1MOM
CRYSTAL STRUCTURE OF MOMORDIN, A TYPE I RIBOSOME INACTIVATING PROTEIN FROM THE SEEDS OF MOMORDICA CHARANTIA
Summary for 1MOM
| Entry DOI | 10.2210/pdb1mom/pdb |
| Descriptor | MOMORDIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
| Functional Keywords | protein synthesis inhibitor(toxin) |
| Biological source | Momordica charantia (Bitter gourd, Balsam pear) |
| Total number of polymer chains | 1 |
| Total formula weight | 27834.71 |
| Authors | Husain, J.,Tickle, I.J.,Wood, S.P. (deposition date: 1994-03-04, release date: 1994-05-31, Last modification date: 2024-11-13) |
| Primary citation | Husain, J.,Tickle, I.J.,Wood, S.P. Crystal structure of momordin, a type I ribosome inactivating protein from the seeds of Momordica charantia. FEBS Lett., 342:154-158, 1994 Cited by PubMed Abstract: A type I ribosome-inactivating protein, extracted and purified from M. charantia seeds, was crystallised by vapour diffusion with polyethylene glycol at pH 7.2. X-ray data were collected to 2.1 A resolution and the structure solved by molecular replacement using the A-chain coordinates of ricin. The overall fold of the protein is similar to ricin but there are differences in secondary structure, on the surface and in the active site cleft. These differences are probably due in part to the evolution of the protein without a B-chain partner. The most extensive reorganisation occurs at the C-terminus whereas Tyr70 shows the greatest change in the active site cleft. PubMed: 8143869DOI: 10.1016/0014-5793(94)80491-5 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.16 Å) |
Structure validation
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