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5CIY
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BU of 5ciy by Molmil
Structural basis of the recognition of H3K36me3 by DNMT3B PWWP domain
Descriptor: DNA (5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*(3DR)P*GP*CP*AP*TP*GP*G)-3'), Modification methylase HhaI, ...
Authors:Rondelet, G, DAL MASO, T, Willems, L, Wouters, J.
Deposit date:2015-07-13
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.594 Å)
Cite:Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B.
J.Struct.Biol., 194, 2016
6FDF
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BU of 6fdf by Molmil
Crystal structure of S. pombe Dnmt2 methyltransferase
Descriptor: GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (cytosine(38)-C(5))-methyltransferase
Authors:Johannsson, S, Neumann, P, Ficner, R.
Deposit date:2017-12-22
Release date:2018-06-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.697 Å)
Cite:Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine.
Sci Rep, 8, 2018
8C59
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BU of 8c59 by Molmil
CpG specific M.MpeI methyltransferase crystallized in the presence of 5-bromocytosine (converted to 5mC) and 5-methylcytosine containing dsDNA
Descriptor: CARBONATE ION, CITRIC ACID, Cytosine-specific methyltransferase, ...
Authors:Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M.
Deposit date:2023-01-06
Release date:2024-01-17
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Cytosine analogues as DNA methyltransferase substrates.
Nucleic Acids Res., 52, 2024
2C7P
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BU of 2c7p by Molmil
HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-D(*G*GP*AP*TP*GP*(5CM*2PR)*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*CP*GP*CP*AP*TP*CP*C)-3', ...
Authors:Neely, R.K, Daujotyte, D, Grazulis, S, Magennis, S.W, Dryden, D.T.F, Klimasauskas, S, Jones, A.C.
Deposit date:2005-11-25
Release date:2005-12-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes.
Nucleic Acids Res., 33, 2005
3G7U
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BU of 3g7u by Molmil
Crystal structure of putative DNA modification methyltransferase encoded within prophage Cp-933R (E.coli)
Descriptor: CHLORIDE ION, Cytosine-specific methyltransferase, GLYCEROL
Authors:Patskovsky, Y, Ramagopal, U.A, Toro, R, Gilmore, M, Iizuka, M, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2009-02-10
Release date:2009-02-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of DNA Modification Methyltransferase Encoded within Prophage Cp-933R (E.coli)
To be Published
6X9J
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BU of 6x9j by Molmil
Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3830052
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*G)-R(P*(PYO))-D(P*GP*GP*CP*CP*TP*C)-3'), ...
Authors:Pathuri, S, Horton, J.R, Cheng, X.
Deposit date:2020-06-02
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.
Nat Cancer, 2, 2021
1G55
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BU of 1g55 by Molmil
Structure of human DNMT2, an enigmatic DNA methyltransferase homologue
Descriptor: BETA-MERCAPTOETHANOL, DNA CYTOSINE METHYLTRANSFERASE DNMT2, GLYCEROL, ...
Authors:Dong, A, Yoder, J.A, Zhang, X, Zhou, L, Bestor, T.H, Cheng, X.
Deposit date:2000-10-30
Release date:2001-01-17
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA.
Nucleic Acids Res., 29, 2001
8C58
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BU of 8c58 by Molmil
CpG specific M.MpeI methyltransferase crystallized in the presence of 5-hydroxycytosine and 5-methylcytosine containing dsDNA
Descriptor: CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5OC)P*GP*CP*TP*GP*AP*A)-3'), ...
Authors:Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M.
Deposit date:2023-01-06
Release date:2024-01-17
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Cytosine analogues as DNA methyltransferase substrates.
Nucleic Acids Res., 52, 2024
2C7Q
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BU of 2c7q by Molmil
HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine outside the recognition sequence (paired with G) and SAH
Descriptor: 5'-D(*T*GP*GP*(2PR)*GP*GP*(5CM)*GP*CP*TP*GP* AP*C)-3', 5'-D(*T*GP*TP*CP*AP*GP*CP*GP*CP*CP*GP*CP*C)-3', CITRIC ACID, ...
