8EAA

NKG2D complexed with inhibitor 4e

Summary for 8EAA

• Entry DOI: 10.2210/pdb8eaa/pdb
• Descriptor: NKG2-D type II integral membrane protein, N-{(1S)-2-(dimethylamino)-1-[3-methyl-5-(trifluoromethyl)phenyl]-2-oxoethyl}-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• Functional Keywords: nkg2d, immune system, immunosuppressant, immunosuppressant-inhibitor complex, immunosuppressant/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 30575.44

Authors

Thompson, A.A.,Grant, J.C.,Karpowich, N.K.,Sharma, S. (deposition date: 2022-08-28, release date: 2023-05-03, Last modification date: 2023-10-25)

• Primary citation: Thompson, A.A.,Harbut, M.B.,Kung, P.P.,Karpowich, N.K.,Branson, J.D.,Grant, J.C.,Hagan, D.,Pascual, H.A.,Bai, G.,Zavareh, R.B.,Coate, H.R.,Collins, B.C.,Cote, M.,Gelin, C.F.,Damm-Ganamet, K.L.,Gholami, H.,Huff, A.R.,Limon, L.,Lumb, K.J.,Mak, P.A.,Nakafuku, K.M.,Price, E.V.,Shih, A.Y.,Tootoonchi, M.,Vellore, N.A.,Wang, J.,Wei, N.,Ziff, J.,Berger, S.B.,Edwards, J.P.,Gardet, A.,Sun, S.,Towne, J.E.,Venable, J.D.,Shi, Z.,Venkatesan, H.,Rives, M.L.,Sharma, S.,Shireman, B.T.,Allen, S.J.; Identification of small-molecule protein-protein interaction inhibitors for NKG2D.; Proc.Natl.Acad.Sci.USA, 120:e2216342120-e2216342120, 2023; PubMed: 37098070; DOI: 10.1073/pnas.2216342120

Experimental method

X-RAY DIFFRACTION (1.57 Å)