1F16
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SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX
Descriptor:SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX
Authors:Suzuki, M., Youle, R.J., Tjandra, N.
Deposit date:2000-05-18
Release date:2000-11-22
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Structure of Bax: coregulation of dimer formation and intracellular localization.
Cell(Cambridge,Mass.), 103, 2000
1K3K
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SOLUTION STRUCTURE OF A BCL-2 HOMOLOG FROM KAPOSI'S SARCOMA VIRUS
Descriptor:functional anti-apoptotic factor vBCL-2 homolog
Authors:Huang, Q., Petros, A.M., Virgin, H.W., Fesik, S.W., Olejniczak, E.T.
Deposit date:2001-10-03
Release date:2002-04-10
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus.
Proc.Natl.Acad.Sci.USA, 99, 2002
1Q59
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SOLUTION STRUCTURE OF THE BHRF1 PROTEIN FROM EPSTEIN-BARR VIRUS, A HOMOLOG OF HUMAN BCL-2
Descriptor:Early antigen protein R
Authors:Huang, Q., Petros, A.M., Virgin, H.W., Fesik, S.W., Olejniczak, E.T.
Deposit date:2003-08-06
Release date:2003-09-23
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2
J.Mol.Biol., 332, 2003
1WSX
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SOLUTION STRUCTURE OF MCL-1
Descriptor:myeloid cell leukemia sequence 1
Authors:Day, C.L., Chen, L., Richardson, S.J., Harrison, P.J., Huang, D.C., Hinds, M.G.
Deposit date:2004-11-12
Release date:2004-11-23
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands
J.Biol.Chem., 280, 2005
2IMS
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THE X-RAY STRUCTURE OF A BAK HOMODIMER REVEALS AN INHIBITORY ZINC BINDING SITE
Descriptor:Apoptosis regulator BAK
Authors:Moldoveanu, T., Liu, Q., Tocilj, A., Watson, M., Shore, G.C., Gehring, K.B.
Deposit date:2006-10-04
Release date:2006-12-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:The X-Ray Structure of a BAK Homodimer Reveals an Inhibitory Zinc Binding Site
Mol.Cell, 24, 2006
2IMT
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THE X-RAY STRUCTURE OF A BAK HOMODIMER REVEALS AN INHIBITORY ZINC BINDING SITE
Descriptor:Apoptosis regulator BAK
Authors:Moldoveanu, T., Liu, Q., Tocilj, A., Watson, M., Shore, G.C., Gehring, K.B.
Deposit date:2006-10-04
Release date:2007-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site.
Mol.Cell, 24, 2006
2JCN
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THE CRYSTAL STRUCTURE OF BAK1 - A MITOCHONDRIAL APOPTOSIS REGULATOR
Descriptor:BCL-2 HOMOLOGOUS ANTAGONIST/KILLER
Authors:Moche, M., Stenmark, P., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Edwards, A., Ericsson, U.B., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg Schiavone, L., Johansson, I., Karlberg, T., Kosinska, U., Kotenyova, T., Lundgren, S., Nilsson, M.E., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Uppenberg, J., Upsten, M., Thorsell, A.G., van den Berg, S., Weigelt, J., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2006-12-27
Release date:2007-01-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Crystal Structure of Bak1 - an Apoptosis Trigger in the Mitochondrial Outer Membrane
To be Published
2JM6
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SOLUTION STRUCTURE OF MCL-1 COMPLEXED WITH NOXAB
Descriptor:Noxa, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Authors:Czabotar, P.E., Lee, E.F., van Delft, M.F., Day, C.L., Smith, B.J., Huang, D.C.S., Fairlie, W.D., Hinds, M.G., Colman, P.M.