Authors:Daujotyte, D, Grazulis, S.
Deposit date:2005-11-27
Release date:2005-12-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes
Nucleic Acids Res., 33, 2005
2C7O
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BU of 2c7o by Molmil
HhaI DNA methyltransferase complex with 13mer oligonucleotide containing 2-aminopurine adjacent to the target base (PCGC:GMGC) and SAH
Descriptor: 5'-D(*T*GP*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP *C)-3', 5'-D(*T*GP*TP*CP*AP*(2PR)*CP*GP*CP*AP*TP*CP *C)-3', MODIFICATION METHYLASE HHAI, ...
Authors:Daujotyte, D, Grazulis, S.
Deposit date:2005-11-25
Release date:2005-12-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes.
Nucleic Acids Res., 33, 2005
2C7R
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BU of 2c7r by Molmil
HhaI DNA methyltransferase (T250G mutant) complex with oligonucleotide containing 2-aminopurine as a target base (GPGC:GMGC) and SAH
Descriptor: 5'-D(*G*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*(2PR)*GP*CP*AP*TP*CP*C)-3', GLYCEROL, ...
Authors:Daujotyte, D, Grazulis, S.
Deposit date:2005-11-27
Release date:2005-12-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes.
Nucleic Acids Res., 33, 2005
5LOD
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BU of 5lod by Molmil
Crystal structure of HhaI DNA methyltransferase in APO form
Descriptor: Modification methylase HhaI, SULFATE ION
Authors:Rondelet, G, Wouters, J.
Deposit date:2016-08-09
Release date:2017-08-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors.
Future Med Chem, 9, 2017
3EEO
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BU of 3eeo by Molmil
M. HhaI co-crystallized with synthetic dsDNA containing a propane diol in place of the deoxycytidine residue targeted for methylation.
Descriptor: 5'-D(P*DCP*DCP*DAP*DTP*DGP*DCP*DGP*DCP*DTP*DGP*DAP*DC)-3', 5'-D(P*DGP*DTP*DCP*DAP*DGP*(PDI)P*DGP*DCP*DAP*DTP*DGP*DG)-3', Modification methylase HhaI, ...
Authors:Porta, J.C, Christman, J.K, Borgstahl, G.E.O.
Deposit date:2008-09-05
Release date:2010-03-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:M. HhaI co-crystallized with synthetic dsDNA containing a propane diol in place of the deoxycytidine residue targeted for methylation.
To be Published
8C57
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BU of 8c57 by Molmil
CpG specific M.MpeI methyltransferase crystallized in the presence of 5,6-dihydro-5-azacytosine (converted to 5m-dhaC) and 5-methylcytosine containing dsDNA
Descriptor: CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5MA)P*GP*CP*TP*GP*AP*A)-3'), ...
Authors:Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M.
Deposit date:2023-01-06
Release date:2024-01-17
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Cytosine analogues as DNA methyltransferase substrates.
Nucleic Acids Res., 52, 2024
2HR1
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BU of 2hr1 by Molmil
Ternary structure of WT M.HhaI C5-Cytosine DNA methyltransferase with unmodified DNA and AdoHcy
Descriptor: 5'-D(*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', 5'-D(*TP*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, ...
Authors:Shieh, F.
Deposit date:2006-07-19
Release date:2006-09-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:The Role of Arg165 Towards Base Flipping, Base Stabilization and Catalysis in M.HhaI.
J.Mol.Biol., 362, 2006
7SFC
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BU of 7sfc by Molmil
Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3735967A
Descriptor: 1,2-ETHANEDIOL, DNA (12-MER), DNA (cytosine-5)-methyltransferase 1, ...
Authors:Horton, J.R, Pathuri, S, Cheng, X.
Deposit date:2021-10-03
Release date:2022-03-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors.
