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1WYB
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BU of 1wyb by Molmil
Structure of 6-aminohexanoate-dimer hydrolase
Descriptor: 6-aminohexanoate-dimer hydrolase
Authors:Negoro, S, Ohki, T, Shibata, N, Mizuno, N, Wakitani, Y, Tsurukame, J, Matsumoto, K, Kawamoto, I, Takeo, M, Higuchi, Y.
Deposit date:2005-02-09
Release date:2005-09-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of 6-aminohexanoate-dimer hydrolase
To be Published
7SPN
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BU of 7spn by Molmil
Crystal structure of IS11, a thermophilic esterase
Descriptor: IS11
Authors:Stogios, P.J, Evdokimova, E, Khusnutdinova, A, Yakunin, A.F, Savchenko, A.
Deposit date:2021-11-02
Release date:2022-08-24
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Crystal structure of IS11, a thermophilic esterase
To Be Published
4IVK
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BU of 4ivk by Molmil
Crystal structure of a fammily VIII carboxylesterase in a complex with cephalothin.
Descriptor: CEPHALOTHIN GROUP, Carboxylesterases, SULFATE ION
Authors:An, Y.J, Kim, M.-K, Jeong, C.-S, Cha, S.-S.
Deposit date:2013-01-23
Release date:2013-06-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the beta-lactamase activity of EstU1, a family VIII carboxylesterase.
Proteins, 81, 2013
4IVI
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BU of 4ivi by Molmil
Crystal structure of a family VIII carboxylesterase.
Descriptor: Carboxylesterase, SULFATE ION
Authors:An, Y.J, Kim, M.-K, Jeong, C.-S, Cha, S.-S.
Deposit date:2013-01-23
Release date:2013-06-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the beta-lactamase activity of EstU1, a family VIII carboxylesterase.
Proteins, 81, 2013
4JXV
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BU of 4jxv by Molmil
X-ray crystal structure of AmpC beta-lactamase from E. coli in complex with a non-covalent inhibitor 3-{[2-(4-CARBOXYPHENYL)ETHYL]SULFAMOYL}THIOPHENE-2-CARBOXYLIC ACID (compound 5)
Descriptor: 3-{[2-(4-carboxyphenyl)ethyl]sulfamoyl}thiophene-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION
Authors:Powers, R.A, Hendershot, J.M.
Deposit date:2013-03-28
Release date:2014-04-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structure-based efforts to optimize a non-beta-lactam inhibitor of AmpC beta-lactamase.
Bioorg.Med.Chem., 22, 2014
1XX2
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BU of 1xx2 by Molmil
Refinement of P99 beta-lactamase from Enterobacter cloacae
Descriptor: Beta-lactamase
Authors:Knox, J.R, Sun, T.
Deposit date:2004-11-03
Release date:2004-11-23
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystallographic structure of a phosphonate derivative of the Enterobacter cloacae P99 cephalosporinase: mechanistic interpretation of a beta-lactamase transition-state analog.
Biochemistry, 33, 1994
5W14
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BU of 5w14 by Molmil
ADC-7 in complex with boronic acid transition state inhibitor S03043
Descriptor: 3-{1-[(2R)-2-borono-2-{[(thiophen-2-yl)acetyl]amino}ethyl]-1H-1,2,3-triazol-4-yl}benzoic acid, Beta-lactamase
Authors:Smolen, K.A, Powers, R.A, Wallar, B.J.
Deposit date:2017-06-01
Release date:2017-11-29
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Inhibition of Acinetobacter-Derived Cephalosporinase: Exploring the Carboxylate Recognition Site Using Novel beta-Lactamase Inhibitors.
ACS Infect Dis, 4, 2018
7U1B
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BU of 7u1b by Molmil
Crystal structure of EstG in complex with tantalum cluster
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BICINE, Beta-lactamase domain-containing protein, ...
Authors:Chen, Z, Gabelli, S.B.
Deposit date:2022-02-20
Release date:2023-01-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:EstG is a novel esterase required for cell envelope integrity in Caulobacter.
Curr.Biol., 33, 2023
7U1C
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BU of 7u1c by Molmil
Structure of EstG crystalized with SO4 and Tris
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-lactamase domain-containing protein, SODIUM ION, ...
Authors:Gabelli, S.B, Chen, Z.
Deposit date:2022-02-20
Release date:2023-01-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:EstG is a novel esterase required for cell envelope integrity in Caulobacter.