Deposit date:2006-10-17
Release date:2007-03-20
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Structural insights into the degradation of Mcl-1 induced by BH3 domains
Proc.Natl.Acad.Sci.Usa, 104, 2007
2K7W
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BAX ACTIVATION IS INITIATED AT A NOVEL INTERACTION SITE
Descriptor:Apoptosis regulator BAX, Bcl-2-like protein 11
Authors:Gavathiotis, E., Suzuki, M., Davis, M.L., Pitter, K., Bird, G.H., Katz, S.G., Tu, H.C., Kim, H., Cheng, E.H., Tjandra, N., Walensky, L.D.
Deposit date:2008-08-27
Release date:2008-10-21
Last modified:2009-09-22
Method:SOLUTION NMR
Cite:BAX activation is initiated at a novel interaction site.
Nature, 455, 2008
2KBW
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SOLUTION STRUCTURE OF HUMAN MCL-1 COMPLEXED WITH HUMAN BID_BH3 PEPTIDE
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, BH3-interacting domain death agonist
Authors:Liu, Q., Moldoveanu, T., Sprules, T., Matta-Camacho, E., Mansur-Azzam, N., Gehring, K.
Deposit date:2008-12-09
Release date:2009-12-15
Last modified:2010-06-30
Method:SOLUTION NMR
Cite:Apoptotic regulation by MCL-1 through heterodimerization.
J.Biol.Chem., 285, 2010
2KUA
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SOLUTION STRUCTURE OF A DIVERGENT BCL-2 PROTEIN
Descriptor:Bcl-2-like protein 10
Authors:Rautureau, G.J., Day, C.L., Hinds, M.G.
Deposit date:2010-02-16
Release date:2010-03-23
Last modified:2010-05-19
Method:SOLUTION NMR
Cite:The structure of Boo/Diva reveals a divergent Bcl-2 protein.
Proteins, 78, 2010
2LR1
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STRUCTURAL MECHANISM FOR BAX INHIBITION BY CYTOMEGALOVIRUS PROTEIN VMIA
Descriptor:Apoptosis regulator BAX, Immediate early glycoprotein
Authors:Ma, J.
Deposit date:2012-03-20
Release date:2012-12-05
Last modified:2017-02-22
Method:SOLUTION NMR
Cite:Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA.
Proc.Natl.Acad.Sci.USA, 109, 2012
2M5B
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THE NMR STRUCTURE OF THE BID-BAK COMPLEX
Descriptor:human_cBAK, human_BID_BH3_SAHB
Authors:Moldoveanu, T., Grace, C.R., Kriwacki, R.W., Green, D.R.
Deposit date:2013-02-19
Release date:2013-04-17
Last modified:2013-05-22
Method:SOLUTION NMR
Cite:BID-induced structural changes in BAK promote apoptosis.
Nat.Struct.Mol.Biol., 20, 2013
2MHS
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NMR STRUCTURE OF HUMAN MCL-1
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Liu, G., Poppe, L., Aoki, K., Yamane, H., Lewis, J., Szyperski, T.
Deposit date:2013-12-04
Release date:2014-05-14
Method:SOLUTION NMR
Cite:High-Quality NMR Structure of Human Anti-Apoptotic Protein Domain Mcl-1(171-327) for Cancer Drug Design.
Plos One, 9, 2014
2NL9
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CRYSTAL STRUCTURE OF THE MCL-1:BIM BH3 COMPLEX
Descriptor:FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Bcl-2-like protein 11
Authors:Czabotar, P.E., Colman, P.M.
Deposit date:2006-10-19
Release date:2007-03-27
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural insights into the degradation of Mcl-1 induced by BH3 domains.
Proc.Natl.Acad.Sci.USA, 104, 2007
2NLA
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CRYSTAL STRUCTURE OF THE MCL-1:MNOXAB BH3 COMPLEX
Descriptor:FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, mNoxa BH3
Authors:Czabotar, P.E., Colman, P.M.
Deposit date:2006-10-19
Release date:2007-03-27
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into the degradation of Mcl-1 induced by BH3 domains.