Structure, 30, 2022
2UYC
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BU of 2uyc by Molmil
HhaI DNA methyltransferase R163N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH
Descriptor: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*GP*5CMP*GP*CP*TP *GP*AP*C)-3', GLYCEROL, ...
Authors:Daujotyte, D, Grazulis, S.
Deposit date:2007-04-03
Release date:2008-05-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:HhaI DNA Methyltransferase R163N Mutant Complex with 13mer Gcgc-Gmgc Oligonucleotide and Sah
To be Published
7SFF
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BU of 7sff by Molmil
Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3852279B
Descriptor: (2R)-2-{[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl}-2-[4-(trifluoromethyl)phenyl]acetamide, 1,2-ETHANEDIOL, DNA (12-MER), ...
Authors:Horton, J.R, Pathuri, S, Cheng, X.
Deposit date:2021-10-03
Release date:2022-03-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors.
Structure, 30, 2022
6MHT
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BU of 6mht by Molmil
TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND DNA CONTAINING 4'-THIO-2'DEOXYCYTIDINE AT THE TARGET
Descriptor: CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, DNA (5'-D(P*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*(4SC)P*GP*CP*AP*TP*GP*G)-3'), ...
Authors:Cheng, X.
Deposit date:1998-08-05
Release date:1998-08-12
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase.
Nucleic Acids Res., 25, 1997
7SFD
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BU of 7sfd by Molmil
Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3543105A
Descriptor: (2S)-2-({3,5-dicyano-4-ethyl-6-[4-(2-hydroxyethyl)-1,4-diazepan-1-yl]pyridin-2-yl}sulfanyl)-2-phenylacetamide, 1,2-ETHANEDIOL, DNA (12-MER), ...
Authors:Horton, J.R, Pathuri, S, Cheng, X.
Deposit date:2021-10-03
Release date:2022-03-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors.
Structure, 30, 2022
5GUT
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BU of 5gut by Molmil
The crystal structure of mouse DNMT1 (731-1602) mutant - N1248A
Descriptor: DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
Authors:Chen, S.J, Ye, F.
Deposit date:2016-08-31
Release date:2017-09-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1.
ACS Chem. Biol., 13, 2018
2UZ4
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BU of 2uz4 by Molmil
HhaI DNA methyltransferase R165N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH
Descriptor: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*GP*5CMP*GP*CP*TP*GP *AP*C)-3', GLYCEROL, ...
Authors:Daujotyte, D, Leinartaite, L, Grazulis, S.
Deposit date:2007-04-25
Release date:2008-06-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:DNA Methyltransferase R165N Mutant
To be Published
7L4C
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BU of 7l4c by Molmil
Crystal structure of the DRM2-CTT DNA complex
Descriptor: DNA (5'-D(*AP*TP*TP*AP*TP*TP*AP*AP*TP*(C49)P*TP*TP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*AP*AP*GP*AP*TP*TP*AP*AP*TP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ...
Authors:Fang, J, Song, J.
Deposit date:2020-12-18
Release date:2021-08-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Substrate deformation regulates DRM2-mediated DNA methylation in plants.
Sci Adv, 7, 2021
4DKJ
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BU of 4dkj by Molmil
CpG specific methyltransferase in complex with target DNA
Descriptor: Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(C37)P*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*TP*G)-3'), ...
Authors:Wojciechowski, M, Czapinska, H, Bochtler, M.
Deposit date:2012-02-03
Release date:2012-12-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:CpG underrepresentation and the bacterial CpG-specific DNA methyltransferase M.MpeI.
Proc.Natl.Acad.Sci.USA, 110, 2013
3QV2
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BU of 3qv2 by Molmil
Structure Analysis of Entamoeba histolytica methyltransferase EhMeth
Descriptor: 5-cytosine DNA methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION
Authors:Schulz, E.C, Roth, H.M, Ankri, S, Ficner, R.
Deposit date:2011-02-25
Release date:2012-04-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure Analysis of Entamoeba histolytica Methyltransferase
To be Published

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