8SZ2
| Stx2A1 bound to P8 stalk peptide | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, NONAETHYLENE GLYCOL, ... | Authors: | rudolph, M.J, Li, X.P. | Deposit date: | 2023-05-26 | Release date: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structure of Shiga toxin 2 A1 subunit with peptides that bind at the ribosome binding site and inhibit activity To Be Published
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5E1H
| Ricin toxin in complex with neutralizing single chain monoclonal antibodies (VHHs) | Descriptor: | CHLORIDE ION, F8(JOB10) VHH antibody, Ricin | Authors: | Rudolph, M.J, Vance, D, Shoemaker, C, Mantis, N. | Deposit date: | 2015-09-29 | Release date: | 2016-08-03 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.032 Å) | Cite: | Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit. Proteins, 84, 2016
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1SZ6
| MISTLETOE LECTIN I FROM VISCUM ALBUM. CRYSTAL STRUCTURE AT 2.05 A RESOLUTION | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, AZIDE ION, BETA-GALACTOSIDE SPECIFIC LECTIN I B CHAIN, ... | Authors: | Gabdoulkhakov, A.G, Guhlistova, N.E, Lyashenko, A.V, Krauspenhaar, R, Stoeva, S, Voelter, W, Nikonov, S.V, Betzel, C, Mikhailov, A.M. | Deposit date: | 2004-04-04 | Release date: | 2004-10-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal Structure of Viscum album Mistletoe Lectin I in native state at 2.05 A resolution, comparison of structure active site conformation in ricin and in viscumin TO BE PUBLISHED
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3V2K
| Crystal structure of ribosome inactivating protein from momordica balsamina complexed with the product of RNA substrate adenosine triphosphate at 2.0 A resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENINE, GLYCEROL, ... | Authors: | Kushwaha, G.S, Pandey, N, Sinha, M, Bhushan, A, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2011-12-12 | Release date: | 2012-01-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Crystal structures of a type-1 ribosome inactivating protein from Momordica balsamina in the bound and unbound states. Biochim.Biophys.Acta, 1824, 2012
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3MK9
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2R3D
| Ricin A-chain (recombinant) complex with Acetamide | Descriptor: | ACETAMIDE, Ricin A chain (EC 3.2.2.22), SULFATE ION | Authors: | Carra, J.H, McHugh, C.A, Mulligan, S, Machiesky, L.M, Soares, A.S, Millard, C.B. | Deposit date: | 2007-08-29 | Release date: | 2007-11-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Fragment-based identification of determinants of conformational and
spectroscopic change at the ricin active site BMC Struct.Biol., 7, 2007
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7KBK
| Ricin bound to VHH antibody V6E11 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Ricin, ... | Authors: | Rudolph, M.J. | Deposit date: | 2020-10-02 | Release date: | 2021-08-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.091 Å) | Cite: | Structural Analysis of Toxin-Neutralizing, Single-Domain Antibodies that Bridge Ricin's A-B Subunit Interface. J.Mol.Biol., 433, 2021
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1QCJ
| LOW TEMPERATURE COMPLEX OF POKEWEED ANTIVIRAL PROTEIN WITH PTEORIC ACID | Descriptor: | 2-AMINO-6-[(4-CARBOXY-PHENYLAMINO)-METHYL]-4-HYDROXY-PTERIDIN-1-IUM, POKEWEED ANTIVIRAL PROTEIN | Authors: | Kurinov, I.V, Myers, D.E, Irvin, J.D, Uckun, F.M. | Deposit date: | 1999-05-05 | Release date: | 1999-09-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | X-ray crystallographic analysis of the structural basis for the interactions of pokeweed antiviral protein with its active site inhibitor and ribosomal RNA substrate analogs. Protein Sci., 8, 1999
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1D6A
| STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN COMPLEXED WITH GUANINE | Descriptor: | GUANINE, POKEWEED ANTIVIRAL PROTEIN | Authors: | Kurinov, I.V, Rajamohan, F, Venkatachalam, T.K, Uckun, F.M. | Deposit date: | 1999-10-12 | Release date: | 1999-12-16 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | X-ray crystallographic analysis of the structural basis for the interaction of pokeweed antiviral protein with guanine residues of ribosomal RNA. Protein Sci., 8, 1999
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3NJS
| Crystal structure of the complex formed between typeI ribosome inactivating protein and lactose at 2.1A resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ribosome inactivating protein, ... | Authors: | Pandey, N, Kushwaha, G.S, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2010-06-18 | Release date: | 2010-07-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the complex formed between typeI ribosome inactivating protein and lactose at 2.1A resolution To be Published
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1BRY
| BRYODIN TYPE I RIP | Descriptor: | BRYODIN I | Authors: | Klei, H.E, Chang, C.Y. | Deposit date: | 1997-02-14 | Release date: | 1998-03-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular, biological, and preliminary structural analysis of recombinant bryodin 1, a ribosome-inactivating protein from the plant Bryonia dioica. Biochemistry, 36, 1997
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1ONK
