6XVT

ENAH EVH1 in complex with Ac-[2-Cl-F]-PPPPTEDDL-NH2

Summary for 6XVT

• Entry DOI: 10.2210/pdb6xvt/pdb
• Related: 5NC2
• Descriptor: Protein enabled homolog, ACY-SC1-SC2-SC3-SC4-SC5-NME, NITRATE ION, ... (5 entities in total)
• Functional Keywords: proline-rich motif, acta, ena/vasp inhibitor, actin, protein-protein interaction, cell adhesion
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 26916.98

Authors

Barone, M.,Le Cong, K.,Roske, Y. (deposition date: 2020-01-22, release date: 2020-03-18, Last modification date: 2024-02-07)

• Primary citation: Barone, M.,Muller, M.,Chiha, S.,Ren, J.,Albat, D.,Soicke, A.,Dohmen, S.,Klein, M.,Bruns, J.,van Dinther, M.,Opitz, R.,Lindemann, P.,Beerbaum, M.,Motzny, K.,Roske, Y.,Schmieder, P.,Volkmer, R.,Nazare, M.,Heinemann, U.,Oschkinat, H.,Ten Dijke, P.,Schmalz, H.G.,Kuhne, R.; Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.; Proc.Natl.Acad.Sci.USA, 117:29684-29690, 2020; PubMed: 33184177; DOI: 10.1073/pnas.2007213117

Experimental method

X-RAY DIFFRACTION (1.4 Å)