Curr.Biol., 33, 2023
7TI1
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BU of 7ti1 by Molmil
Structure of AmpC bound to RPX-7063 at 2.0A
Descriptor: 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ...
Authors:Clifton, M.C, Abendroth, J, Edwards, T.E, Hecker, S.J.
Deposit date:2022-01-12
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Broad-spectrum cyclic boronate beta-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability.
Bioorg.Med.Chem., 62, 2022
4JXS
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BU of 4jxs by Molmil
X-ray crystal structure of AmpC beta-lactamase from E. coli in complex with a non-covalent inhibitor 3-[(4-CARBOXYBENZYL)SULFAMOYL]THIOPHENE-2-CARBOXYLIC ACID (compound 4)
Descriptor: 3-[(4-carboxybenzyl)sulfamoyl]thiophene-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION
Authors:Powers, R.A, Hendershot, J.M.
Deposit date:2013-03-28
Release date:2014-05-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-based efforts to optimize a non-beta-lactam inhibitor of AmpC beta-lactamase.
Bioorg.Med.Chem., 22, 2014
1W7F
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BU of 1w7f by Molmil
Crystal structure of the class A beta-lactamase BS3 inhibited with isocitrate
Descriptor: BETA-LACTAMASE, ISOCITRIC ACID
Authors:Petrella, S, Sauvage, E, Herman, R, Charlier, P.
Deposit date:2004-09-01
Release date:2006-05-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Class a Beta-Lactamase Bs3 Bs3 Inhibited with Isocitrate
To be Published
1MXO
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BU of 1mxo by Molmil
AmpC beta-lactamase in complex with an m.carboxyphenylglycylboronic acid bearing the cephalothin R1 side chain
Descriptor: (1R)-1-(2-THIENYLACETYLAMINO)-1-(3-CARBOXYPHENYL)METHYLBORONIC ACID, Beta-lactamase, PHOSPHATE ION
Authors:Morandi, F, Caselli, E, Morandi, S, Focia, P.J, Blazquez, J, Shoichet, B.K, Prati, F.
Deposit date:2002-10-02
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Nanomolar inhibitors of AmpC beta-lactamase.
J.Am.Chem.Soc., 125, 2003
1MY8
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BU of 1my8 by Molmil
AmpC beta-lactamase in complex with an M.carboxyphenylglycylboronic acid bearing the cephalothin R1 side chain
Descriptor: (1R)-1-(2-THIENYLACETYLAMINO)-1-PHENYLMETHYLBORONIC ACID, PHOSPHATE ION, beta-lactamase
Authors:Morandi, F, Caselli, E, Morandi, S, Focia, P.J, Blazquez, J, Shoichet, B.K, Prati, F.
Deposit date:2002-10-03
Release date:2003-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Nanomolar inhibitors of AmpC beta-lactamase.
J.Am.Chem.Soc., 125, 2003
7UL6
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BU of 7ul6 by Molmil
CryoEM structure of full-length dimeric ClbP
Descriptor: Beta-lactamase
Authors:Velilla, J.A, Walsh Jr, R.M, Gaudet, R.
Deposit date:2022-04-04
Release date:2022-09-28
Last modified:2023-02-15
Method:ELECTRON MICROSCOPY (3.73 Å)
Cite:Structural basis of colibactin activation by the ClbP peptidase.
Nat.Chem.Biol., 19, 2023
1MPL
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BU of 1mpl by Molmil
CRYSTAL STRUCTURE OF PHOSPHONATE-INHIBITED D-ALA-D-ALA PEPTIDASE REVEALS AN ANALOG OF A TETRAHEDRAL TRANSITION STATE
Descriptor: D-alanyl-D-alanine carboxypeptidase, GLYCEROL, GLYCYL-L-A-AMINOPIMELYL-E-(D-2-AMINOETHYL)PHOSPHONATE
Authors:Silvaggi, N.R, Anderson, J.W, Brinsmade, S.R, Pratt, R.F, Kelly, J.A.
Deposit date:2002-09-12
Release date:2003-02-25
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:The Crystal Structure of Phosphonate-Inhibited d-Ala-d-Ala Peptidase Reveals an Analogue of a Tetrahedral Transition State.
Biochemistry, 42, 2003
4JXG
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BU of 4jxg by Molmil
Crystal Structure of AmpC beta-lactamase from E. coli in Complex with Oxacillin
Descriptor: (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid, Beta-lactamase, PHOSPHATE ION, ...
