Descriptor:Protein enabled homolog, BROMIDE ION, 2-chloro-L-phenylalanine, ...
Authors:Barone, M., Roske, Y.
Deposit date:2017-03-02
Release date:2018-03-21
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Ena/VASP as possible antimetastatic target addressed by structure-optimized ProM scaffolds
To be published
5NC2
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ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-PPPPTEDEL-NH2
Descriptor:Protein enabled homolog, Ac-[2-Cl-F]PPPPTEDEL-NH2, SULFATE ION, ...
Authors:Barone, M., Roske, Y.
Deposit date:2017-03-03
Release date:2018-03-21
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Ena/VASP as possible antimetastatic target addressed by structure-optimized ProM scaffolds
To be published
5NC7
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ENAH EVH1 IN COMPLEX WITH AC-WPPPPTEDEL-NH2
Descriptor:Protein enabled homolog, ActA-derived 10-mer Ac-FPPPPTEDEL-NH2 with acetylated (Ac) and amidated (NH2) termini. Phe is substitued by Trp to increase affinity for crystallization
Authors:Barone, M., Roske, Y.
Deposit date:2017-03-03
Release date:2018-03-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ena/VASP as possible antimetastatic target addressed by structure-optimized ProM scaffolds
To be published
5NCF
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ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-[PROM-2]-[PROM-4]-OH
Descriptor:Protein enabled homolog, (1~{S},4~{S},7~{R},10~{R})-14-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-2-oxidanylidene-3,14-diazatricyclo[8.4.0.0^{3,7}]tetradec-8-ene-4-carboxylic acid, SULFATE ION, ...
Authors:Barone, M., Roske, Y.
Deposit date:2017-03-04
Release date:2017-06-14
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.
Proc. Natl. Acad. Sci. U.S.A., 112, 2015
5NCG
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ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-[PROM-2]-[PROM-9]-OH
Descriptor:Protein enabled homolog, (3~{S},7~{R},10~{R},11~{R},13~{S})-4-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-11-methyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid, NITRATE ION
Authors:Barone, M., Roske, Y.
Deposit date:2017-03-04
Release date:2018-03-21
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Ena/VASP as possible antimetastatic target addressed by structure-optimized ProM scaffolds
To be published
5NCP
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ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-[PROM-2]-[PROM-12]-OH
Descriptor:Protein enabled homolog, (3~{S},7~{R},10~{R},13~{R})-4-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid, NITRATE ION, ...
Authors:Barone, M., Roske, Y.
Deposit date:2017-03-06
Release date:2018-03-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Ena/VASP as possible antimetastatic target addressed by structure-optimized ProM scaffolds
To be published
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