| Mistletoe lectin I from viscum album | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, AZIDE ION, Beta-galactoside specific lectin I A chain, ... | Authors: | Gabdoulkhakov, A.G, Savoshkina, Y, Krauspenhaar, R, Stoeva, S, Konareva, N, Kornilov, V, Kornev, A.N, Voelter, W, Nikonov, S.V, Betzel, C, Mikhailov, A.M. | Deposit date: | 2003-02-28 | Release date: | 2004-02-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Mistletoe lectin I from viscum album To be Published
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1QCG
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6OCD
| Ricin A chain bound to VHH antibody V6D4 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, IMIDAZOLE, ... | Authors: | Rudolph, M.J. | Deposit date: | 2019-03-22 | Release date: | 2020-04-01 | Last modified: | 2020-10-14 | Method: | X-RAY DIFFRACTION (2.103 Å) | Cite: | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site. J.Mol.Biol., 432, 2020
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7TGI
| Single-domain VHH intrabodies neutralize ricin toxin | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Ricin chain A, ... | Authors: | Rudolph, M.J. | Deposit date: | 2022-01-07 | Release date: | 2022-10-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.104 Å) | Cite: | Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins. J.Biol.Chem., 298, 2022
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3N31
| Crystal Structure of the complex of type I ribosome inactivating protein with fucose at 2.1A resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ribosome inactivating protein, ... | Authors: | Kushwaha, G.S, Pandey, N, Perbandt, M, Betzel, C, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2010-05-19 | Release date: | 2010-06-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Crystal Structure of the complex of type I ribosome inactivating protein with fucose at 2.1A resolution To be Published
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6OCA
| Ricin A chain bound to VHH antibody V2G10 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Ricin A chain, ... | Authors: | Rudolph, M.J. | Deposit date: | 2019-03-22 | Release date: | 2020-04-01 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.113 Å) | Cite: | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site. J.Mol.Biol., 432, 2020
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3HIV
| Crystal structure of Saporin-L1 in complex with the trinucleotide inhibitor, a transition state analogue | Descriptor: | (2R,3R,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-2-({[(S)-({(3R,4R)-4-({[(S)-{[(2R,3R,4R,5R)-5-(2-amino-6-oxo-6,8-dihydro-9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-yl]oxy}(hydroxy)phosphoryl]oxy}methyl)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidin-3-yl}oxy)(hydroxy)phosphoryl]oxy}methyl)-4-methoxytetrahydrofuran-3-yl 3-hydroxypropyl hydrogen (S)-phosphate, Vacuolar saporin | Authors: | Ho, M, Sturm, M.B, Almo, S.C, Schramm, V.L. | Deposit date: | 2009-05-20 | Release date: | 2009-12-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc.Natl.Acad.Sci.USA, 106, 2009
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3SRP
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1ABR
| CRYSTAL STRUCTURE OF ABRIN-A | Descriptor: | ABRIN-A, beta-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-L-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, beta-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose | Authors: | Tahirov, T.H, Lu, T.-H, Liaw, Y.-C, Chu, S.-C, Lin, J.-Y. | Deposit date: | 1994-11-11 | Release date: | 1995-02-07 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Crystal structure of abrin-a at 2.14 A. J.Mol.Biol., 250, 1995
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1MOM
| CRYSTAL STRUCTURE OF MOMORDIN, A TYPE I RIBOSOME INACTIVATING PROTEIN FROM THE SEEDS OF MOMORDICA CHARANTIA | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MOMORDIN | Authors: | Husain, J, Tickle, I.J, Wood, S.P. | Deposit date: | 1994-03-04 | Release date: | 1994-05-31 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Crystal structure of momordin, a type I ribosome inactivating protein from the seeds of Momordica charantia. FEBS Lett., 342, 1994
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3HIQ
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4Q2V
| Crystal Structure of Ricin A chain complexed with Baicalin inhibitor | Descriptor: | 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, Ricin | Authors: | Deng, X, Li, X, Dong, J, Chen, Y. | Deposit date: | 2014-04-10 | Release date: | 2015-04-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.198 Å) | Cite: | Baicalin inhibits the lethality of ricin in mice by inducing protein oligomerization. J.Biol.Chem., 290, 2015
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1OBS
| STRUCTURE OF RICIN A CHAIN MUTANT | Descriptor: | RICIN A CHAIN | Authors: | Day, P.J, Ernst, S.R, Frankel, A.E, Monzingo, A.F, Pascal, J.M, Svinth, M, Robertus, J.D. | Deposit date: | 1996-06-25 | Release date: | 1997-06-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure and activity of an active site substitution of ricin A chain. Biochemistry, 35, 1996
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1AHA
| THE N-GLYCOSIDASE MECHANISM OF RIBOSOME-INACTIVATING PROTEINS IMPLIED BY CRYSTAL STRUCTURES OF ALPHA-MOMORCHARIN | Descriptor: | ADENINE, ALPHA-MOMORCHARIN | Authors: | Ren, J, Wang, Y, Dong, Y, Stuart, D.I. | Deposit date: | 1994-01-07 | Release date: | 1994-06-22 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The N-glycosidase mechanism of ribosome-inactivating proteins implied by crystal structures of alpha-momorcharin. Structure, 2, 1994
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