Authors:Wallar, B.J, Powers, R.A, Docter, B.E.
Deposit date:2013-03-28
Release date:2014-10-29
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Complexed structures of AmpC beta-lactamase
To be Published
5WAE
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BU of 5wae by Molmil
ADC-7 in complex with boronic acid transition state inhibitor CR167
Descriptor: 3-(5,7,7-trihydroxy-2,2,7-trioxo-6-oxa-2lambda~6~-thia-3-aza-7lambda~5~-phospha-5-boraheptan-1-yl)benzoic acid, Beta-lactamase
Authors:Powers, R.A, Wallar, B.J.
Deposit date:2017-06-26
Release date:2017-12-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.804 Å)
Cite:Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C beta-Lactamase.
ACS Infect Dis, 4, 2018
1ZKJ
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BU of 1zkj by Molmil
Structural Basis for the Extended Substrate Spectrum of CMY-10, a Plasmid-Encoded Class C beta-lactamase
Descriptor: ACETIC ACID, ZINC ION, extended-spectrum beta-lactamase
Authors:Cha, S.S, Jung, H.I, An, Y.J, Lee, S.H.
Deposit date:2005-05-03
Release date:2006-04-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural basis for the extended substrate spectrum of CMY-10, a plasmid-encoded class C beta-lactamase.
Mol.Microbiol., 60, 2006
7V21
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BU of 7v21 by Molmil
human Serine beta-lactamase-like protein LACTB truncation variant
Descriptor: Serine beta-lactamase-like protein LACTB, mitochondrial
Authors:Zhang, M.H, Yang, M.J.
Deposit date:2021-08-07
Release date:2022-02-16
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.
Structure, 30, 2022
7V1Y
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BU of 7v1y by Molmil
Serine beta-lactamase-like protein LACTB in complex with inhibitor
Descriptor: ALA-ALA-B3S, Serine beta-lactamase-like protein LACTB, mitochondrial
Authors:Zhang, M.H, Yang, M.J.
Deposit date:2021-08-07
Release date:2022-02-16
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.
Structure, 30, 2022
7V1Z
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BU of 7v1z by Molmil
human Serine beta-lactamase-like protein LACTB
Descriptor: Serine beta-lactamase-like protein LACTB, mitochondrial
Authors:Zhang, M.H, Yang, M.J.
Deposit date:2021-08-07
Release date:2022-02-16
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.
Structure, 30, 2022
1PI5
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BU of 1pi5 by Molmil
Structure of N289A mutant of AmpC in complex with SM2, carboxyphenylglycylboronic acid bearing the cephalothin R1 side chain
Descriptor: (1R)-1-(2-THIENYLACETYLAMINO)-1-(3-CARBOXYPHENYL)METHYLBORONIC ACID, Beta-lactamase, PHOSPHATE ION, ...
Authors:Roth, T.A, Minasov, G, Focia, P.J, Shoichet, B.K.
Deposit date:2003-05-29
Release date:2004-02-24
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Thermodynamic cycle analysis and inhibitor design against beta-lactamase.
Biochemistry, 42, 2003
1ZC2
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BU of 1zc2 by Molmil
Crystal Structure of plasmid-encoded class C beta-lactamase CMY-2 complexed with citrate molecule
Descriptor: CITRIC ACID, beta-lactamase class C
Authors:Bauvois, C, Jacquamet, L, Fieulaine, S, Frere, J.-M, Galleni, M, Ferrer, J.-L.
Deposit date:2005-04-10
Release date:2006-04-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystallographic structure of plasmid-encoded CMY-2 beta-lactamase revealed citrate molecule in the active site.
To be Published
1ONH
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BU of 1onh by Molmil
GC1 beta-lactamase with a penem inhibitor
Descriptor: 7-(5,6-DIHYDRO-8H-IMIDAZO[2,1-C][1,4]OXAZIN-2-YL)-6-FORMYL-2,7-DIHYDRO- [1,4]THIAZEPINE-3-CARBOXYLIC ACID, GLYCEROL, class C beta-lactamase
Authors:Nukaga, M, Nukaga, K, Knox, J.R.
Deposit date:2003-02-27
Release date:2003-12-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Inhibition of Class A and Class C Beta-Lactamases by Penems: Crystallographic Structures of a Novel 1,4-Thiazepine Intermediate
Biochemistry, 42, 2003

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PDB entries from 2024-09-18

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