PDB: 121 resultsInfo pagesStatus searchChemie searchBIRD

---

5CIY	Structural basis of the recognition of H3K36me3 by DNMT3B PWWP domain Descriptor: DNA (5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*(3DR)P*GP*CP*AP*TP*GP*G)-3'), Modification methylase HhaI, ... Authors: Rondelet, G, DAL MASO, T, Willems, L, Wouters, J. Deposit date: 2015-07-13 Release date: 2016-03-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.594 Å) Cite: Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B. J.Struct.Biol., 194, 2016
6FDF	Crystal structure of S. pombe Dnmt2 methyltransferase Descriptor: GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (cytosine(38)-C(5))-methyltransferase Authors: Johannsson, S, Neumann, P, Ficner, R. Deposit date: 2017-12-22 Release date: 2018-06-20 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.697 Å) Cite: Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine. Sci Rep, 8, 2018
8C59	CpG specific M.MpeI methyltransferase crystallized in the presence of 5-bromocytosine (converted to 5mC) and 5-methylcytosine containing dsDNA Descriptor: CARBONATE ION, CITRIC ACID, Cytosine-specific methyltransferase, ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Last modified: 2024-09-04 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Cytosine analogues as DNA methyltransferase substrates. Nucleic Acids Res., 52, 2024
2C7P	HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-D(*G*GP*AP*TP*GP*(5CM*2PR)*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*CP*GP*CP*AP*TP*CP*C)-3', ... Authors: Neely, R.K, Daujotyte, D, Grazulis, S, Magennis, S.W, Dryden, D.T.F, Klimasauskas, S, Jones, A.C. Deposit date: 2005-11-25 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
3G7U	Crystal structure of putative DNA modification methyltransferase encoded within prophage Cp-933R (E.coli) Descriptor: CHLORIDE ION, Cytosine-specific methyltransferase, GLYCEROL Authors: Patskovsky, Y, Ramagopal, U.A, Toro, R, Gilmore, M, Iizuka, M, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) Deposit date: 2009-02-10 Release date: 2009-02-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal Structure of DNA Modification Methyltransferase Encoded within Prophage Cp-933R (E.coli) To be Published
6X9J	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3830052 Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*G)-R(P*(PYO))-D(P*GP*GP*CP*CP*TP*C)-3'), ... Authors: Pathuri, S, Horton, J.R, Cheng, X. Deposit date: 2020-06-02 Release date: 2021-07-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021
1G55	Structure of human DNMT2, an enigmatic DNA methyltransferase homologue Descriptor: BETA-MERCAPTOETHANOL, DNA CYTOSINE METHYLTRANSFERASE DNMT2, GLYCEROL, ... Authors: Dong, A, Yoder, J.A, Zhang, X, Zhou, L, Bestor, T.H, Cheng, X. Deposit date: 2000-10-30 Release date: 2001-01-17 Last modified: 2018-06-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. Nucleic Acids Res., 29, 2001
8C58	CpG specific M.MpeI methyltransferase crystallized in the presence of 5-hydroxycytosine and 5-methylcytosine containing dsDNA Descriptor: CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5OC)P*GP*CP*TP*GP*AP*A)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Last modified: 2024-09-04 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Cytosine analogues as DNA methyltransferase substrates. Nucleic Acids Res., 52, 2024
2C7Q	HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine outside the recognition sequence (paired with G) and SAH Descriptor: 5'-D(*T*GP*GP*(2PR)*GP*GP*(5CM)*GP*CP*TP*GP* AP*C)-3', 5'-D(*T*GP*TP*CP*AP*GP*CP*GP*CP*CP*GP*CP*C)-3', CITRIC ACID, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2005-11-27 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes Nucleic Acids Res., 33, 2005
2C7O	HhaI DNA methyltransferase complex with 13mer oligonucleotide containing 2-aminopurine adjacent to the target base (PCGC:GMGC) and SAH Descriptor: 5'-D(*T*GP*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP *C)-3', 5'-D(*T*GP*TP*CP*AP*(2PR)*CP*GP*CP*AP*TP*CP *C)-3', MODIFICATION METHYLASE HHAI, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2005-11-25 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7R	HhaI DNA methyltransferase (T250G mutant) complex with oligonucleotide containing 2-aminopurine as a target base (GPGC:GMGC) and SAH Descriptor: 5'-D(*G*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*(2PR)*GP*CP*AP*TP*CP*C)-3', GLYCEROL, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2005-11-27 Release date: 2005-12-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
5LOD	Crystal structure of HhaI DNA methyltransferase in APO form Descriptor: Modification methylase HhaI, SULFATE ION Authors: Rondelet, G, Wouters, J. Deposit date: 2016-08-09 Release date: 2017-08-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors. Future Med Chem, 9, 2017
3EEO	M. HhaI co-crystallized with synthetic dsDNA containing a propane diol in place of the deoxycytidine residue targeted for methylation. Descriptor: 5'-D(P*DCP*DCP*DAP*DTP*DGP*DCP*DGP*DCP*DTP*DGP*DAP*DC)-3', 5'-D(P*DGP*DTP*DCP*DAP*DGP*(PDI)P*DGP*DCP*DAP*DTP*DGP*DG)-3', Modification methylase HhaI, ... Authors: Porta, J.C, Christman, J.K, Borgstahl, G.E.O. Deposit date: 2008-09-05 Release date: 2010-03-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.94 Å) Cite: M. HhaI co-crystallized with synthetic dsDNA containing a propane diol in place of the deoxycytidine residue targeted for methylation. To be Published