Proc.Natl.Acad.Sci.USA, 104, 2007
2O2F
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-2 IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand
Authors:Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
Deposit date:2006-11-29
Release date:2007-02-27
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O2M
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-X
Authors:Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
Deposit date:2006-11-30
Release date:2007-02-27
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2O2N
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SOLUTION STRUCTURE OF THE ANTI-APOPTOTIC PROTEIN BCL-XL IN COMPLEX WITH AN ACYL-SULFONAMIDE-BASED LIGAND
Descriptor:Apoptosis regulator Bcl-X
Authors:Bruncko, M., Oost, T.K., Belli, B.A., Ding, H., Joseph, M.K., Kunzer, A., Martineau, D., McClellan, W.J., Mitten, M., Ng, S.C., Nimmer, P.M., Oltersdorf, T., Park, C.M., Petros, A.M., Shoemaker, A.R., Song, X., Wang, X., Wendt, M.D., Zhang, H., Fesik, S.W., Rosenberg, S.H., Elmore, S.W.
Deposit date:2006-11-30
Release date:2007-02-27
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL.
J.Med.Chem., 50, 2007
2PQK
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X-RAY CRYSTAL STRUCTURE OF HUMAN MCL-1 IN COMPLEX WITH BIM BH3
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, Bim BH3 peptide
Authors:Bare, E., Grant, R.A., Keating, A.E.
Deposit date:2007-05-02
Release date:2007-06-19
Last modified:2013-04-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.
Protein Sci., 19, 2010
2ROC
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SOLUTION STRUCTURE OF MCL-1 COMPLEXED WITH PUMA
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Bcl-2-binding component 3
Authors:Day, C.L., Smits, C., Fan, F.C., Lee, E.F., Fairlie, W.D., Hinds, M.G.
Deposit date:2008-03-17
Release date:2008-07-08
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1
J.Mol.Biol., 380, 2008
2ROD
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SOLUTION STRUCTURE OF MCL-1 COMPLEXED WITH NOXAA
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Noxa
Authors:Day, C.L., Smits, C., Fan, F.C., Lee, E.F., Fairlie, W.D., Hinds, M.G.
Deposit date:2008-03-17
Release date:2008-07-08
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1
J.Mol.Biol., 380, 2008
2V6Q
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CRYSTAL STRUCTURE OF A BHRF-1 : BIM BH3 COMPLEX
Descriptor:BHRF1 PROTEIN, BCL-2-LIKE PROTEIN 11
Authors:Kvansakul, M., Huang, D.C.S., Colman, P.M.
Deposit date:2007-07-20
Release date:2008-08-19
Last modified:2011-01-19
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus Bhrf1.
Plos Pathog., 6, 2010
2VM6
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HUMAN BCL-2A1 IN COMPLEX WITH BIM
Descriptor:BCL-2-RELATED PROTEIN A1, BCL-2-LIKE PROTEIN 11
Authors:Herman, M.D., Lehtio, L., Arrowsmith, C.H., Berglund, H., Busam, R.D., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Moche, M., Nilsson, M.E., Nyman, T., Persson, C., Sagemark, J., Svensson, L., Thorsell, A.G., Tresaugues, L., van den Berg, S., Weigelt, J., Welin, M., Nordlund, P., Structural Genomics Consortium (SGC)
Deposit date:2008-01-23
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Completing the Family Portrait of the Anti- Apoptotic Bcl-2 Proteins: Crystal Structure of Human Bfl-1 in Complex with Bim.
FEBS Lett., 582, 2008
2VOF
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STRUCTURE OF MOUSE A1 BOUND TO THE PUMA BH3-DOMAIN
Descriptor:BCL-2-RELATED PROTEIN A1, BCL-2-BINDING COMPONENT 3
Authors:Smits, C., Czabotar, P.E., Hinds, M.G., Day, C.L.
Deposit date:2008-02-17
Release date:2008-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1.
Structure, 16, 2008
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