8HB5

Crystal structure of Mincle in complex with HD-275

Summary for 8HB5

• Entry DOI: 10.2210/pdb8hb5/pdb
• Descriptor: C-type lectin domain family 4 member E, CALCIUM ION, (2~{R},3~{R},4~{S},5~{S},6~{R})-6-(methoxymethyl)oxane-2,3,4,5-tetrol, ... (4 entities in total)
• Functional Keywords: innate immunity, c-type lectin receptors, mycobacterium leprae, immune system
• Biological source: Bos taurus (cattle)
• Total number of polymer chains: 1
• Total formula weight: 17757.94

Authors

Ishizuka, S.,Nagae, M.,Yamasaki, S. (deposition date: 2022-10-27, release date: 2023-08-09)

• Primary citation: Ishizuka, S.,van Dijk, J.H.M.,Kawakita, T.,Miyamoto, Y.,Maeda, Y.,Goto, M.,Le Calvez, G.,Groot, L.M.,Witte, M.D.,Minnaard, A.J.,van der Marel, G.A.,Ato, M.,Nagae, M.,Codee, J.D.C.,Yamasaki, S.; PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand.; Acs Cent.Sci., 9:1388-1399, 2023; PubMed: 37521780; DOI: 10.1021/acscentsci.3c00040

Experimental method

X-RAY DIFFRACTION (2.6 Å)