6RCJ

ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-15]-OMe

Summary for 6RCJ

• Entry DOI: 10.2210/pdb6rcj/pdb
• Related: 6RCF
• Descriptor: Protein enabled homolog, methyl 2-[(3~{a}~{R},6~{R},8~{a}~{S})-1-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-6-ethyl-8-oxidanylidene-3,3~{a},6,8~{a}-tetrahydro-2~{H}-pyrrolo[2,3-c]azepin-7-yl]ethanoate, NITRATE ION, ... (5 entities in total)
• Functional Keywords: proline-rich motif, ena/vasp inhibitor, actin, protein-protein interaction, cell adhesion
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 13538.59

Authors

Barone, M.,Roske, Y. (deposition date: 2019-04-11, release date: 2020-05-13, Last modification date: 2024-01-31)

• Primary citation: Barone, M.,Muller, M.,Chiha, S.,Ren, J.,Albat, D.,Soicke, A.,Dohmen, S.,Klein, M.,Bruns, J.,van Dinther, M.,Opitz, R.,Lindemann, P.,Beerbaum, M.,Motzny, K.,Roske, Y.,Schmieder, P.,Volkmer, R.,Nazare, M.,Heinemann, U.,Oschkinat, H.,Ten Dijke, P.,Schmalz, H.G.,Kuhne, R.; Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.; Proc.Natl.Acad.Sci.USA, 117:29684-29690, 2020; PubMed: 33184177; DOI: 10.1073/pnas.2007213117

Experimental method

X-RAY DIFFRACTION (1.35 Å)