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8URF
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Crystal Structure of human ASGR2 CRD (Carbohydrate Recognition Domain) bound to 8G8 Fab
Descriptor: 8G8 Fab Heavy Chain, 8G8 Fab Light Chain, Asialoglycoprotein receptor 2, ...
Authors:Sampathumar, P, Li, Y.
Deposit date:2023-10-25
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Targeted protein degradation systems to enhance Wnt signaling.
Elife, 13, 2024
8TS0
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BU of 8ts0 by Molmil
Crystal Structure of human ASGR1 CRD (Carbohydrate Recognition Domain) bound to 8M24 Fab
Descriptor: 8M24 Fab Heavy chain, 8M24 Fab Light chain, Asialoglycoprotein receptor 1, ...
Authors:Sampathkumar, P, Li, Y.
Deposit date:2023-08-10
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Targeted protein degradation systems to enhance Wnt signaling.
Elife, 13, 2024
8OUQ
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BU of 8ouq by Molmil
Clr-11 from Rattus norvegicus
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, C-type lectin domain family 2 member D11
Authors:Skalova, T, Blaha, J, Kalouskova, B, Skorepa, O, Vanek, O, Dohnalek, J.
Deposit date:2023-04-24
Release date:2024-05-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Clr-11 from Rattus norvegicus
To Be Published
8TM0
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Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class I polypeptide-related sequence A, ...
Authors:Rupert, P.B, Strong, R.
Deposit date:2023-07-27
Release date:2024-04-17
Method:X-RAY DIFFRACTION (3.83 Å)
Cite:Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys.
Heliyon, 10, 2024
8TM2
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Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:Rupert, P.B, Strong, R.
Deposit date:2023-07-27
Release date:2024-04-17
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys.
Heliyon, 10, 2024
9B4H
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BU of 9b4h by Molmil
Chlamydomonas reinhardtii mastigoneme filament
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C-type lectin domain-containing protein, Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein, ...
Authors:Dai, J, Ma, M, Zhang, R, Brown, A.
Deposit date:2024-03-20
Release date:2024-04-10
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Mastigoneme structure reveals insights into the O-linked glycosylation code of native hydroxyproline-rich helices.
Cell, 2024
8JAH
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BU of 8jah by Molmil
Crystal structure of human CLEC12A C-type lectin domain
Descriptor: C-type lectin domain family 12 member A, POTASSIUM ION, SULFATE ION
Authors:Lei, Q, Tang, H, Dong, X.
Deposit date:2023-05-06
Release date:2024-03-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Mechanistic insights into the C-type lectin receptor CLEC12A-mediated immune recognition of monosodium urate crystal.
J.Biol.Chem., 300, 2024
8W9J
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BU of 8w9j by Molmil
Crystal structure of human CLEC12A ectodomain complexed with 50C1 Fab
Descriptor: Anti-human CLEC12A antibody 50C1 heavy chain, Anti-human CLEC12A antibody 50C1 light chain, C-type lectin domain family 12 member A
Authors:Mori, S, Nagae, M, Yamasaki, S.
Deposit date:2023-09-05
Release date:2024-03-06
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of the complex of CLEC12A and an antibody that interferes with binding of diverse ligands.
Int.Immunol., 36, 2024
8W8T
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BU of 8w8t by Molmil
Crystal structure of human CLEC12A CRD
Descriptor: C-type lectin domain family 12 member A, SULFATE ION
Authors:Mori, S, Nagae, M, Yamasaki, S.
Deposit date:2023-09-04
Release date:2024-03-06
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the complex of CLEC12A and an antibody that interferes with binding of diverse ligands.
Int.Immunol., 36, 2024
8K8H
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Crystal structure of the CysR-CTLD3 fragment of human DEC205
Descriptor: Lymphocyte antigen 75
Authors:Qian, Y, Kong, D, Yu, B, He, Y.
Deposit date:2023-07-29
Release date:2024-02-28
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Interaction of human dendritic cell receptor DEC205/CD205 with keratins.
J.Biol.Chem., 300, 2024
8UMO
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BU of 8umo by Molmil
Murine CD94-NKG2A receptor in complex with Qa-1b presenting AMAPRTLLL
Descriptor: BROMIDE ION, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ...
Authors:MacLachlan, B.J, Rossjohn, J, Vivian, J.P.
Deposit date:2023-10-18
Release date:2024-01-17
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the murine CD94-NKG2A receptor in complex with Qa-1 b presenting an MHC-I leader peptide.
Febs J., 291, 2024
8IVD
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BU of 8ivd by Molmil
COMPLEX STRUCTURE OF CD93-IGFBP7
Descriptor: Insulin-like growth factor-binding protein 7,Complement component C1q receptor
Authors:Xu, Y.M, Song, G.J.
Deposit date:2023-03-27
Release date:2024-01-17
Last modified:2024-08-14
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Structural insight into CD93 recognition by IGFBP7.
Structure, 32, 2024
8HBC
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Crystal structure of the CysR-CTLD3 fragment of human DEC205
Descriptor: Lymphocyte antigen 75
Authors:Kong, D, Yu, B, Hu, Z, Cheng, C, Cao, L, He, Y.