8C57	CpG specific M.MpeI methyltransferase crystallized in the presence of 5,6-dihydro-5-azacytosine (converted to 5m-dhaC) and 5-methylcytosine containing dsDNA Descriptor: CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5MA)P*GP*CP*TP*GP*AP*A)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. Deposit date: 2023-01-06 Release date: 2024-01-17 Last modified: 2024-09-04 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Cytosine analogues as DNA methyltransferase substrates. Nucleic Acids Res., 52, 2024
2HR1	Ternary structure of WT M.HhaI C5-Cytosine DNA methyltransferase with unmodified DNA and AdoHcy Descriptor: 5'-D(*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', 5'-D(*TP*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, ... Authors: Shieh, F. Deposit date: 2006-07-19 Release date: 2006-09-19 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.96 Å) Cite: The Role of Arg165 Towards Base Flipping, Base Stabilization and Catalysis in M.HhaI. J.Mol.Biol., 362, 2006
7SFC	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3735967A Descriptor: 1,2-ETHANEDIOL, DNA (12-MER), DNA (cytosine-5)-methyltransferase 1, ... Authors: Horton, J.R, Pathuri, S, Cheng, X. Deposit date: 2021-10-03 Release date: 2022-03-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
2UYC	HhaI DNA methyltransferase R163N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH Descriptor: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*GP*5CMP*GP*CP*TP *GP*AP*C)-3', GLYCEROL, ... Authors: Daujotyte, D, Grazulis, S. Deposit date: 2007-04-03 Release date: 2008-05-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: HhaI DNA Methyltransferase R163N Mutant Complex with 13mer Gcgc-Gmgc Oligonucleotide and Sah To be Published
7SFF	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3852279B Descriptor: (2R)-2-{[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl}-2-[4-(trifluoromethyl)phenyl]acetamide, 1,2-ETHANEDIOL, DNA (12-MER), ... Authors: Horton, J.R, Pathuri, S, Cheng, X. Deposit date: 2021-10-03 Release date: 2022-03-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
6MHT	TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND DNA CONTAINING 4'-THIO-2'DEOXYCYTIDINE AT THE TARGET Descriptor: CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, DNA (5'-D(P*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*(4SC)P*GP*CP*AP*TP*GP*G)-3'), ... Authors: Cheng, X. Deposit date: 1998-08-05 Release date: 1998-08-12 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.05 Å) Cite: DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase. Nucleic Acids Res., 25, 1997
7SFD	Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3543105A Descriptor: (2S)-2-({3,5-dicyano-4-ethyl-6-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]pyridin-2-yl}sulfanyl)-2-phenylacetamide, 1,2-ETHANEDIOL, DNA (12-MER), ... Authors: Horton, J.R, Pathuri, S, Cheng, X. Deposit date: 2021-10-03 Release date: 2022-03-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure, 30, 2022
5GUT	The crystal structure of mouse DNMT1 (731-1602) mutant - N1248A Descriptor: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... Authors: Chen, S.J, Ye, F. Deposit date: 2016-08-31 Release date: 2017-09-06 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.099 Å) Cite: Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS Chem. Biol., 13, 2018
2UZ4	HhaI DNA methyltransferase R165N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH Descriptor: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*GP*5CMP*GP*CP*TP*GP *AP*C)-3', GLYCEROL, ... Authors: Daujotyte, D, Leinartaite, L, Grazulis, S. Deposit date: 2007-04-25 Release date: 2008-06-03 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: DNA Methyltransferase R165N Mutant To be Published
7L4C	Crystal structure of the DRM2-CTT DNA complex Descriptor: DNA (5'-D(*AP*TP*TP*AP*TP*TP*AP*AP*TP*(C49)P*TP*TP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*AP*AP*GP*AP*TP*TP*AP*AP*TP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... Authors: Fang, J, Song, J. Deposit date: 2020-12-18 Release date: 2021-08-04 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
4DKJ	CpG specific methyltransferase in complex with target DNA Descriptor: Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(C37)P*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*TP*G)-3'), ... Authors: Wojciechowski, M, Czapinska, H, Bochtler, M. Deposit date: 2012-02-03 Release date: 2012-12-05 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: CpG underrepresentation and the bacterial CpG-specific DNA methyltransferase M.MpeI. Proc.Natl.Acad.Sci.USA, 110, 2013
3QV2	Structure Analysis of Entamoeba histolytica methyltransferase EhMeth Descriptor: 5-cytosine DNA methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION Authors: Schulz, E.C, Roth, H.M, Ankri, S, Ficner, R. Deposit date: 2011-02-25 Release date: 2012-04-11 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal Structure Analysis of Entamoeba histolytica Methyltransferase To be Published

 

12345>