Deposit date:2022-10-28
Release date:2023-11-01
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Interaction of human dendritic cell receptor DEC205/CD205 with keratins.
J.Biol.Chem., 300, 2024
8SE6
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BU of 8se6 by Molmil
NKG2D complexed with inhibitor 36
Descriptor: N-[(1S)-2-(dimethylamino)-2-oxo-1-{3-[3-(2,2,2-trifluoroethyl)azetidin-1-yl]phenyl}ethyl]-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, NKG2-D type II integral membrane protein, TETRAETHYLENE GLYCOL, ...
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2023-04-08
Release date:2023-10-11
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D).
Bioorg.Med.Chem.Lett., 96, 2023
8SE5
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NKG2D complexed with inhibitor 14
Descriptor: DI(HYDROXYETHYL)ETHER, N-{(1S)-2-[(1R,5S,6S)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, NKG2-D type II integral membrane protein, ...
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2023-04-08
Release date:2023-10-11
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D).
Bioorg.Med.Chem.Lett., 96, 2023
8H4V
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BU of 8h4v by Molmil
Mincle CRD complex with PGL trisaccharide
Descriptor: (2~{R},3~{R},4~{S},5~{S},6~{R})-6-(methoxymethyl)oxane-2,3,4,5-tetrol-(1-4)-6-deoxy-2,3-di-O-methyl-alpha-L-mannopyranose-(1-2)-3-O-methyl-alpha-L-rhamnopyranose, C-type lectin domain family 4 member E, CALCIUM ION
Authors:Ishizuka, S, Nagae, M, Yamasaki, S.
Deposit date:2022-10-11
Release date:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand.
Acs Cent.Sci., 9, 2023
8HB5
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Crystal structure of Mincle in complex with HD-275
Descriptor: (2~{R},3~{R},4~{S},5~{S},6~{R})-6-(methoxymethyl)oxane-2,3,4,5-tetrol, C-type lectin domain family 4 member E, CALCIUM ION
Authors:Ishizuka, S, Nagae, M, Yamasaki, S.
Deposit date:2022-10-27
Release date:2023-08-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand.
Acs Cent.Sci., 9, 2023
7QAJ
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BU of 7qaj by Molmil
ZK002 with Anti-angiogenic and Anti-inflamamtory Properties
Descriptor: SULFATE ION, Snaclec clone 2100755 alpha, Snaclec clone 2100755 beta
Authors:Wong, W.Y, Chan, B.D, Muk Lan Lee, M, Dai, X, Tsim, K.W.K, Hsiao, W.L.W, Li, M, Li, X.Y, Tai, W.C.S.
Deposit date:2021-11-17
Release date:2023-06-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Isolation and characterization of ZK002, a novel dual function snake venom protein from Deinagkistrodon acutus with anti-angiogenic and anti-inflammatory properties.
Front Pharmacol, 14, 2023
8EA8
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NKG2D complexed with inhibitor 4a
Descriptor: DI(HYDROXYETHYL)ETHER, N-{(1S)-2-(dimethylamino)-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, NKG2-D type II integral membrane protein, ...
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2022-08-28
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EA7
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NKG2D complexed with inhibitor 3g
Descriptor: (4M)-N-{(1S)-2-(dimethylamino)-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4-(1-methyl-1H-pyrazol-5-yl)-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, DI(HYDROXYETHYL)ETHER, NKG2-D type II integral membrane protein
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2022-08-28
Release date:2023-05-03
Last modified:2023-05-10
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EA5
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NKG2D complexed with inhibitor 1a
Descriptor: (3S,5aS,8aR)-3-benzyl-6-[(3,5-dichlorophenyl)methyl]-1,4-dimethyloctahydropyrrolo[3,2-e][1,4]diazepine-2,5-dione, NKG2-D type II integral membrane protein, TRIETHYLENE GLYCOL
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2022-08-28
Release date:2023-05-03
Last modified:2023-05-10
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EA9
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NKG2D complexed with inhibitor 4d
Descriptor: DI(HYDROXYETHYL)ETHER, N-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-(dimethylamino)-2-oxoethyl]-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, NKG2-D type II integral membrane protein, ...
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2022-08-28
Release date:2023-05-03
Last modified:2023-05-10
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EAB
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NKG2D complexed with inhibitor 4f
Descriptor: DI(HYDROXYETHYL)ETHER, N-[(1S)-2-oxo-1-[3-(trifluoromethyl)phenyl]-2-({4-[4-(trifluoromethyl)phenyl]pyridin-3-yl}amino)ethyl]-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, NKG2-D type II integral membrane protein
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2022-08-28
Release date:2023-05-03
Last modified:2023-05-10
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EAA
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NKG2D complexed with inhibitor 4e
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, N-{(1S)-2-(dimethylamino)-1-[3-methyl-5-(trifluoromethyl)phenyl]-2-oxoethyl}-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, ...
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2022-08-28
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EA6
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NKG2D complexed with inhibitor 3e
Descriptor: N-{(1S)-2-(dimethylamino)-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, NKG2-D type II integral membrane protein
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2022-08-28
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023

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PDB entries from 2024-09-18

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